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Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis
Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
BDR in newly diagnosed patients with WM: final analysis of a phase 2 study after a minimum follow-up of 6 years
Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia
Issue Archive
January 26 2017
In this Issue
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPERS
Red Cells, Iron, and Erythropoiesis
Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis
Brief Report
Philipp-Sebastian Koch,Victor Olsavszky,Friederike Ulbrich,Carsten Sticht,Alexandra Demory,Thomas Leibing,Thomas Henzler,Mathias Meyer,Johanna Zierow,Sven Schneider,Katja Breitkopf-Heinlein,Haristi Gaitantzi,Bradley Spencer-Dene,Bernd Arnold,Kay Klapproth,Kai Schledzewski,Sergij Goerdt,Cyrill Géraud
BLOOD SPOTLIGHT
Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis
Clinical Trials & Observations
REVIEW ARTICLE
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
Clinical Trials & Observations
Hartmut Döhner,Elihu Estey,David Grimwade,Sergio Amadori,Frederick R. Appelbaum,Thomas Büchner,Hervé Dombret,Benjamin L. Ebert,Pierre Fenaux,Richard A. Larson,Ross L. Levine,Francesco Lo-Coco,Tomoki Naoe,Dietger Niederwieser,Gert J. Ossenkoppele,Miguel Sanz,Jorge Sierra,Martin S. Tallman,Hwei-Fang Tien,Andrew H. Wei,Bob Löwenberg,Clara D. Bloomfield
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
BDR in newly diagnosed patients with WM: final analysis of a phase 2 study after a minimum follow-up of 6 years
Clinical Trials & Observations
Brief Report
Maria Gavriatopoulou,Ramón García-Sanz,Efstathios Kastritis,Pierre Morel,Marie-Christine Kyrtsonis,Eurydiki Michalis,Zafiris Kartasis,Xavier Leleu,Giovanni Palladini,Alessandra Tedeschi,Dimitra Gika,Giampaolo Merlini,Pieter Sonneveld,Meletios A. Dimopoulos
HEMATOPOIESIS AND STEM CELLS
The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling
Jin Li,Tamara Riedt,Steven Goossens,Carmen Carrillo García,Sabrina Szczepanski,Maria Brandes,Tim Pieters,Linne Dobrosch,Ines Gütgemann,Natalie Farla,Enrico Radaelli,Paco Hulpiau,Nikhil Mallela,Holger Fröhlich,Roberta La Starza,Caterina Matteucci,Tong Chen,Peter Brossart,Cristina Mecucci,Danny Huylebroeck,Jody J. Haigh,Viktor Janzen
LYMPHOID NEOPLASIA
Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma
Kilannin Krysiak,Felicia Gomez,Brian S. White,Matthew Matlock,Christopher A. Miller,Lee Trani,Catrina C. Fronick,Robert S. Fulton,Friederike Kreisel,Amanda F. Cashen,Kenneth R. Carson,Melissa M. Berrien-Elliott,Nancy L. Bartlett,Malachi Griffith,Obi L. Griffith,Todd A. Fehniger
MYELOID NEOPLASIA
Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes
Virginie Chesnais,Marie-Laure Arcangeli,Caroline Delette,Alice Rousseau,Hélène Guermouche,Carine Lefevre,Sabrina Bondu,M’boyba Diop,Meyling Cheok,Nicolas Chapuis,Laurence Legros,Sophie Raynaud,Lise Willems,Didier Bouscary,Evelyne Lauret,Olivier A. Bernard,Olivier Kosmider,Françoise Pflumio,Michaela Fontenay
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia
Brief Report
Suthesh Sivapalaratnam,Sarah K. Westbury,Jonathan C. Stephens,Daniel Greene,Kate Downes,Anne M. Kelly,Claire Lentaigne,William J. Astle,Eric G. Huizinga,Paquita Nurden,Sofia Papadia,Kathelijne Peerlinck,Christopher J. Penkett,David J. Perry,Catherine Roughley,Ilenia Simeoni,Kathleen Stirrups,Daniel P. Hart,R. Campbell Tait,Andrew D. Mumford,NIHR BioResource,Michael A. Laffan,Kathleen Freson,Willem H. Ouwehand,Shinji Kunishima,Ernest Turro
TRANSPLANTATION
Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation
Renato Cunha,Marco A. Zago,Sergio Querol,Fernanda Volt,Annalisa Ruggeri,Guillermo Sanz,Fabienne Pouthier,Gesine Kogler,José L. Vicario,Paola Bergamaschi,Riccardo Saccardi,Carmen H. Lamas,Cristina Díaz-de-Heredia,Gerard Michel,Henrique Bittencourt,Marli Tavella,Rodrigo A. Panepucci,Francisco Fernandes,Julia Pavan,Eliane Gluckman,Vanderson Rocha,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo,on behalf of Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo
LETTER TO BLOOD
BLOOD WORK
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Cover Image
Cover Image
Immunofluorescence microscopy of liver from Rosa26CAG-tdTomato Alb-Cre+ reporter mice demonstrates Cre-mediated recombination in hepatocytes (labeled red) but not Kupffer cells (labeled green with F4/80 antibody). See the article by Canali et al on page 405.
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