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Volume 87, Issue 7

April 1 1996

In this Issue

ARTICLES
REVIEW
PHOTOGRAPHS
LETTER

Table of Contents

ARTICLES

B-chronic lymphocytic leukemia: a malignancy of anti-self B cells

F Caligaris-Cappio

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

E Mrozek,P Anderson,MA Caligiuri

Extracellular truncations of h beta c, the common signaling subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5, lead to ligand-independent activation

RJ D'Andrea,SC Barry,PA Moretti,K Jones,S Ellis,MA Vadas,GJ Goodall

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

PD Aplan,DS Chervinsky,M Stanulla,WC Burhans

P2X1 receptor activation in HL60 cells

G Buell,AD Michel,C Lewis,G Collo,PP Humphrey,A Surprenant

Functional inactivation in mice of the gene for the interleukin-3 (IL- 3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells

NA Nicola,L Robb,D Metcalf,D Cary,CC Drinkwater,CG Begley

Recombinant human erythropoietin in transfusion-dependent anemic patients with multiple myeloma and non-Hodgkin's lymphoma--a randomized multicenter study. The European Study Group of Erythropoietin (Epoetin Beta) Treatment in Multiple Myeloma and Non-Hodgkin's Lymphoma

A Osterborg,MA Boogaerts,R Cimino,U Essers,J Holowiecki,G Juliusson,G Jager,A Najman,D Peest

Estrogen modulates the recruitment of myelopoietic cell progenitors in rat through a stromal cell-independent mechanism involving apoptosis

NK Shevde,JW Pike

1,25-dihydroxyvitamin D3 differentiates normal neutrophilic promyelocytes to monocytes/macrophages in vitro

K Nakamura,T Takahashi,Y Sasaki,R Tsuyuoka,Y Okuno,M Kurino,K Ohmori,S Iho,K Nakao

Fine-structure epitope mapping of antierythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin structure

S Elliott,T Lorenzini,D Chang,J Barzilay,E Delorme,J Giffin,L Hesterberg

Isolation and characterization of conformation sensitive antierythropoietin monoclonal antibodies: effect of disulfide bonds and carbohydrate on recombinant human erythropoietin structure

S Elliott,D Chang,E Delorme,C Dunn,J Egrie,J Giffin,T Lorenzini,C Talbot,L Hesterberg

Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo model for genetically transferred chemoprotection

P Schwarzenberger,S Spence,N Lohrey,T Kmiecik,DL Longo,WJ Murphy,FW Ruscetti,JR Keller

Potentiation of granulocyte colony-stimulating factor-induced mobilization of circulating progenitor cells by seven-day pretreatment with interleukin-3

K Geissler,C Peschel,D Niederwieser,H Strobl,J Goldschmitt,L Ohler,P Bettelheim,P Kahls,C Huber,K Lechner,P Hocker,K Kolbe

Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro

CD Helgason,G Sauvageau,HJ Lawrence,C Largman,RK Humphries

The Ly-6E.1 (Sca-1) gene requires a 3' chromatin-dependent region for high-level gamma-interferon-induced hematopoietic cell expression

A Sinclair,B Daly,E Dzierzak

Effects of recombinant human megakaryocyte growth and development factor on platelet activation

G Montrucchio,MF Brizzi,G Calosso,S Marengo,L Pegoraro,G Camussi

Type I factor XIII deficiency is caused by a genetic defect of its b subunit: insertion of triplet AAC in exon III leads to premature termination in the second Sushi domain

T Izumi,T Hashiguchi,G Castaman,A Tosetto,F Rodeghiero,A Girolami,A Ichinose

Evidence for a novel binding protein to urokinase-type plasminogen activator in platelet membranes

Y Jiang,R Pannell,JN Liu,V Gurewich

Platelet glycoprotein (Gp) IX associates with GpIb alpha in the platelet membrane GpIb complex

G Wu,FJ Meloni,SS Shapiro

Analysis of Arg834Gln and Val902Glu type 2A von Willebrand disease mutations: studies with recombinant von Willebrand factor and correlation with patient characteristics

