This review article summarizes the clinical outcomes and genotoxicity issues of gene therapy for hemoglobinopathies based on lentiviral vectors carrying a β-globin–like gene or genome editing to correct the erythropoietic defect.
HEMATOPOIESIS AND STEM CELLS
Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs
The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.
The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.
Five-year follow-up of SWOG S0816: limitations and values of a PET-adapted approach with stage III/IV Hodgkin lymphoma
The investigators present results on the long-term value and limitations of early interim positron emission tomography (PET) scanning in advanced Hodgkin lymphoma.
The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre− mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page 1214.
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