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Issue Archive

Volume 120, Issue 24
December 6 2012
Issue Cover

Table of Contents

Inside Blood

IMMUNOBIOLOGY
Toward a prime-boost regime for NK cells?
Karl-Johan Malmberg
View Articletitled, Toward a prime-boost regime for NK cells?
IMMUNOBIOLOGY
Gone baby gone—but how?
Charles G. Drake
View Articletitled, Gone baby gone—but how?
PLATELETS & THROMBOPOIESIS
Dynamin 3 and platelet size variation
Alan B. Cantor
View Articletitled, Dynamin 3 and platelet size variation
PLATELETS & THROMBOPOIESIS
Platelets signal and tumors take off
A. Koneti Rao,Deepak A. Rao
View Articletitled, Platelets signal and tumors take off
TRANSPLANTATION
IL-7 earns her ticket in allo-HSCT
Antoine Toubert
View Articletitled, IL-7 earns her ticket in allo-HSCT

Blood Work

Transient myeloproliferative disorder
Bushra Moiz,Maria Shafiq
View Articletitled, Transient myeloproliferative disorder
Like son, like father
Jayashree D. Kulkarni
View Articletitled, Like son, like father

Plenary Paper

IMMUNOBIOLOGY
IL-7–producing stromal cells are critical for lymph node remodeling
Lucas Onder,Priyanka Narang,Elke Scandella,Qian Chai,Maria Iolyeva,Kerim Hoorweg,Cornelia Halin,Ellen Richie,Paul Kaye,Jürgen Westermann,Tom Cupedo,Mark Coles,Burkhard Ludewig
View Articletitled, IL-7–producing stromal cells are critical for lymph node remodeling
Supplemental data

Review Articles

Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
Adrian Wiestner
View Articletitled, Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
Have drug combinations supplanted stem cell transplantation in myeloma?
Antonio Palumbo,Federica Cavallo
View Articletitled, Have drug combinations supplanted stem cell transplantation in myeloma?
Perioperative management of patients on chronic antithrombotic therapy
Thomas L. Ortel
View Articletitled, Perioperative management of patients on chronic antithrombotic therapy

Clinical Trials and Observations

Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)
Clinical Trials & Observations
Gert J. Ossenkoppele,Georg Stussi,Johan Maertens,Kees van Montfort,Bart J. Biemond,Dimitri Breems,August Ferrant,Carlos Graux,Georgine E. de Greef,C. J. M. Halkes,Mels Hoogendoorn,Rene M. Hollestein,Mojca Jongen-Lavrencic,Mark D. Levin,Arjan A. van de Loosdrecht,Marinus van Marwijk Kooij,Yvette van Norden,Thomas Pabst,Harry C. Schouten,Edo Vellenga,Gregor E. G. Verhoef,Okke de Weerdt,Pierre Wijermans,Jakob R. Passweg,Bob Löwenberg
View Articletitled, Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)
Supplemental data
Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases
Clinical Trials & Observations
Javier A. Laurini,Anamarija M. Perry,Eugene Boilesen,Jacques Diebold,Kenneth A. MacLennan,H. Konrad Müller-Hermelink,Bharat N. Nathwani,James O. Armitage,Dennis D. Weisenburger
View Articletitled, Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases
Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia
Clinical Trials & Observations
Alfonso Quintás-Cardama,Farhad Ravandi,Theresa Liu-Dumlao,Mark Brandt,Stefan Faderl,Sherry Pierce,Gautam Borthakur,Guillermo Garcia-Manero,Jorge Cortes,Hagop Kantarjian
View Articletitled, Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia
Supplemental data

Hematopoiesis and Stem Cells

Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model
Dong Li,Hong Yang,Hong Nan,Peng Liu,Sulei Pang,Qian Zhao,Rotem Karni,Mark P. Kamps,Yuanfu Xu,Jiaxi Zhou,Therese Wiedmer,Peter J. Sims,Fei Wang
View Articletitled, Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model
Supplemental data
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function
Veneta Krasteva,Manuel Buscarlet,Abigail Diaz-Tellez,Marie-Anne Bernard,Gerald R. Crabtree,Julie A. Lessard
View Articletitled, The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function
Supplemental data

