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Issue Archive

Volume 127, Issue 25
June 23 2016
Issue Cover

Table of Contents

BLOOD FLASHBACK

Conrad ME Jr, Crosby WH. Intestinal mucosal mechanisms controlling iron absorption. Blood. 1963;22(4):406-415.
View Articletitled, Conrad ME Jr, Crosby WH. Intestinal mucosal mechanisms controlling iron absorption. <em>Blood</em>. 1963;22(4):<span class="related-article">406-415</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
When the STATs are against you
Clinical Trials & Observations
Sophie Hambleton
View Articletitled, When the STATs are against you
INSIDE BLOOD COMMENTARY
To BH3 profile or not to BH3 profile
Matthew D. Blunt,Andrew J. Steele
View Articletitled, To BH3 profile or not to BH3 profile
INSIDE BLOOD COMMENTARY
In the beginning and at the end: calreticulin
William M. Nauseef
View Articletitled, In the beginning and at the end: calreticulin
INSIDE BLOOD COMMENTARY
Coagulation signaling to epithelia
Toni M. Antalis
View Articletitled, Coagulation signaling to epithelia

PERSPECTIVES

Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?
Robert Zeiser,Bruce R. Blazar
View Articletitled, Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?

BLOOD SPOTLIGHT

Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma
Mark Roschewski,Louis M. Staudt,Wyndham H. Wilson
View Articletitled, Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma

REVIEW ARTICLE

Acquired von Willebrand syndrome associated with left ventricular assist device
Clinical Trials & Observations
Angelo Nascimbene,Sriram Neelamegham,O. H. Frazier,Joel L. Moake,Jing-fei Dong
View Articletitled, Acquired von Willebrand syndrome associated with left ventricular assist device

HOW I TREAT

How I treat mycosis fungoides and Sézary syndrome
Clinical Trials & Observations
Sean Whittaker,Richard Hoppe,H. Miles Prince
View Articletitled, How I treat mycosis fungoides and Sézary syndrome

CLINICAL TRIALS AND OBSERVATIONS

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
Clinical Trials & Observations
Julie Toubiana,Satoshi Okada,Julia Hiller,Matias Oleastro,Macarena Lagos Gomez,Juan Carlos Aldave Becerra,Marie Ouachée-Chardin,Fanny Fouyssac,Katta Mohan Girisha,Amos Etzioni,Joris Van Montfrans,Yildiz Camcioglu,Leigh Ann Kerns,Bernd Belohradsky,Stéphane Blanche,Aziz Bousfiha,Carlos Rodriguez-Gallego,Isabelle Meyts,Kai Kisand,Janine Reichenbach,Ellen D. Renner,Sergio Rosenzweig,Bodo Grimbacher,Frank L. van de Veerdonk,Claudia Traidl-Hoffmann,Capucine Picard,Laszlo Marodi,Tomohiro Morio,Masao Kobayashi,Desa Lilic,Joshua D. Milner,Steven Holland,Jean-Laurent Casanova,Anne Puel,on behalf of the International STAT1 Gain-of-Function Study Group
View Articletitled, Heterozygous <em>STAT1</em> gain-of-function mutations underlie an unexpectedly broad clinical phenotype
Supplemental data
Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients
Clinical Trials & Observations
Bruno Paiva,Maria-Teresa Cedena,Noemi Puig,Paula Arana,Maria-Belen Vidriales,Lourdes Cordon,Juan Flores-Montero,Norma C. Gutierrez,María-Luisa Martín-Ramos,Joaquin Martinez-Lopez,Enrique M. Ocio,Miguel T. Hernandez,Ana-Isabel Teruel,Laura Rosiñol,María-Asunción Echeveste,Rafael Martinez,Mercedes Gironella,Albert Oriol,Carmen Cabrera,Jesus Martin,Joan Bargay,Cristina Encinas,Yolanda Gonzalez,Jacques J. M. Van Dongen,Alberto Orfao,Joan Bladé,Maria-Victoria Mateos,Juan José Lahuerta,Jesús F. San Miguel,on behalf of the Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas (GEM/PETHEMA) Cooperative Study Groups
View Articletitled, Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo
Brief Report
Larisa V. Kovtonyuk,Markus G. Manz,Hitoshi Takizawa
View Articletitled, Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo
Supplemental data

IMMUNOBIOLOGY

Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome
Xuan Zhang,Rongxin Dai,Wenyan Li,Hongyi Zhao,Yongjie Zhang,Lina Zhou,Hongqiang Du,Guangjin Luo,Junfeng Wu,Linlin Niu,Yunfei An,Zhiyong Zhang,Yuan Ding,Wenxia Song,Chaohong Liu,Xiaodong Zhao
View Articletitled, Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome
Supplemental data

