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In Wiskott-Aldrich syndrome, platelet count matters
Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome
A randomized phase 3 trial of thalidomide and prednisone as maintenance therapy after ASCT in patients with MM with a quality-of-life assessment: the National Cancer Institute of Canada Clinicals Trials Group Myeloma 10 Trial
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences
Issue Archive
February 28 2013
Table of Contents
Inside Blood
CLINICAL TRIALS & OBSERVATIONS
In Wiskott-Aldrich syndrome, platelet count matters
Clinical Trials & Observations
Blood Work
Plenary Paper
MYELOID NEOPLASIA
Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation
Julien Haroche,Fleur Cohen-Aubart,Jean-François Emile,Laurent Arnaud,Philippe Maksud,Frédéric Charlotte,Philippe Cluzel,Aurélie Drier,Baptiste Hervier,Neïla Benameur,Sophie Besnard,Jean Donadieu,Zahir Amoura
Review Article
Clinical Trials and Observations
Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome
Clinical Trials & Observations
Nizar Mahlaoui,Isabelle Pellier,Cécile Mignot,Jean-Philippe Jais,Chrystèle Bilhou-Nabéra,Despina Moshous,Bénédicte Neven,Capucine Picard,Geneviève de Saint-Basile,Marina Cavazzana-Calvo,Stéphane Blanche,Alain Fischer
A randomized phase 3 trial of thalidomide and prednisone as maintenance therapy after ASCT in patients with MM with a quality-of-life assessment: the National Cancer Institute of Canada Clinicals Trials Group Myeloma 10 Trial
Clinical Trials & Observations
A. Keith Stewart,Suzanne Trudel,Nizar J. Bahlis,Darrell White,Waleed Sabry,Andrew Belch,Tony Reiman,Jean Roy,Chaim Shustik,Michael J. Kovacs,Morel Rubinger,Guy Cantin,Kevin Song,Kirsty A. Tompkins,Deb C. Marcellus,Martha Q. Lacy,Jonathan Sussman,Donna Reece,Michael Brundage,Erica L. Harnett,Lois Shepherd,Judy-Anne W. Chapman,Ralph M. Meyer
Gene Therapy
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
Clinical Trials & Observations
Pablo Tebas,David Stein,Gwendolyn Binder-Scholl,Rithun Mukherjee,Troy Brady,Tessio Rebello,Laurent Humeau,Michael Kalos,Emmanouil Papasavvas,Luis J. Montaner,Daniel Schullery,Farida Shaheen,Andrea L. Brennan,Zhaohui Zheng,Julio Cotte,Vladimir Slepushkin,Elizabeth Veloso,Adonna Mackley,Wei-Ting Hwang,Faten Aberra,Jenny Zhan,Jean Boyer,Ronald G. Collman,Frederic D. Bushman,Bruce L. Levine,Carl H. June
Hematopoiesis and Stem Cells
Immunobiology
Lymphoid Neoplasia
Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma
Michael R. Green,Andrew J. Gentles,Ramesh V. Nair,Jonathan M. Irish,Shingo Kihira,Chih Long Liu,Itai Kela,Erik S. Hopmans,June H. Myklebust,Hanlee Ji,Sylvia K. Plevritis,Ronald Levy,Ash A. Alizadeh
Myeloid Neoplasia
Genomic impact of transient low-dose decitabine treatment on primary AML cells
Jeffery M. Klco,David H. Spencer,Tamara L. Lamprecht,Shawn M. Sarkaria,Todd Wylie,Vincent Magrini,Jasreet Hundal,Jason Walker,Nobish Varghese,Petra Erdmann-Gilmore,Cheryl F. Lichti,Matthew R. Meyer,R. Reid Townsend,Richard K. Wilson,Elaine R. Mardis,Timothy J. Ley
Phagocytes, Granulocytes, and Myelopoiesis
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences
e-blood
Fernando O. Martinez,Laura Helming,Ronny Milde,Audrey Varin,Barbro N. Melgert,Christina Draijer,Benjamin Thomas,Marco Fabbri,Anjali Crawshaw,Ling Pei Ho,Nick H. Ten Hacken,Viviana Cobos Jiménez,Neeltje A. Kootstra,Jörg Hamann,David R. Greaves,Massimo Locati,Alberto Mantovani,Siamon Gordon
Red Cells, Iron, and Erythropoiesis
Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity
Stephen C. Rogers,Jerlinda G. C. Ross,Andre d'Avignon,Lindsey B. Gibbons,Vered Gazit,Mojibade N. Hassan,Dylan McLaughlin,Sherraine Griffin,Tara Neumayr,Malcolm DeBaun,Michael R. DeBaun,Allan Doctor
Transfusion Medicine
Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia
Steven B. Solomon,Dong Wang,Junfeng Sun,Tamir Kanias,Jing Feng,Christine C. Helms,Michael A. Solomon,Meghna Alimchandani,Martha Quezado,Mark T. Gladwin,Daniel B. Kim-Shapiro,Harvey G. Klein,Charles Natanson
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Cover Image
Cover Image
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Immunofluorescence staining of HEp-2 cells by a representative recombinant antibody cloned from a mature naive B cell of a patient with IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome. The staining shows a cytoplasmic pattern, revealing antibody autoreactivity. The frequency of autoreactive clones is increased in mature naive B cells from IPEX patients who harbor nonfunctional regulatory T cells due to mutations in the forkhead box protein 3 (FOXP3) gene. See the article by Kinnunen et al on page 1595.
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