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A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML
A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation
Pericardial effusion in Hodgkin lymphoma: a report from the Children’s Oncology Group AHOD0031 protocol
Issue Archive
Table of Contents
BLOOD COMMENTARIES
PLENARY PAPER
MYELOID NEOPLASIA
PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells
Josephine D. Kahn,Peter G. Miller,Alexander J. Silver,Rob S. Sellar,Shruti Bhatt,Christopher Gibson,Marie McConkey,Dylan Adams,Brenton Mar,Philipp Mertins,Shaunt Fereshetian,Karsten Krug,Haoling Zhu,Anthony Letai,Steven A. Carr,John Doench,Siddhartha Jaiswal,Benjamin L. Ebert
PERSPECTIVE
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML
Clinical Trials & Observations
Amir T. Fathi,Harry P. Erba,Jeffrey E. Lancet,Eytan M. Stein,Farhad Ravandi,Stefan Faderl,Roland B. Walter,Anjali S. Advani,Daniel J. DeAngelo,Tibor J. Kovacsovics,Anand Jillella,Dale Bixby,Moshe Y. Levy,Megan M. O’Meara,Phoenix A. Ho,Jenna Voellinger,Anthony S. Stein
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination
Yasushi Akahori,Linan Wang,Motohiro Yoneyama,Naohiro Seo,Satoshi Okumura,Yoshihiro Miyahara,Yasunori Amaishi,Sachiko Okamoto,Junichi Mineno,Hiroaki Ikeda,Takehiro Maki,Hiroshi Fujiwara,Yoshiki Akatsuka,Takuma Kato,Hiroshi Shiku
LYMPHOID NEOPLASIA
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Tammy Linlin Song,Maarja-Liisa Nairismägi,Yurike Laurensia,Jing-Quan Lim,Jing Tan,Zhi-Mei Li,Wan-Lu Pang,Atish Kizhakeyil,Giovani-Claresta Wijaya,Da-Chuan Huang,Sanjanaa Nagarajan,Burton Kuan-Hui Chia,Daryl Cheah,Yan-Hui Liu,Fen Zhang,Hui-Lan Rao,Tiffany Tang,Esther Kam-Yin Wong,Jin-Xin Bei,Jabed Iqbal,Nicholas-Francis Grigoropoulos,Siok-Bian Ng,Wee-Joo Chng,Bin-Tean Teh,Soo-Yong Tan,Navin Kumar Verma,Hao Fan,Soon-Thye Lim,Choon-Kiat Ong
PLATELETS AND THROMBOPOIESIS
Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction
Nagaharu Tsukiji,Osamu Inoue,Mitsuru Morimoto,Norifumi Tatsumi,Hiroaki Nagatomo,Koji Ueta,Toshiaki Shirai,Tomoyuki Sasaki,Shimon Otake,Shogo Tamura,Toshiaki Tachibana,Masataka Okabe,Masanori Hirashima,Yukio Ozaki,Katsue Suzuki-Inoue
AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Sophie Lepropre,Shakeel Kautbally,Marie Octave,Audrey Ginion,Marie-Blanche Onselaer,Gregory R. Steinberg,Bruce E. Kemp,Alexandre Hego,Odile Wéra,Sanne Brouns,Frauke Swieringa,Martin Giera,Victor M. Darley-Usmar,Jérôme Ambroise,Bruno Guigas,Johan Heemskerk,Luc Bertrand,Cécile Oury,Christophe Beauloye,Sandrine Horman
THROMBOSIS AND HEMOSTASIS
A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation
Brief Report
Vincent Muczynski,Caterina Casari,François Moreau,Gabriel Aymé,Charlotte Kawecki,Paulette Legendre,Valerie Proulle,Olivier D. Christophe,Cécile V. Denis,Peter J. Lenting
TRANSFUSION MEDICINE
LETTERS TO BLOOD
Pericardial effusion in Hodgkin lymphoma: a report from the Children’s Oncology Group AHOD0031 protocol
Clinical Trials & Observations
A novel disease-causing synonymous exonic mutation in GATA2 affecting RNA splicing
Claudia Wehr,Katja Grotius,Silvia Casadei,Dorothee Bleckmann,Sebastian F. N. Bode,Björn C. Frye,Maximilian Seidl,Suleyman Gulsuner,Mary-Claire King,Mary-Beth Percival,Colin C. Pritchard,Tom Walsh,David Wu,Siobán Keel,Ulrich Salzer
BLOOD WORK
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Cover Image
Cover Image
Immunofluorescence staining of podoplanin (Pdpn; green) and lymphatic vessel endothelial hyaluronan receptor 1 (Lyve-1; magenta) with 4′,6-diamidino-2-phenylindole (DAPI; blue) in Tie2-Cre, Pdpnfl/fl fetal lung. Lymphatic endothelial cell–specific Pdpn deletion leads to lung developmental abnormalities and neonatal lethality. See the article by Tsukiji et al on page 1167.
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