LYMPHOID NEOPLASIA

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199
Kamil Bojarczuk,Binu K. Sasi,Stefania Gobessi,Idanna Innocenti,Gabriele Pozzato,Luca Laurenti,Dimitar G. Efremov
View Articletitled, BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199
Supplemental data
A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma
Aneta Schieferdecker,Anna Oberle,Benjamin Thiele,Fabian Hofmann,Markus Göthel,Sebastian Miethe,Michael Hust,Friederike Braig,Mareike Voigt,Ute-Marie von Pein,Friedrich Koch-Nolte,Friedrich Haag,Malik Alawi,Daniela Indenbirken,Adam Grundhoff,Carsten Bokemeyer,Ulrike Bacher,Nicolaus Kröger,Mascha Binder
View Articletitled, A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma
Supplemental data
The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism
Mary Ann Anderson,Jing Deng,John F. Seymour,Constantine Tam,Su Young Kim,Joshua Fein,Lijian Yu,Jennifer R. Brown,David Westerman,Eric G. Si,Ian J. Majewski,David Segal,Sari L. Heitner Enschede,David C. S. Huang,Matthew S. Davids,Anthony Letai,Andrew W. Roberts
View Articletitled, The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism
Supplemental data
APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment
Yu-Tzu Tai,Chirag Acharya,Gang An,Michele Moschetta,Mike Y. Zhong,Xiaoyan Feng,Michele Cea,Antonia Cagnetta,Kenneth Wen,Hans van Eenennaam,Andrea van Elsas,Lugui Qiu,Paul Richardson,Nikhil Munshi,Kenneth C. Anderson
View Articletitled, APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment
Supplemental data
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib
Guang Yang,Sara J. Buhrlage,Li Tan,Xia Liu,Jie Chen,Lian Xu,Nicholas Tsakmaklis,Jiaji G. Chen,Christopher J. Patterson,Jennifer R. Brown,Jorge J. Castillo,Wei Zhang,Xiaofeng Zhang,Shuai Liu,Philip Cohen,Zachary R. Hunter,Nathanael Gray,Steven P. Treon
View Articletitled, HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

MYELOID NEOPLASIA

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency
Alexandre P. A. Theocharides,Pontus Lundberg,Asvin K. K. Lakkaraju,Veronika Lysenko,Renier Myburgh,Adriano Aguzzi,Radek C. Skoda,Markus G. Manz
View Articletitled, Homozygous <em>calreticulin</em> mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency
Supplemental data

THROMBOSIS AND HEMOSTASIS

Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling
Sylvain M. Le Gall,Roman Szabo,Melody Lee,Daniel Kirchhofer,Charles S. Craik,Thomas H. Bugge,Eric Camerer
View Articletitled, Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling
Supplemental data

TRANSPLANTATION

Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice
Kazuhiro Mochizuki,Lijun Meng,Izumi Mochizuki,Qing Tong,Shan He,Yongnian Liu,Janaki Purushe,Henry Fung,M. Raza Zaidi,Yanyun Zhang,Ran Reshef,Bruce R. Blazar,Hideo Yagita,Shin Mineishi,Yi Zhang
View Articletitled, Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice
Supplemental data
The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Bernd Hartz,Rebecca Marsh,Kanchan Rao,Jan-Inge Henter,Michael Jordan,Lisa Filipovich,Peter Bader,Rita Beier,Birgit Burkhardt,Roland Meisel,Ansgar Schulz,Beate Winkler,Michael H. Albert,Johann Greil,Gülsün Karasu,Wilhelm Woessmann,Selim Corbacioglu,Bernd Gruhn,Wolfgang Holter,Jörn-Sven Kühl,Peter Lang,Markus G. Seidel,Paul Veys,Alexandra Löfstedt,Sandra Ammann,Stephan Ehl,Gritta Janka,Ingo Müller,Kai Lehmberg
View Articletitled, The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis
Supplemental data

BLOOD WORK

Anaplastic variant of plasma cell myeloma with Dutcher bodies
Hong Chang,Babita Kajal
View Articletitled, Anaplastic variant of plasma cell myeloma with Dutcher bodies
Discrete vacuoles in lymphocytes as a subtle clue to mantle cell lymphoma
David T. Lynch,Kathryn Foucar
View Articletitled, Discrete vacuoles in lymphocytes as a subtle clue to mantle cell lymphoma
  • Cover Image

    Cover Image

    issue cover

    Determination of myeloperoxidase (MPO) activity by immunocytochemistry on a peripheral blood smear of a patient with myelofibrosis and acquired MPO deficiency. Brown precipitates represent MPO-positive granules. The image shows an MPO-positive and an MPO-deficient neutrophil granulocyte. MPO-deficient neutrophil granulocytes carry a homozygous calreticulin mutation. See the article by Theocharides et al on page 3253.

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