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Issue Archive

Volume 121, Issue 16
April 18 2013
Issue Cover

Table of Contents

Editorial

Epigenetics in hematology: introducing a collection of reviews
Margaret A. Goodell
View Articletitled, Epigenetics in hematology: introducing a collection of reviews

Inside Blood

THROMBOSIS & HEMOSTASIS
CD39 target practice
Debra K. Newman
View Articletitled, CD39 target practice
INSIDE BLOOD
Multiethnic myeloma
Brendan M. Weiss
View Articletitled, Multiethnic myeloma
RED CELLS, IRON, & ERYTHROPOIESIS
Another path to ERK activation
Paul A. Ney
View Articletitled, Another path to ERK activation

Blood Work

Hereditary elliptocytosis
Craig Soderquist,Adam Bagg
View Articletitled, Hereditary elliptocytosis

Plenary Paper

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?
Jan David Hohmann,Xiaowei Wang,Stefanie Krajewski,Carly Selan,Carolyn A. Haller,Andreas Straub,Elliot L. Chaikof,Harshal H. Nandurkar,Christoph E. Hagemeyer,Karlheinz Peter
View Articletitled, Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?
Supplemental data

Review Series

The role of chromatin modifiers in normal and malignant hematopoiesis
Jill S. Butler,Sharon Y. R. Dent
View Articletitled, The role of chromatin modifiers in normal and malignant hematopoiesis

How I Treat

How I treat patients with indolent and smoldering mastocytosis (rare conditions but difficult to manage)
Animesh Pardanani
View Articletitled, How I treat patients with indolent and smoldering mastocytosis (rare conditions but difficult to manage)

Clinical Trials and Observations

Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia
Clinical Trials & Observations
Masamitsu Yanada,Motohiro Tsuzuki,Hiroyuki Fujita,Katsumichi Fujimaki,Shin Fujisawa,Kazutaka Sunami,Masafumi Taniwaki,Akira Ohwada,Kosuke Tsuboi,Akio Maeda,Akihiro Takeshita,Shigeki Ohtake,Yasushi Miyazaki,Yoshiko Atsuta,Yukio Kobayashi,Tomoki Naoe,Nobuhiko Emi,on behalf of the Japan Adult Leukemia Study Group
View Articletitled, Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia

Immunobiology

IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Julien J. Karrich,Loes C. M. Jachimowski,Maho Nagasawa,Angela Kamp,Melania Balzarolo,Monika C. Wolkers,Christel H. Uittenbogaart,S. Marieke van Ham,Bianca Blom
View Articletitled, IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Supplemental data
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ
Elisabeth Salzer,Elisangela Santos-Valente,Stefanie Klaver,Sol A. Ban,Wolfgang Emminger,Nina Kathrin Prengemann,Wojciech Garncarz,Leonhard Müllauer,Renate Kain,Heidrun Boztug,Andreas Heitger,Klaus Arbeiter,Franz Eitelberger,Markus G. Seidel,Wolfgang Holter,Arnold Pollak,Winfried F. Pickl,Elisabeth Förster-Waldl,Kaan Boztug
View Articletitled, B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ
Supplemental data
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
Hye Sun Kuehn,Julie E. Niemela,Andreia Rangel-Santos,Mingchang Zhang,Stefania Pittaluga,Jennifer L. Stoddard,Ashleigh A. Hussey,Moses O. Evbuomwan,Debra A. Long Priel,Douglas B. Kuhns,C. Lucy Park,Thomas A. Fleisher,Gulbu Uzel,João B. Oliveira
View Articletitled, Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
Supplemental data
Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells
Rossana Trotta,Li Chen,Stefan Costinean,Srirama Josyula,Bethany L. Mundy-Bosse,David Ciarlariello,Charlene Mao,Edward L. Briercheck,Kathleen K. McConnell,Anjali Mishra,Lianbo Yu,Carlo M. Croce,Michael A. Caligiuri
View Articletitled, Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function
Rebecca M. May,Mariko Okumura,Chin-Jung Hsu,Hamid Bassiri,Enjun Yang,Gregory Rak,Emily M. Mace,Naomi H. Philip,Weiguo Zhang,Tobias Baumgart,Jordan S. Orange,Kim E. Nichols,Taku Kambayashi
View Articletitled, Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function
Supplemental data

