In a Plenary Paper, Middleton and colleagues describe important transcriptional and translational changes in murine and human platelets during sepsis, elucidating the emerging role of platelets in the complications of systemic inflammatory illness.
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
This Special Report, this month’s CME article, details evidence-based guidelines for the selection of optimal unrelated donors and cord blood units for allogeneic hematopoietic cell transplantation.
CLINICAL TRIALS AND OBSERVATIONS
GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia
Clinical Trials & Observations
High frequency of inactivating tetraspanin CD37 mutations in diffuse large B-cell lymphoma at immune-privileged sites
Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia
Luceno-Araujo et al use assays of mutations associated with myeloid malignancy to propose an integrative prognostic score for acute promyelocytic leukemia (ISAPL) in patients treated with all-trans retinoic acid and anthracycline-based therapy. They demonstrate that the ISAPL is superior for predicting outcomes and identifying patients who may benefit from alternative therapies to maximize their chance of a cure.
Sud and colleagues interrogated the familial risk of hematological malignancy in association with over 150 000 patients. The majority of hematological malignancies showed increased familial relative risk, most prominently in association with B-cell malignancies.
THROMBOSIS AND HEMOSTASIS
Singh et al investigated the relationship among stasis, fibrinolysis, and venous thromboembolism (VTE), demonstrating a complex interaction by which venous stasis activates both thrombosis and fibrinolysis. Blocking the effects of α2-antiplasmin abolishes VTE, suggesting a potential novel approach to preventing thrombosis.
Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion
Weibel-Palade (WPB) bodies are endothelial cell organelles that store von Willebrand factor (VWF) and other proteins important for vascular hemostasis. Holthenrich and colleagues used an elegant proximity proteomics approach to compile a complete catalog of WPB-associated proteins and identify Munc13-2 as a novel factor mediating VWF secretion via WPB exocytosis.
LETTERS TO BLOOD
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
Confocal image of human umbilical vein endothelial cells expressing a Rab27a-APEX2 construct that localizes to Weibel-Palade bodies (WPBs). APEX2 activation leads to the biotinylation of proximal proteins that constitute the WPB-associated proteome. See the article by Holthenrich et al on page 979.
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