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Issue Archive

Volume 130, Issue 24
December 14 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Hydroxyurea for SCA in Africa: no malaria harm
Clinical Trials & Observations
Isaac Odame
View Articletitled, Hydroxyurea for SCA in Africa: no malaria harm
INSIDE BLOOD COMMENTARY
SETD2: a complex role in blood malignancy
Jonathan D. Licht
View Articletitled, SETD2: a complex role in blood malignancy
INSIDE BLOOD COMMENTARY
Of pools, oceans, and the Dead Sea
Samir K. Ballas
View Articletitled, Of pools, oceans, and the Dead Sea
INSIDE BLOOD COMMENTARY
On PAR with aPC to target inflammasomes
Steven R. Lentz
View Articletitled, On PAR with aPC to target inflammasomes
INSIDE BLOOD COMMENTARY
Complement and coagulation: so close, yet so far
Christoph Q. Schmidt,Admar Verschoor
View Articletitled, Complement and coagulation: so close, yet so far
INSIDE BLOOD COMMENTARY
HSCT cures ADA2 deficiency
Klaus-Michael Debatin
View Articletitled, HSCT cures ADA2 deficiency

PLENARY PAPER

CLINICAL TRIALS AND OBSERVATIONS
Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia
Clinical Trials & Observations
Robert O. Opoka,Christopher M. Ndugwa,Teresa S. Latham,Adam Lane,Heather A. Hume,Phillip Kasirye,James S. Hodges,Russell E. Ware,Chandy C. John
View Articletitled, Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia

REVIEW ARTICLE

Chimeric antigen receptor T-cell therapies for multiple myeloma
Clinical Trials & Observations
Lekha Mikkilineni,James N. Kochenderfer
View Articletitled, Chimeric antigen receptor T-cell therapies for multiple myeloma

HOW I TREAT

How I treat heavy menstrual bleeding associated with anticoagulants
Clinical Trials & Observations
Kochawan Boonyawat,Sarah H. O’Brien,Shannon M. Bates
View Articletitled, How I treat heavy menstrual bleeding associated with anticoagulants

CLINICAL TRIALS AND OBSERVATIONS

Ixazomib significantly prolongs progression-free survival in high-risk relapsed/refractory myeloma patients
Clinical Trials & Observations
Hervé Avet-Loiseau,Nizar J. Bahlis,Wee-Joo Chng,Tamas Masszi,Luisa Viterbo,Ludek Pour,Peter Ganly,Antonio Palumbo,Michele Cavo,Christian Langer,Andrzej Pluta,Arnon Nagler,Shaji Kumar,Dina Ben-Yehuda,S. Vincent Rajkumar,Jesus San-Miguel,Deborah Berg,Jianchang Lin,Helgi van de Velde,Dixie-Lee Esseltine,Alessandra di Bacco,Philippe Moreau,Paul G. Richardson
View Articletitled, Ixazomib significantly prolongs progression-free survival in high-risk relapsed/refractory myeloma patients
Supplemental data

HEMATOPOIESIS AND STEM CELLS

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity
Wei-Kai Hua,Jing Qi,Qi Cai,Emily Carnahan,Maria Ayala Ramirez,Ling Li,Guido Marcucci,Ya-Huei Kuo
View Articletitled, HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity
Supplemental data

LYMPHOID NEOPLASIA

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
Brenton G. Mar,S. Haihua Chu,Josephine D. Kahn,Andrei V. Krivtsov,Richard Koche,Cecilia A. Castellano,Jacob L. Kotlier,Rebecca L. Zon,Marie E. McConkey,Jonathan Chabon,Ryan Chappell,Peter V. Grauman,James J. Hsieh,Scott A. Armstrong,Benjamin L. Ebert
View Articletitled, <em>SETD2</em> alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
Supplemental data

MYELOID NEOPLASIA

Gene expression and risk of leukemic transformation in myelodysplasia
Yusuke Shiozawa,Luca Malcovati,Anna Gallì,Andrea Pellagatti,Mohsen Karimi,Aiko Sato-Otsubo,Yusuke Sato,Hiromichi Suzuki,Tetsuichi Yoshizato,Kenichi Yoshida,Yuichi Shiraishi,Kenichi Chiba,Hideki Makishima,Jacqueline Boultwood,Eva Hellström-Lindberg,Satoru Miyano,Mario Cazzola,Seishi Ogawa
View Articletitled, Gene expression and risk of leukemic transformation in myelodysplasia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion
Marcus A. Carden,Meredith E. Fay,Xinran Lu,Robert G. Mannino,Yumiko Sakurai,Jordan C. Ciciliano,Caroline E. Hansen,Satheesh Chonat,Clinton H. Joiner,David K. Wood,Wilbur A. Lam
View Articletitled, Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion
Supplemental data

THROMBOSIS AND HEMOSTASIS

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition
Sumra Nazir,Ihsan Gadi,Moh’d Mohanad Al-Dabet,Ahmed Elwakiel,Shrey Kohli,Sanchita Ghosh,Jayakumar Manoharan,Satish Ranjan,Fabian Bock,Ruediger C. Braun-Dullaeus,Charles T. Esmon,Tobias B. Huber,Eric Camerer,Chris Dockendorff,John H. Griffin,Berend Isermann,Khurrum Shahzad
View Articletitled, Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition
Supplemental data
In vivo–generated thrombin and plasmin do not activate the complement system in baboons
Brief Report
Ravi S. Keshari,Robert Silasi,Cristina Lupu,Fletcher B. Taylor, Jr,Florea Lupu
View Articletitled, In vivo–generated thrombin and plasmin do not activate the complement system in baboons
Supplemental data

TRANSPLANTATION

Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2
Clinical Trials & Observations
Hasan Hashem,Ashish R. Kumar,Ingo Müller,Florian Babor,Robbert Bredius,Jignesh Dalal,Amy P. Hsu,Steven M. Holland,Dennis D. Hickstein,Stephen Jolles,Robert Krance,Ghadir Sasa,Mervi Taskinen,Minna Koskenvuo,Janna Saarela,Joris van Montfrans,Keith Wilson,Barbara Bosch,Leen Moens,Michael Hershfield,Isabelle Meyts,on behalf of the Deficiency of Adenosine Deaminase Type 2 Foundation
View Articletitled, Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2

BLOOD WORK

Circulating hypergranular neoplastic cells: not always leukemic promyelocytes
Concepción Prats-Martín,Rosario M. Morales-Camacho
View Articletitled, Circulating hypergranular neoplastic cells: not always leukemic promyelocytes
  • Cover Image

    Cover Image

    issue cover

    A 5-μm-thick left ventricle cross-cryosection obtained 24 hours after reperfusion and stained by triphenyltetrazolium chloride solution (TTC). The pale region that fails to stain (TTC-negative region) represents nonviable infarcted myocardium. Constitutively active Nlrp3A350V abolishes the protective effect of activated protein C in myocardial ischemia reperfusion injury. See the article by Nazir et al on page 2664.

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  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkBack Matter
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