T Englender,A Lattuada,PM Mannucci,JE Sadler,A Inbal

Evidence for oligoclonal diversification of the VH6-containing immunoglobulin repertoire during reconstitution after bone marrow transplantation

I Nasman,I Lundkvist

Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14

RR Schumann,D Pfeil,N Lamping,C Kirschning,G Scherzinger,P Schlag,L Karawajew,F Herrmann

Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with granulocyte-macrophage colony-stimulating factor

GM Walsh,ML Williamson,FA Symon,GB Willars,AJ Wardlaw

Fas-mediated apoptosis in cultured human eosinophils

A Druilhe,Z Cai,S Haile,S Chouaib,M Pretolani

Phosphatase 2A participates in interferon-gamma's induced upregulation of C1 inhibitor mRNA expression

GD Heda,KJ Kehoe,F Mahdi,AH Schmaier

ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival

H Schwarz,FJ Blanco,J von Kempis,J Valbracht,M Lotz

VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4- 34) gene

MB Rettig,RA Vescio,J Cao,CH Wu,JC Lee,E Han,M DerDanielian,R Newman,C Hong,AK Lichtenstein,JR Berenson

Suppression of B-cell proliferation to lipopolysaccharide is mediated through induction of the nitric oxide pathway by tumor necrosis factor- alpha in mice with acute graft-versus-host disease

G Falzarano,W Krenger,KM Snyder,J Jr Delmonte,M Karandikar,JL Ferrara

Expression of granulocyte colony-stimulating factor and granulocyte colony-stimulating factor receptor genes in partially overlapping monoclonal B-cell populations from chronic lymphocytic leukemia patients

A Corcione,MV Corrias,S Daniele,S Zupo,M Spriano,V Pistoia

Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age

FG Behm,SC Raimondi,JL Frestedt,Q Liu,WM Crist,JR Downing,GK Rivera,JH Kersey,CH Pui

Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis

T Yamagami,H Sugiyama,K Inoue,H Ogawa,T Tatekawa,M Hirata,T Kudoh,T Akiyama,A Murakami,T Maekawa

Activation of erythroid-specific promoters during anthracycline-induced differentiation of K562 cells

A Aries,C Trentesaux,S Ottolenghi,JC Jardillier,P Jeannesson,A Doubeikovski

The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia

S Raynaud,H Cave,M Baens,C Bastard,V Cacheux,J Grosgeorge,C Guidal-Giroux,C Guo,E Vilmer,P Marynen,B Grandchamp

Relation of autonomous and interleukin-2-responsive growth of leukemic cells to survival in adult T-cell leukemia

N Arima,S Hidaka,H Fujiwara,K Matsushita,H Ohtsubo,K Arimura,T Kukita,J Fukumori,H Tanaka

CD30 (Ki-1)-positive malignant lymphomas: clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin's disease

DA Filippa,M Ladanyi,N Wollner,DJ Straus,JP O'Brien,C Portlock,M Gangi,M Sun

Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease

H Herbst,HD Foss,J Samol,I Araujo,H Klotzbach,H Krause,A Agathanggelou,G Niedobitek,H Stein

Cure of disseminated xenografted human Hodgkin's tumors by bispecific monoclonal antibodies and human T cells: the role of human T-cell subsets in a preclinical model

C Renner,S Bauer,U Sahin,W Jung,R van Lier,G Jacobs,G Held,M Pfreundschuh

Irradiated B7-1 transduced primary acute myelogenous leukemia (AML) cells can be used as therapeutic vaccines in murine AML

K Dunussi-Joannopoulos,HJ Weinstein,PW Nickerson,TB Strom,SJ Burakoff,JM Croop,RJ Arceci

1 alpha,25-dihydroxyvitamin D3-induced upregulation of calcineurin during leukemic HL-60 cell differentiation

SB Omay,K Nakai,T Kuno,H Shiku,M Nishikawa

Generation of phenotypically aged phosphatidylserine-expressing erythrocytes by dilauroylphosphatidylcholine-induced vesiculation

