Cindy E. Neunert,for the Intercontinental Cooperative ITP Study Group Registry II Participants,George R. Buchanan,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Paul Imbach,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Paula H. B. Bolton-Maggs,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Carolyn M. Bennett,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Ellis Neufeld,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Sara K. Vesely,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Leah Adix,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Victor S. Blanchette,for the Intercontinental Cooperative ITP Study Group Registry II Participants,Thomas Kühne,for the Intercontinental Cooperative ITP Study Group Registry II Participants

View Articletitled, Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS)

Hematopoiesis and Stem Cells

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

Christos Gekas,Thomas Graf

View Articletitled, CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

Supplemental data

Immunobiology

MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections

Arif A. Khan,Laura A. Penny,Yevgeniy Yuzefpolskiy,Surojit Sarkar,Vandana Kalia

View Articletitled, MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections

Supplemental data

IL-7/anti–IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R

Christopher E. Martin,Ester M. M. van Leeuwen,Se Jin Im,Derry C. Roopenian,Young-Chul Sung,Charles D. Surh

View Articletitled, IL-7/anti–IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R

Supplemental data

Lymphoid Neoplasia

Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6

Mathias Witzens-Harig,Dirk Hose,Simone Jünger,Christina Pfirschke,Nisit Khandelwal,Ludmila Umansky,Anja Seckinger,Heinke Conrad,Bettina Brackertz,Thierry Rème,Brigitte Gueckel,Tobias Meißner,Michael Hundemer,Anthony D. Ho,Jean-Francois Rossi,Kai Neben,Helga Bernhard,Hartmut Goldschmidt,Bernard Klein,Philipp Beckhove

View Articletitled, Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6

Supplemental data

MYD88 L265P mutation in Waldenstrom macroglobulinemia

Stéphanie Poulain,Christophe Roumier,Audrey Decambron,Aline Renneville,Charles Herbaux,Elisabeth Bertrand,Sabine Tricot,Agnès Daudignon,Sylvie Galiègue-Zouitina,Valerie Soenen,Olivier Theisen,Nathalie Grardel,Olivier Nibourel,Catherine Roche-Lestienne,Bruno Quesnel,Patrick Duthilleul,Claude Preudhomme,Xavier Leleu

View Articletitled, MYD88 L265P mutation in Waldenstrom macroglobulinemia

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

Junli Yan,Siok-Bian Ng,Jim Liang-Seah Tay,Baohong Lin,Tze Loong Koh,Joy Tan,Viknesvaran Selvarajan,Shaw-Cheng Liu,Chonglei Bi,Shi Wang,Shoa-Nian Choo,Norio Shimizu,Gaofeng Huang,Qiang Yu,Wee-Joo Chng

View Articletitled, EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

Supplemental data

Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL

Anna Vardi,Antonis Dagklis,Lydia Scarfò,Diane Jelinek,Darren Newton,Fiona Bennett,Julia Almeida,Arancha Rodriguez-Caballero,Sallie Allgood,Mark Lanasa,Agostino Cortelezzi,Ester Orlandi,Silvio Veronese,Marco Montillo,Andy Rawstron,Tait Shanafelt,Alberto Orfao,Kostas Stamatopoulos,Paolo Ghia

View Articletitled, Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL

Supplemental data

Single nucleotide variation in the TP53 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program

Yong Li,Michael W. Gordon,Zijun Y. Xu-Monette,Carlo Visco,Alexander Tzankov,Dehui Zou,Lugui Qiu,Santiago Montes-Moreno,Karen Dybkaer,Attilio Orazi,Youli Zu,Govind Bhagat,Kristy L. Richards,Eric D. Hsi,William W. L. Choi,J. Han van Krieken,Qin Huang,Weiyun Ai,Maurilio Ponzoni,Andrés J. M. Ferreri,Jane N. Winter,Ronald S. Go,Miguel A. Piris,Michael B. Møller,Lin Wu,Michael Wang,Kenneth S. Ramos,L. Jeffrey Medeiros,Ken H. Young

View Articletitled, Single nucleotide variation in the TP53 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program

