Skip to Main Content

Advertisement

Issue Archive

Table of Contents

Inside Blood

INSIDE BLOOD
CLINICAL TRIALS & OBSERVATIONS
HEMATOPOIESIS & STEM CELLS
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
PLATELETS & THROMBOPOIESIS
VASCULAR BIOLOGY

Blood Work

Plenary Paper

Perspectives

Review Article

Clinical Trials and Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Transplantation

Vascular Biology

  • Cover Image

    Cover Image

    issue cover

    The cover shows a megakaryocyte from a WASp null mouse with filamentous actin (labeled red) and vinculin (labeled green). WASp null megakaryocytes do not form podosomes, but rather show actin fibers and diffuse vinculin staining. The authors describe how podosomes form when normal megakaryocytes adhere to collagen matrix or native basement membrane. Podosomes contain highly dynamic actin networks formed when WASp is activated, as well as integrin based adhesions. They function in migration and matrix remodelling via metalloproteases. The authors propose that podosomes facilitate the extension of proplatelet arms through vessel walls for platelet production. See the article by Schachtner et al on page 2542.

  • PDF Icon PDF LinkFront Matter
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkBack Matter
  • PDF Icon PDF LinkAdvertising
  • PDF Icon PDF LinkEditorial Board
Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal

Advertisement