Pier Mannuccio Mannucci,and members of the rVWF Ad Hoc Study Group,Christine Kempton,and members of the rVWF Ad Hoc Study Group,Carolyn Millar,and members of the rVWF Ad Hoc Study Group,Edward Romond,and members of the rVWF Ad Hoc Study Group,Amy Shapiro,and members of the rVWF Ad Hoc Study Group,Ingvild Birschmann,and members of the rVWF Ad Hoc Study Group,Margaret V. Ragni,and members of the rVWF Ad Hoc Study Group,Joan Cox Gill,and members of the rVWF Ad Hoc Study Group,Thynn Thynn Yee,and members of the rVWF Ad Hoc Study Group,Robert Klamroth,and members of the rVWF Ad Hoc Study Group,Wing-Yen Wong,and members of the rVWF Ad Hoc Study Group,Miranda Chapman,and members of the rVWF Ad Hoc Study Group,Werner Engl,and members of the rVWF Ad Hoc Study Group,Peter L. Turecek,and members of the rVWF Ad Hoc Study Group,Tobias M. Suiter,and members of the rVWF Ad Hoc Study Group,Bruce M. Ewenstein,and members of the rVWF Ad Hoc Study Group

View Articletitled, Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial

Supplemental data

GENE THERAPY

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization

Emília Ilona Gaál,Tuomas Tammela,Andrey Anisimov,Serge Marbacher,Petri Honkanen,Georgia Zarkada,Veli-Matti Leppänen,Turgut Tatlisumak,Juha Hernesniemi,Mika Niemelä,Kari Alitalo

View Articletitled, Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization

Supplemental data

IMMUNOBIOLOGY

The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse

Marinos Kallikourdis,Anna Elisa Trovato,Fabio Anselmi,Adelaida Sarukhan,Giuliana Roselli,Laura Tassone,Raffaele Badolato,Antonella Viola

View Articletitled, The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse

Supplemental data

CX3CR1 reduces Ly6C^high-monocyte motility within and release from the bone marrow after chemotherapy in mice

Sébastien Jacquelin,Fabrice Licata,Karim Dorgham,Patricia Hermand,Lucie Poupel,Elodie Guyon,Philippe Deterre,David A. Hume,Christophe Combadière,Alexandre Boissonnas

View Articletitled, CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice

Supplemental data

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

Nathalie Fiegler,Sonja Textor,Annette Arnold,Alexander Rölle,Ina Oehme,Kai Breuhahn,Gerhard Moldenhauer,Mathias Witzens-Harig,Adelheid Cerwenka

View Articletitled, Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

Supplemental data

LYMPHOID NEOPLASIA

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL

Deepika Kaveri,Philippe Kastner,Doulaye Dembélé,Claus Nerlov,Susan Chan,Peggy Kirstetter

View Articletitled, β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL

Supplemental data

Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

Paul E. Massa,Aida Paniccia,Ana Monegal,Ario de Marco,Maria Rescigno

View Articletitled, Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

Supplemental data

HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10

Masahiko Takahashi,Masaya Higuchi,Grace Naswa Makokha,Hideaki Matsuki,Manami Yoshita,Yuetsu Tanaka,Masahiro Fujii

View Articletitled, HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10

Supplemental data

A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma

Hakim Bouamar,Saman Abbas,An-Ping Lin,Long Wang,Daifeng Jiang,Kenneth N. Holder,Marsha C. Kinney,Scott Hunicke-Smith,Ricardo C. T. Aguiar

View Articletitled, A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma

Supplemental data

Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia
Brief Report

Paolo Strati,Michael J. Keating,William G. Wierda,Xavier C. Badoux,Steliana Calin,James M. Reuben,Susan O’Brien,Steven M. Kornblau,Hagop M. Kantarjian,Hui Gao,Alessandra Ferrajoli

View Articletitled, Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia

MYELOID NEOPLASIA

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas,Jason A. Powell,Francois Vergez,David H. Segal,Nhu-Y. N. Nguyen,Adele Baker,Tse-Chieh Teh,Emma F. Barry,Jean-Emmanuel Sarry,Erwin M. Lee,Tracy L. Nero,Anissa M. Jabbour,Giovanna Pomilio,Benjamin D. Green,Stéphane Manenti,Stefan P. Glaser,Michael W. Parker,Angel F. Lopez,Paul G. Ekert,Richard B. Lock,David C. S. Huang,Susie K. Nilsson,Christian Récher,Andrew H. Wei,Mark A. Guthridge