Lymphoid Neoplasia

Uncovering the biology of multiple myeloma among African Americans: a comprehensive genomics approach
Angela Baker,Esteban Braggio,Susanna Jacobus,Sungwon Jung,Dirk Larson,Terry Therneau,Angela Dispenzieri,Scott A. Van Wier,Gregory Ahmann,Joan Levy,Louise Perkins,Seungchan Kim,Kimberly Henderson,David Vesole,S. Vincent Rajkumar,Diane F. Jelinek,John Carpten,Rafael Fonseca
View Articletitled, Uncovering the biology of multiple myeloma among African Americans: a comprehensive genomics approach
Supplemental data
Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence
Bettina R. Bonn,Marius Rohde,Martin Zimmermann,David Krieger,Ilske Oschlies,Felix Niggli,Grazyna Wrobel,Andishe Attarbaschi,Gabriele Escherich,Wolfram Klapper,Alfred Reiter,Birgit Burkhardt
View Articletitled, Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence
Supplemental data
The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma
Brief Report
Barbara Meissner,Robert Kridel,Raymond S. Lim,Sanja Rogic,Kane Tse,David W. Scott,Richard Moore,Andy J. Mungall,Marco A. Marra,Joseph M. Connors,Christian Steidl,Randy D. Gascoyne
View Articletitled, The E3 ubiquitin ligase <em>UBR5</em> is recurrently mutated in mantle cell lymphoma
Supplemental data

Myeloid Neoplasia

Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD
Catherine C. Smith,Elisabeth A. Lasater,Xiaotian Zhu,Kimberly C. Lin,Whitney K. Stewart,Lauren E. Damon,Sara Salerno,Neil P. Shah
View Articletitled, Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD
Supplemental data
Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia
Chieh-Lung Cheng,Hsin-An Hou,Ming-Cheng Lee,Chieh-Yu Liu,Jie-Yang Jhuang,Yan-Jun Lai,Chung-Wu Lin,Huan-Yuan Chen,Fu-Tong Liu,Wen-Chien Chou,Chien-Yuan Chen,Jih-Luh Tang,Ming Yao,Shang-Yi Huang,Bor-Sheng Ko,Shang-Ju Wu,Woei Tsay,Hwei-Fang Tien
View Articletitled, Higher bone marrow <em>LGALS3</em> expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia
Supplemental data
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome
Brief Report
Tsutomu Toki,Rika Kanezaki,Eri Kobayashi,Hiroshi Kaneko,Mikiko Suzuki,RuNan Wang,Kiminori Terui,Hirokazu Kanegane,Miho Maeda,Mikiya Endo,Tatsuki Mizuochi,Souichi Adachi,Yasuhide Hayashi,Masayuki Yamamoto,Ritsuko Shimizu,Etsuro Ito
View Articletitled, Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human
Yu-Hsun Lo,Yu-Wen Huang,Yung-Hsuan Wu,Chi-Shan Tsai,Yu-Chuan Lin,Shu-Ting Mo,Wen-Chih Kuo,Ya-Ting Chuang,Si-Tse Jiang,Hsiu-Ming Shih,Ming-Zong Lai
View Articletitled, Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human
Supplemental data
Aryl hydrocarbon receptor controls murine mast cell homeostasis
Yufeng Zhou,Hui-Ying Tung,Ying-Ming Tsai,Shih-Chang Hsu,Hui-Wen Chang,Hirokazu Kawasaki,Hsiao-Chun Tseng,Beverly Plunkett,Peisong Gao,Chih-Hsing Hung,Becky M. Vonakis,Shau-Ku Huang
View Articletitled, Aryl hydrocarbon receptor controls murine mast cell homeostasis
Supplemental data

Platelets and Thrombopoiesis

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
Alexander Zaslavsky,Stella T. Chou,Keri Schadler,Allyson Lieberman,Maxim Pimkin,Yeo Jung Kim,Kwan-Hyuck Baek,William C. Aird,Mitchell J. Weiss,Sandra Ryeom
View Articletitled, The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
Supplemental data

