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Targeted deletion of mouse Tmod3 leads to embryonic lethality with anemia due to defects in definitive erythropoiesis in the fetal liver. Native erythroblastic island formation was impaired in Tmod3^−/− fetal livers, with Tmod3 required in both erythroblasts and macrophages. Tmod3-mediated actin remodeling may be required for erythroblast-macrophage adhesion as well as coordination of cell cycle with differentiation, and F-actin assembly and remodeling during erythroblast enucleation. This image shows erythroblast-macrophage islands in wild-type fetal livers, which were stained with Alexa Fluor-488 phalloidin (green) for F-actin, rabbit anti-Tmod3 (red) for Tmod3, and Hoechst 33258 (blue) for nuclei. See the article by Sui et al on page 758.