View Articletitled, Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Supplemental data

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Francis Mussai,Carmela De Santo,Issa Abu-Dayyeh,Sarah Booth,Lynn Quek,Rosanna M. McEwen-Smith,Amrana Qureshi,Francesco Dazzi,Paresh Vyas,Vincenzo Cerundolo

View Articletitled, Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Supplemental data

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression

Debleena Ray,So Yeon Kwon,Hiromi Tagoh,Olaf Heidenreich,Anetta Ptasinska,Constanze Bonifer

View Articletitled, Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue

Max Lerchenberger,Bernd Uhl,Konstantin Stark,Gabriele Zuchtriegel,Annekathrin Eckart,Meike Miller,Daniel Puhr-Westerheide,Marc Praetner,Markus Rehberg,Alexander G. Khandoga,Kirsten Lauber,Steffen Massberg,Fritz Krombach,Christoph A. Reichel

View Articletitled, Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue

Supplemental data

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Alfred D. Doyle,Elizabeth A. Jacobsen,Sergei I. Ochkur,Michael P. McGarry,Kevin G. Shim,David T. C. Nguyen,Cheryl Protheroe,Dana Colbert,Jake Kloeber,Joseph Neely,Kelly P. Shim,Kimberly D. Dyer,Helene F. Rosenberg,James J. Lee,Nancy A. Lee

View Articletitled, Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Supplemental data

PLATELETS AND THROMBOPOIESIS

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)

Lin Zhang,Nicole Urtz,Florian Gaertner,Kyle R. Legate,Tobias Petzold,Michael Lorenz,Alexandra Mazharian,Steve P. Watson,Steffen Massberg

View Articletitled, Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)

Supplemental data

Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy
Brief Report

Benjamin C. Lee,Chad L. Mayer,Caitlin S. Leibowitz,D. J. Stearns-Kurosawa,Shinichiro Kurosawa

View Articletitled, Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy

THROMBOSIS AND HEMOSTASIS

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

Laurent Burnier,Laurent O. Mosnier

View Articletitled, Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

Supplemental data

Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic review

David Garcia,Elie A. Akl,Richard Carr,Clive Kearon

View Articletitled, Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic review

TRANSPLANTATION

CC chemokine receptor 8 potentiates donor T_reg survival and is critical for the prevention of murine graft-versus-host disease

James M. Coghill,Kenneth A. Fowler,Michelle L. West,LeShara M. Fulton,Hendrik van Deventer,Karen P. McKinnon,Benjamin G. Vincent,Kaifeng Lin,Angela Panoskaltsis-Mortari,Donald N. Cook,Bruce R. Blazar,Jonathan S. Serody

View Articletitled, CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease

Supplemental data

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
Brief Report

Simone Dertschnig,Gretel Nusspaumer,Robert Ivanek,Mathias M. Hauri-Hohl,Georg A. Holländer,Werner Krenger

View Articletitled, Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD

Supplemental data

VASCULAR BIOLOGY

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Christopher A. Moxon,Samuel C. Wassmer,Danny A. Milner, Jr,Ngawina V. Chisala,Terrie E. Taylor,Karl B. Seydel,Malcolm E. Molyneux,Brian Faragher,Charles T. Esmon,Colin Downey,Cheng-Hock Toh,Alister G. Craig,Robert S. Heyderman

View Articletitled, Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Supplemental data

Cover Image

Cover Image

Acute myeloid leukemia cells carrying the t(8;21) translocation expressing a constitutively active KIT receptor on the surface (stained in red). Signaling via KIT abrogates polycomb repression of the B cell gene PAX5 in the nucleus (stained by DAPI) leading to its lineage inappropriate activation. See the article by Ray et al on page 759.
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Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPER

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

Measuring the symptom burden associated with the treatment of chronic myeloid leukemia Clinical Trials & Observations

Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial Clinical Trials & Observations

GENE THERAPY

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia Brief Report

MYELOID NEOPLASIA

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

PLATELETS AND THROMBOPOIESIS

Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy Brief Report

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD Brief Report

VASCULAR BIOLOGY

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This Feature Is Available To Subscribers Only

Measuring the symptom burden associated with the treatment of chronic myeloid leukemia
Clinical Trials & Observations

Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial
Clinical Trials & Observations

Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia
Brief Report

Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy
Brief Report

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
Brief Report