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BLOOD COMMENTARIES

In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.

The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.

This study reveals that successful therapeutic targeting of the CD47-SIRPα axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcγR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.

The authors discovered the important role that lipid mediators (resolvin D4 in this study) play in both formation and resolution of clots in deep vein thrombosis.

PLENARY PAPER

In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.

REVIEW ARTICLE

This review discusses the pathogenesis and current treatment of HIV-related lymphomas.

CLINICAL TRIALS AND OBSERVATIONS

The authors report a phase 1 study of romidepsin combined with oral 5-azacytidine in patients with relapsed/refractory lymphomas, including complete remissions in 3 patients with angioimmunoblastic T-cell lymphoma.

IMMUNOBIOLOGY AND IMMUNOTHERAPY

The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.

LYMPHOID NEOPLASIA

This study reveals that successful therapeutic targeting of the CD47-SIRPα axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcγR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.

MYELOID NEOPLASIA

This report presents the intriguing observation that cases with germline DEAD-box helicase 41 (DDX41) mutations represent a unique entity among adult myeloid neoplasms.

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

This study unveils an unanticipated role of L-selectin downstream of integrin outside-in signaling in important neutrophil effector functions, including the clearance of bacteria in infected tissues.

THROMBOSIS AND HEMOSTASIS

The authors discovered the important role that lipid mediators (resolvin D4 in this study) play in both formation and resolution of clots in deep vein thrombosis.

VASCULAR BIOLOGY

BLOOD WORK

ERRATUM

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