Nicola Gökbuget,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Michael Kneba,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Thorsten Raff,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Heiko Trautmann,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Claus-Rainer Bartram,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Renate Arnold,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Rainer Fietkau,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Mathias Freund,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Arnold Ganser,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Wolf-Dieter Ludwig,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Georg Maschmeyer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Harald Rieder,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Stefan Schwartz,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Hubert Serve,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Eckhard Thiel,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Monika Brüggemann,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Dieter Hoelzer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia

View Articletitled, Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

Supplemental data

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Yu-Tzu Tai,Betty Y. Chang,Sun-Young Kong,Mariateresa Fulciniti,Guang Yang,Yolanda Calle,Yiguo Hu,Jianhong Lin,Jian-Jun Zhao,Antonia Cagnetta,Michele Cea,Michael A. Sellitto,Mike Y. Zhong,Qiuju Wang,Chirag Acharya,Daniel R. Carrasco,Joseph J. Buggy,Laurence Elias,Steven P. Treon,William Matsui,Paul Richardson,Nikhil C. Munshi,Kenneth C. Anderson

View Articletitled, Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Supplemental data

Myeloid Neoplasia

Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice

Dongqing Yan,Robert E. Hutchison,Golam Mohi

View Articletitled, Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice

Supplemental data

Platelets and Thrombopoiesis

VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis

Wilko Thiele,Jaya Krishnan,Melanie Rothley,Debra Weih,Diana Plaumann,Vanessa Kuch,Luca Quagliata,Herbert A. Weich,Jonathan P. Sleeman

View Articletitled, VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis

Supplemental data

Red Cells, Iron, and Erythropoiesis

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

Ryan Zarychanski,Vincent P. Schulz,Brett L. Houston,Yelena Maksimova,Donald S. Houston,Brian Smith,Jesse Rinehart,Patrick G. Gallagher

View Articletitled, Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

Supplemental data

Treatment of erythropoietin deficiency in mice with systemically administered siRNA

William Querbes,Roman L. Bogorad,Javid Moslehi,Jamie Wong,Amy Y. Chan,Elena Bulgakova,Satya Kuchimanchi,Akin Akinc,Kevin Fitzgerald,Victor Koteliansky,William G. Kaelin, Jr

View Articletitled, Treatment of erythropoietin deficiency in mice with systemically administered siRNA

Supplemental data

Thrombosis and Hemostasis

Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity

Gary E. Gilbert,Valerie A. Novakovic,Randal J. Kaufman,Hongzhi Miao,Steven W. Pipe

View Articletitled, Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity

Supplemental data

Transplantation

Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms

Satoru Otsuru,Patricia L. Gordon,Kengo Shimono,Reena Jethva,Roberta Marino,Charlotte L. Phillips,Ted J. Hofmann,Elena Veronesi,Massimo Dominici,Masahiro Iwamoto,Edwin M. Horwitz

View Articletitled, Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms

Supplemental data

Vascular Biology

ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

Guoquan Liu,Aaron T. Place,Zhenlong Chen,Viktor M. Brovkovych,Stephen M. Vogel,William A. Muller,Randal A. Skidgel,Asrar B. Malik,Richard D. Minshall

View Articletitled, ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

Supplemental data

Correspondence

Malignancies are the major cause of death in patients with adult onset common variable immunodeficiency

Isabella Quinti,Carlo Agostini,Stefano Tabolli,Grazia Brunetti,Francesco Cinetto,Antonio Pecoraro,Giuseppe Spadaro

View Articletitled, Malignancies are the major cause of death in patients with adult onset common variable immunodeficiency

Seasonal and pandemic (A/H1N1 2009) MF-59–adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens

Davide Bedognetti,Filippo Ansaldi,Elisa Zanardi,Paolo Durando,Mario Roberto Sertoli,Carlotta Massucco,Enrico Balleari,Omar Racchi,Gabriele Zoppoli,Andrea Orsi,Cristiano Alicino,Giancarlo Icardi,Francesco M. Marincola,Simonetta Zupo,Manlio Ferrarini,Andrea De Maria

View Articletitled, Seasonal and pandemic (A/H1N1 2009) MF-59–adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens

Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl

Fabien Touzot,Liliane Dal-Cortivo,Virginie Verkarre,Annick Lim,Anne Crucis-Armengaud,Despina Moshous,Sébastien Héritier,Pierre Frange,Sophie Kaltenbach,Stéphane Blanche,Capucine Picard,Salima Hacein-Bey-Abina,Marina Cavazzana-Calvo,Alain Fischer

View Articletitled, Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl

Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response

Laurence Legros,Philippe Rousselot,Stéphane Giraudier,Michel Tulliez,Françoise Huguet,Franck-Emmanuel Nicolini,Francois-Xavier Mahon

View Articletitled, Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response

Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

Harold T. Bae,Clinton T. Baldwin,Paola Sebastiani,Marilyn J. Telen,Allison Ashley-Koch,Melanie Garrett,W. Craig Hooper,Christopher J. Bean,Michael R. DeBaun,Dan E. Arking,Pallav Bhatnagar,James F. Casella,Jeffrey Renn Keefer,Emily Barron-Casella,Victor Gordeuk,Gregory J. Kato,Caterina Minniti,James Taylor,Andrew Campbell,Lori Luchtman-Jones,Carolyn Hoppe,Mark T. Gladwin,Yingze Zhang,Martin H. Steinberg

View Articletitled, Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

Errata

Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16):4384–4393.

View Articletitled, Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16):4384–4393.

San-Miguel JF. Consolidation therapy in myeloma: a consolidated approach? Blood. 2012;120(1):2–3.

View Articletitled, San-Miguel JF. Consolidation therapy in myeloma: a consolidated approach? Blood. 2012;120(1):2–3.

Cover Image

Cover Image

Wright-stained peripheral blood smear demonstrating eccentrocytes (cells with eccentric hemoglobin puddling), stomatocytes, and reticulocytes. This morphology is typical of hereditary xerocytosis, an inherited disorder of erythrocyte dehydration. Mutations in the FAM38A gene, which encodes the membrane-associated mechanotransduction protein, PIEZO1, have been identified in patients with hereditary xerocytosis. See the article by Zarychanski et al on page 1908.
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Issue Archive

Table of Contents

Inside Blood

Blood Work

Plenary Paper

Perspectives

Review Article

How I Treat

Clinical Trials and Observations

A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma Clinical Trials & Observations

Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome Clinical Trials & Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma Brief Report

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies Clinical Trials & Observations

Myeloid Neoplasia

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transplantation

Vascular Biology

Correspondence

Errata

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ASH Publications

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A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
Clinical Trials & Observations

Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome
Clinical Trials & Observations

Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma
Brief Report

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies
Clinical Trials & Observations