Red Cells, Iron, and Erythropoiesis

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway
Chutima Kumkhaek,Wulin Aerbajinai,Wenli Liu,Jianqiong Zhu,Naoya Uchida,Roger Kurlander,Matthew M. Hsieh,John F. Tisdale,Griffin P. Rodgers
View Articletitled, MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34<sup>+</sup> cells through the Raf/MEK/ERK pathway
Supplemental data
The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Zhiying Zou,David R. Enis,Hung Bui,Eugene Khandros,Vinayak Kumar,Zoltan Jakus,Christopher Thom,Yiqing Yang,Veerpal Dhillon,Mei Chen,MinMin Lu,Mitchell J. Weiss,Mark L. Kahn
View Articletitled, The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Supplemental data
Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia
Jonathan M. Flanagan,Vivien Sheehan,Heidi Linder,Thad A. Howard,Yong-Dong Wang,Carolyn C. Hoppe,Banu Aygun,Robert J. Adams,Geoffrey A. Neale,Russell E. Ware
View Articletitled, Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia
Supplemental data
Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo
Jingping Hu,Jing Liu,Fumin Xue,Gregory Halverson,Marion Reid,Anqi Guo,Lixiang Chen,Azra Raza,Naomi Galili,Julie Jaffray,Joseph Lane,Joel Anne Chasis,Naomi Taylor,Narla Mohandas,Xiuli An
View Articletitled, Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo
Supplemental data

Thrombosis and Hemostasis

Evidence that fibrinogen γ′ regulates plasma clot structure and lysis and relationship to cardiovascular risk factors in black Africans
Marlien Pieters,Retha C. Kotze,Johann C. Jerling,Annamarie Kruger,Robert A. S. Ariëns
View Articletitled, Evidence that fibrinogen γ′ regulates plasma clot structure and lysis and relationship to cardiovascular risk factors in black Africans
Supplemental data

Transfusion Medicine

Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants
CME
Rachael P. Jackman,Xutao Deng,Douglas Bolgiano,Mila Lebedeva,John W. Heitman,Michael P. Busch,Sherrill J. Slichter,Philip J. Norris
View Articletitled, Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants
Supplemental data

Transplantation

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder
Taku Sato,Mahoko Ikeda,Satoshi Yotsumoto,Yohta Shimada,Takashi Higuchi,Hiroshi Kobayashi,Takahiro Fukuda,Toya Ohashi,Toshio Suda,Toshiaki Ohteki
View Articletitled, Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder
Supplemental data
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
Doanh Le Huu,Takashi Matsushita,Guihua Jin,Yasuhito Hamaguchi,Minoru Hasegawa,Kazuhiko Takehara,Thomas F. Tedder,Manabu Fujimoto
View Articletitled, Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial
Brief Report
Peter Dreger,Andrea Schnaiter,Thorsten Zenz,Sebastian Böttcher,Marianna Rossi,Peter Paschka,Andreas Bühler,Sascha Dietrich,Raymonde Busch,Matthias Ritgen,Donald Bunjes,Matthias Zeis,Michael Stadler,Lutz Uharek,Christof Scheid,Ute Hegenbart,Michael Hallek,Michael Kneba,Norbert Schmitz,Hartmut Döhner,Stephan Stilgenbauer
View Articletitled, <em>TP53</em>, <em>SF3B1</em>, and <em>NOTCH1</em> mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial
Supplemental data

Vascular Biology

VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice
Špela Ferjančič,Ana M. Gil-Bernabé,Sally A. Hill,Philip D. Allen,Peter Richardson,Tim Sparey,Edward Savory,Jane McGuffog,Ruth J. Muschel
View Articletitled, VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice
Supplemental data

Retractions

Zhang C, Yang Y. Microparticles are the basic storage units for different proteins in platelet granules [published online ahead of print July 24, 2012]. Blood. doi: 10.1182/blood-2012-04-422907.
View Articletitled, Zhang C, Yang Y. Microparticles are the basic storage units for different proteins in platelet granules [published online ahead of print July 24, 2012]. <em>Blood</em>. doi: <span class="related-article">10.1182/blood-2012-04-422907</span>.

Continuing Medical Education (CME) Questions

Continuing Medical Education (CME) questions: HLA Abs and platelet refractoriness
CME
View Articletitled, Continuing Medical Education (CME) questions: HLA Abs and platelet refractoriness
All Issues

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