Table of Contents
Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis
In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.
CLINICAL TRIALS AND OBSERVATIONS
Oral 5-azacytidine and romidepsin exhibit marked activity in patients with PTCL: a multicenter phase 1 study
Clinical Trials & Observations
The authors report a phase 1 study of romidepsin combined with oral 5-azacytidine in patients with relapsed/refractory lymphomas, including complete remissions in 3 patients with angioimmunoblastic T-cell lymphoma.
IMMUNOBIOLOGY AND IMMUNOTHERAPY
The investigators present their analysis of primary cells from patients with human T-cell leukemia virus 1–associated adult T-cell leukemia/lymphoma treated in a phase 2 clinical trial with nivolumab to elucidate mechanisms of hyperprogression that halted the trial after just 3 patients received a single treatment.
Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress
Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas
This study reveals that successful therapeutic targeting of the CD47-SIRPα axis in peripheral T-cell lymphoma is highly dependent on the Fc-FcγR interaction and is augmented by cotreatment with the anti-CCR4–targeted monoclonal antibody mogamulizumab.
This report presents the intriguing observation that cases with germline DEAD-box helicase 41 (DDX41) mutations represent a unique entity among adult myeloid neoplasms.
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling
This study unveils an unanticipated role of L-selectin downstream of integrin outside-in signaling in important neutrophil effector functions, including the clearance of bacteria in infected tissues.
THROMBOSIS AND HEMOSTASIS
The authors discovered the important role that lipid mediators (resolvin D4 in this study) play in both formation and resolution of clots in deep vein thrombosis.
Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice
Ex vivo confocal image of recruited neutrophils (green) in the lung tissue (red) after Klebsiella pneumoniae–induced pneumonia in Sell−/− mice. Neutrophil migration and effector functions are dependent on L-selectin shedding from the neutrophil surface. See the article by Cappenberg et al on page 1445.
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