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Issue Archive

Volume 124, Issue 14
October 2 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Platelet microparticles are not created equal
Jing-fei Dong
View Articletitled, Platelet microparticles are not created equal
INSIDE BLOOD COMMENTARY
A key to the quest?
Clinical Trials & Observations
Xavier Leleu
View Articletitled, A key to the quest?
INSIDE BLOOD COMMENTARY
PP2A inactivation by ROS accumulation
Shingo Nakahata,Kazuhiro Morishita
View Articletitled, PP2A inactivation by ROS accumulation
INSIDE BLOOD COMMENTARY
The SOX11-PDGFA axis in mantle cell lymphoma
Eric D. Hsi
View Articletitled, The SOX11-PDGFA axis in mantle cell lymphoma
INSIDE BLOOD COMMENTARY
Platelet 12-LOX scores a HIT
Alison H. Goodall
View Articletitled, Platelet 12-LOX scores a HIT
INSIDE BLOOD COMMENTARY
Less Jak2 makes more platelets
Radek C. Skoda
View Articletitled, Less <em>Jak2</em> makes more platelets
INSIDE BLOOD COMMENTARY
Exosome complex and erythropoiesis
Xiuli An
View Articletitled, Exosome complex and erythropoiesis
INSIDE BLOOD COMMENTARY
Warfarin pharmacogenetics: it matters if you’re black or white
Mia Wadelius
View Articletitled, Warfarin pharmacogenetics: it matters if you’re black or white

PLENARY PAPER

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
Luc H. Boudreau,Anne-Claire Duchez,Nathalie Cloutier,Denis Soulet,Nicolas Martin,James Bollinger,Alexandre Paré,Matthieu Rousseau,Gajendra S. Naika,Tania Lévesque,Cynthia Laflamme,Geneviève Marcoux,Gérard Lambeau,Richard W. Farndale,Marc Pouliot,Hind Hamzeh-Cognasse,Fabrice Cognasse,Olivier Garraud,Peter A. Nigrovic,Helga Guderley,Steve Lacroix,Louis Thibault,John W. Semple,Michael H. Gelb,Eric Boilard
View Articletitled, Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A<sub>2</sub> to promote inflammation
Supplemental data

BLOOD SPOTLIGHT

How does lenalidomide target the chronic lymphocytic leukemia microenvironment?
Arnon P. Kater,Sanne H. Tonino,Alexander Egle,Alan G. Ramsay
View Articletitled, How does lenalidomide target the chronic lymphocytic leukemia microenvironment?
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
Clinical Trials & Observations
Andrew Spencer,Sung-Soo Yoon,Simon J. Harrison,Shannon R. Morris,Deborah A. Smith,Richard A. Brigandi,Jennifer Gauvin,Rakesh Kumar,Joanna B. Opalinska,Christine Chen
View Articletitled, The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
Supplemental data
Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study
Clinical Trials & Observations
Guillaume Cartron,Sophie de Guibert,Marie-Sarah Dilhuydy,Franck Morschhauser,Veronique Leblond,Jehan Dupuis,Beatrice Mahe,Reda Bouabdallah,Guiyuan Lei,Michael Wenger,Elisabeth Wassner-Fritsch,Michael Hallek
View Articletitled, Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice
Kentson Lam,Alexander Muselman,Randal Du,Yuka Harada,Amanda G. Scholl,Ming Yan,Shinobu Matsuura,Stephanie Weng,Hironori Harada,Dong-Er Zhang
View Articletitled, <em>Hmga2</em> is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice
Supplemental data

IMMUNOBIOLOGY

Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions
Martin R. Goodier,Matthew J. White,Alansana Darboe,Carolyn M. Nielsen,Adriana Goncalves,Christian Bottomley,Sophie E. Moore,Eleanor M. Riley
View Articletitled, Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions
Supplemental data

