Issue Archive

In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by corneal epithelial cells; they show that sVEGFR-3 modulates lymphangiogenesis by impounding vascular endothelial growth factor (VEGF) C and rendering it unable to activate its cognate receptors, thereby maintaining the natural alymphatic disposition of the cornea (see figure).¹ 

In this issue of Blood, Shanafelt and colleagues demonstrate that T-cell immune synapse function can be increased in chronic lymphocytic leukemia (CLL), both by reducing tumor burden with immunochemotherapy and by lenalidomide.¹ 

In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the β₂-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation.¹ 

In this issue of Blood, Mazharian and colleagues characterize Shp1 and Shp2 conditional knockout (KO) murine models, underscoring the role of these phosphatases not only on platelet function but also on megakaryocyte development and platelet counts and size.¹