C Diaz,J Morkowski,AJ Schroit

Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes

P Hermand,PY Le Pennec,P Rouger,JP Cartron,P Bailly

Expression of RHD and RHCE gene products using retroviral transduction of K562 cells establishes the molecular basis of Rh blood group antigens

JS Smythe,ND Avent,PA Judson,SF Parsons,PG Martin,DJ Anstee

Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme

CE Naylor,P Rowland,AK Basak,S Gover,PJ Mason,JM Bautista,TJ Vulliamy,L Luzzatto,MJ Adams

Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells

JD Phillips,DV Kinikini,Y Yu,B Guo,EA Leibold

A novel mutation found in the 3' domain of NADH-cytochrome B5 reductase in an African-American family with type I congenital methemoglobinemia

MM Jenkins,JT Prchal

Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities [see comments]

MQ Lacy,PJ Kurtin,A Tefferi

Investigation of the relative infectivity and pathogenicity of different hepatitis C virus genotypes in hemophiliacs

LM Jarvis,CA Ludlam,JA Ellender,L Nemes,SP Field,E Song,A Chuansumrit,FE Preston,P Simmonds

Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation

DC Molrine,EC Guinan,JH Antin,SK Parsons,HJ Weinstein,C Wheeler,C McGarigle,P Blanding,NR Phillips,K Kinsella,K Deans,A Ciamarra,A Goorin,S George,DM Ambrosino

Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation

K Kubo,K Yamanaka,H Kiyoi,H Fukutani,M Ito,R Hayakawa,R Ohno,T Naoe

Patterns of hematopoietic chimerism following bone marrow transplantation for childhood acute lymphoblastic leukemia from volunteer unrelated donors

K Molloy,N Goulden,M Lawler,J Cornish,A Oakhill,D Pamphilon,M Potter,C Steward,K Langlands,P Humphries,SR McCann

Molecular analysis of T-cell receptor repertoire in bone marrow transplant recipients: evidence for oligoclonal T-cell expansion in graft-versus-host disease lesions

X Liu,V Chesnokova,SJ Forman,DJ Diamond

Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow transplantation

JE Sanders,J Hawley,W Levy,T Gooley,CD Buckner,HJ Deeg,K Doney,R Storb,K Sullivan,R Witherspoon,FR Appelbaum

Active immunization of murine allogeneic bone marrow transplant donors with B-cell tumor-derived idiotype: a strategy for enhancing the specific antitumor effect of marrow grafts

LW Kwak,R Pennington,DL Longo

REVIEW

Defects in Wiskott-Aldrich syndrome blood cells

E Remold-O'Donnell,FS Rosen,DM Kenney

PHOTOGRAPHS

Photograph

A. M. Dvorak

LETTER

Desmopressin-induced thrombocytopenia in von Willebrand disease patients with the Arg611His mutation in the A1 domain of von Willebrand factor [letter; comment]

G Castaman,F Rodeghiero,J Eikenboom

Decreased stability of the O allele mRNA transcript of the ABO gene [letter]

DS O'Keefe,A Dobrovic

High-dose melphalan and autologous bone marrow transplantation for systemic AL amyloidosis with cardiac involvement [letter]

P Moreau,N Milpied,P de Faucal,T Petit,P Herbouiller,R Bataille,JL Harousseau

Apoptosis in bone marrow of myelodysplastic syndrome patients [letter; comment]

AD Bogdanovic,GM Jankovic,MD Colovic,DP Trpinac,VZ Bumbasirevic

Thrombopoiesis and thrombopoietin: the significance of "non-Tpo" cytokines [letter; comment]

KJ Turner,SJ Goldman,JA Kaye,SC Clark

Intron 22 of factor VIII gene--a hot spot for structural aberrations causing severe hemophilia A [letter]

W Schroder,M Wehnert,FH Herrmann

In vivo induction of HLA-DR on human neutrophils in patients treated with interferon-gamma [letter]

W Reinisch,W Tillinger,C Lichtenberger,A Gangl,M Willheim,O Scheiner,G Steger

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