LYMPHOID NEOPLASIA

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity
Ivan Cherh Chiet Low,Thomas Loh,Yiqing Huang,David M. Virshup,Shazib Pervaiz
View Articletitled, Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity
Supplemental data
SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
Jara Palomero,Maria Carmela Vegliante,Marta Leonor Rodríguez,Álvaro Eguileor,Giancarlo Castellano,Ester Planas-Rigol,Pedro Jares,Inmaculada Ribera-Cortada,Maria C. Cid,Elias Campo,Virginia Amador
View Articletitled, SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
Supplemental data
KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse
Brief Report
Florian Babor,Angela R. Manser,Johannes C. Fischer,Nadine Scherenschlich,Jürgen Enczmann,Olympe Chazara,Ashley Moffett,Arndt Borkhardt,Roland Meisel,Markus Uhrberg
View Articletitled, KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse
Supplemental data

MYELOID NEOPLASIA

STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation
Daniel J. Gough,Isabelle J. Marié,Camille Lobry,Iannis Aifantis,David E. Levy
View Articletitled, STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation
Supplemental data

PLATELETS AND THROMBOPOIESIS

CLEC-2 expression is maintained on activated platelets and on platelet microparticles
Eelo Gitz,Alice Y. Pollitt,Jerney J. Gitz-Francois,Osama Alshehri,Jun Mori,Samantha Montague,Gerard B. Nash,Michael R. Douglas,Elizabeth E. Gardiner,Robert K. Andrews,Christopher D. Buckley,Paul Harrison,Steve P. Watson
View Articletitled, CLEC-2 expression is maintained on activated platelets and on platelet microparticles
Supplemental data
Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
Jennifer Yeung,Benjamin E. Tourdot,Pilar Fernandez-Perez,Joanne Vesci,Jin Ren,Christopher J. Smyrniotis,Diane K. Luci,Ajit Jadhav,Anton Simeonov,David J. Maloney,Theodore R. Holman,Steven E. McKenzie,Michael Holinstat
View Articletitled, Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
Supplemental data
Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis
Brief Report
Sara C. Meyer,Matthew D. Keller,Brittany A. Woods,Lindsay M. LaFave,Lennart Bastian,Maria Kleppe,Neha Bhagwat,Sachie Marubayashi,Ross L. Levine
View Articletitled, Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

The exosome complex establishes a barricade to erythroid maturation
Skye C. McIver,Yoon-A Kang,Andrew W. DeVilbiss,Chelsea A. O’Driscoll,Jonathan N. Ouellette,Nathaniel J. Pope,Genis Camprecios,Chan-Jung Chang,David Yang,Eric E. Bouhassira,Saghi Ghaffari,Emery H. Bresnick
View Articletitled, The exosome complex establishes a barricade to erythroid maturation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans
Clinical Trials & Observations
Roxana Daneshjou,Eric R. Gamazon,Ben Burkley,Larisa H. Cavallari,Julie A. Johnson,Teri E. Klein,Nita Limdi,Sara Hillenmeyer,Bethany Percha,Konrad J. Karczewski,Taimour Langaee,Shitalben R. Patel,Carlos D. Bustamante,Russ B. Altman,Minoli A. Perera
View Articletitled, Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans
Supplemental data

TRANSPLANTATION

BFR (bendamustine, fludarabine, and rituximab) allogeneic conditioning for chronic lymphocytic leukemia/lymphoma: reduced myelosuppression and GVHD
Issa F. Khouri,Wei Wei,Martin Korbling,Francesco Turturro,Sairah Ahmed,Amin Alousi,Paolo Anderlini,Stefan Ciurea,Elias Jabbour,Betul Oran,Uday R. Popat,Gabriela Rondon,Roland L. Bassett, Jr,Alison Gulbis
View Articletitled, BFR (bendamustine, fludarabine, and rituximab) allogeneic conditioning for chronic lymphocytic leukemia/lymphoma: reduced myelosuppression and GVHD

BLOOD WORK

Metastatic lobular breast carcinoma mimicking multiple myeloma
Rouslan Kotchetkov,Erin Ellison
View Articletitled, Metastatic lobular breast carcinoma mimicking multiple myeloma
Parvovirus infection mimicking a myeloproliferative neoplasm in a toddler with sickle cell disease
Emily Y. Jen,Ronald Jackups, Jr
View Articletitled, Parvovirus infection mimicking a myeloproliferative neoplasm in a toddler with sickle cell disease
All Issues

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