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Inside Blood

VASCULAR BIOLOGY

In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by corneal epithelial cells; they show that sVEGFR-3 modulates lymphangiogenesis by impounding vascular endothelial growth factor (VEGF) C and rendering it unable to activate its cognate receptors, thereby maintaining the natural alymphatic disposition of the cornea (see figure).1 

INSIDE BLOOD

In this issue of Blood, Shanafelt and colleagues demonstrate that T-cell immune synapse function can be increased in chronic lymphocytic leukemia (CLL), both by reducing tumor burden with immunochemotherapy and by lenalidomide.1 

PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS

In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the β2-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation.1 

PLATELETS & THROMBOPOIESIS

In this issue of Blood, Mazharian and colleagues characterize Shp1 and Shp2 conditional knockout (KO) murine models, underscoring the role of these phosphatases not only on platelet function but also on megakaryocyte development and platelet counts and size.1 

Blood Work

Plenary Paper

Blood Spotlight

Review Article

Clinical Trials and Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Thrombosis and Hemostasis

Transplantation

Vascular Biology

Continuing Medical Education (CME) Questions

  • Cover Image

    Cover Image

    issue cover

    Degradation-resistant HOXB4 protein augments the expansion of burst-forming erythroid (BFU-E) cells. Shown is a BFU-E colony derived from G-CSF-mobilized CD34+ cells following the administration of degradation-resistant recombinant HOXB4 protein and quantified using a colony-forming cell assay. Prolonging the half-life of transduced HOXB4 protein preferentially increases the size and number of BFU-E colonies compared with wild-type HOXB4 protein, indicating that attenuation of HOXB4 destruction by the CUL4 ubiquitin ligase helps maintain G-CSF-mobilized CD34+ cells in a primitive state. See the article by Lee et al on page 4082.

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