Supplemental data

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Hanna L. M. Rajala,Samuli Eldfors,Heikki Kuusanmäki,Arjan J. van Adrichem,Thomas Olson,Sonja Lagström,Emma I. Andersson,Andres Jerez,Michael J. Clemente,Yiyi Yan,Dan Zhang,Andy Awwad,Pekka Ellonen,Olli Kallioniemi,Krister Wennerberg,Kimmo Porkka,Jaroslaw P. Maciejewski,Thomas P. Loughran, Jr,Caroline Heckman,Satu Mustjoki

View Articletitled, Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Supplemental data

BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements
Brief Report

Zhengfei Lu,Albert G. Tsai,Takashi Akasaka,Hitoshi Ohno,Yanwen Jiang,Ari M. Melnick,Harvey A. Greisman,Michael R. Lieber

View Articletitled, BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements

Supplemental data

Platelets and Thrombopoiesis

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Mehran Ghasemzadeh,Zane S. Kaplan,Imala Alwis,Simone M. Schoenwaelder,Katrina J. Ashworth,Erik Westein,Ehteramolsadat Hosseini,Hatem H. Salem,Robyn Slattery,Shaun R. McColl,Michael J. Hickey,Zaverio M. Ruggeri,Yuping Yuan,Shaun P. Jackson

View Articletitled, The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Supplemental data

IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Zubair A. Karim,Jinchao Zhang,Meenakshi Banerjee,Michael C. Chicka,Rania Al Hawas,Tara R. Hamilton,Paul A. Roche,Sidney W. Whiteheart

View Articletitled, IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Supplemental data

Red Cells, Iron, and Erythropoiesis

Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation

LiQi Li,Johannes Freudenberg,Kairong Cui,Ryan Dale,Sang-Hyun Song,Ann Dean,Keji Zhao,Raja Jothi,Paul E. Love

View Articletitled, Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation

Supplemental data

Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia
e-blood

Settara C. Chandrasekharappa,and NISC Comparative Sequencing Program5,Francis P. Lach,and NISC Comparative Sequencing Program5,Danielle C. Kimble,and NISC Comparative Sequencing Program5,Aparna Kamat,and NISC Comparative Sequencing Program5,Jamie K. Teer,and NISC Comparative Sequencing Program5,Frank X. Donovan,and NISC Comparative Sequencing Program5,Elizabeth Flynn,and NISC Comparative Sequencing Program5,Shurjo K. Sen,and NISC Comparative Sequencing Program5,Supawat Thongthip,and NISC Comparative Sequencing Program5,Erica Sanborn,and NISC Comparative Sequencing Program5,Agata Smogorzewska,and NISC Comparative Sequencing Program5,Arleen D. Auerbach,and NISC Comparative Sequencing Program5,Elaine A. Ostrander,and NISC Comparative Sequencing Program5

View Articletitled, Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia

Supplemental data

Thrombosis and Hemostasis

LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA₂ synthesis, platelet activation, and thrombosis

Brian Estevez,Aleksandra Stojanovic-Terpo,M. Keegan Delaney,Kelly A. O’Brien,Michael C. Berndt,Changgeng Ruan,Xiaoping Du

View Articletitled, LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA2 synthesis, platelet activation, and thrombosis

Transplantation

Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice

Amar Nijagal,Chris Derderian,Tom Le,Erin Jarvis,Linda Nguyen,Qizhi Tang,Tippi C. MacKenzie

View Articletitled, Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice

Supplemental data

Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation

Marcelo A. Fernández-Viña,John P. Klein,Michael Haagenson,Stephen R. Spellman,Claudio Anasetti,Harriet Noreen,Lee Ann Baxter-Lowe,Pedro Cano,Neal Flomenberg,Dennis L. Confer,Mary M. Horowitz,Machteld Oudshoorn,Effie W. Petersdorf,Michelle Setterholm,Richard Champlin,Stephanie J. Lee,Marcos de Lima

View Articletitled, Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation

Supplemental data

Cover Image

Cover Image

The foreground image (from PDB structure 4E9G) shows the thymine in a T:G mismatch everted and poised for cleavage by the glycosylase domain of human MBD4. Base excision is postulated to be a crucial step leading to chromosomal breakage in B cell lymphoma translocations, following DNA deamination by AID. The background image shows a “double-hit” B cell lymphoma with both BCL2 and MYC translocations. See the article by Lu et al on page 4551.
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