Immunobiology

Spi-B is critical for plasmacytoid dendritic cell function and development
Izumi Sasaki,Katsuaki Hoshino,Takahiro Sugiyama,Chihiro Yamazaki,Takahiro Yano,Akihiko Iizuka,Hiroaki Hemmi,Takashi Tanaka,Masuyoshi Saito,Masanaka Sugiyama,Yuri Fukuda,Tomokazu Ohta,Katsuaki Sato,Akira Ainai,Tadaki Suzuki,Hideki Hasegawa,Noriko Toyama-Sorimachi,Hiroshi Kohara,Takashi Nagasawa,Tsuneyasu Kaisho
View Articletitled, Spi-B is critical for plasmacytoid dendritic cell function and development
Supplemental data
Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
Zacarias Garcia,Fabrice Lemaître,Nico van Rooijen,Matthew L. Albert,Yves Levy,Olivier Schwartz,Philippe Bousso
View Articletitled, Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
Supplemental data
Cytokine activation induces human memory-like NK cells
Rizwan Romee,Stephanie E. Schneider,Jeffrey W. Leong,Julie M. Chase,Catherine R. Keppel,Ryan P. Sullivan,Megan A. Cooper,Todd A. Fehniger
View Articletitled, Cytokine activation induces human memory-like NK cells
Supplemental data
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells
Eric F. Tewalt,Jarish N. Cohen,Sherin J. Rouhani,Cynthia J. Guidi,Hui Qiao,Shawn P. Fahl,Mark R. Conaway,Timothy P. Bender,Kenneth S. Tung,Anthony T. Vella,Adam J. Adler,Lieping Chen,Victor H. Engelhard
View Articletitled, Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells
Supplemental data

Lymphoid Neoplasia

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
Jennifer Edelmann,Karlheinz Holzmann,Florian Miller,Dirk Winkler,Andreas Bühler,Thorsten Zenz,Lars Bullinger,Michael W. M. Kühn,Andreas Gerhardinger,Johannes Bloehdorn,Ina Radtke,Xiaoping Su,Jing Ma,Stanley Pounds,Michael Hallek,Peter Lichter,Jan Korbel,Raymonde Busch,Daniel Mertens,James R. Downing,Stephan Stilgenbauer,Hartmut Döhner
View Articletitled, High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
Supplemental data
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions
Piers E. M. Patten,Charles C. Chu,Emilia Albesiano,Rajendra N. Damle,Xiao-Jie Yan,Dorothy Kim,Lu Zhang,Amanda R. Magli,Jacqueline Barrientos,Jonathan E. Kolitz,Steven L. Allen,Kanti R. Rai,Sergio Roa,Patricia K. Mongini,Thomas MacCarthy,Matthew D. Scharff,Nicholas Chiorazzi
View Articletitled, IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions
Supplemental data

Myeloid Neoplasia

Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes
Aparna Raval,Kunju J. Sridhar,Shripa Patel,Brit B. Turnbull,Peter L. Greenberg,Beverly S. Mitchell
View Articletitled, Reduced rRNA expression and increased rDNA promoter methylation in CD34<sup>+</sup> cells of patients with myelodysplastic syndromes
Supplemental data
Frat2 mediates the oncogenic activation of Rac by MLL fusions
Vanessa Walf-Vorderwülbecke,Jasper de Boer,Sarah J. Horton,Renée van Amerongen,Natalie Proost,Anton Berns,Owen Williams
View Articletitled, Frat2 mediates the oncogenic activation of Rac by MLL fusions
Supplemental data
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine
Ying Gu,Ting Chen,Zhipeng Meng,Yichao Gan,Xiaohua Xu,Guiyu Lou,Hongzhi Li,Xiaoxian Gan,Hong Zhou,Jinfen Tang,Genbo Xu,Liansheng Huang,Xiaohong Zhang,Yongming Fang,Kai Wang,Shu Zheng,Wendong Huang,Rongzhen Xu
View Articletitled, CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine
Supplemental data
In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells
Brief Report
Erinn Soucie,Katia Hanssens,Thomas Mercher,Sophie Georgin-Lavialle,Gandhi Damaj,Cristina Livideanu,Maria Olivia Chandesris,Yolène Acin,Sebastien Létard,Paulo de Sepulveda,Olivier Hermine,Olivier A. Bernard,Patrice Dubreuil
View Articletitled, In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Human basophils interact with memory T cells to augment Th17 responses
Keiko Wakahara,Nobuyasu Baba,Vu Quang Van,Philippe Bégin,Manuel Rubio,Pasquale Ferraro,Benoît Panzini,Ramses Wassef,Raymond Lahaie,Yves Caussignac,Raja Tamaz,Carole Richard,Geneviève Soucy,Guy Delespesse,Marika Sarfati
View Articletitled, Human basophils interact with memory T cells to augment Th17 responses
Supplemental data
Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells
Susan Moir,Suk See De Ravin,Brian H. Santich,Jin Young Kim,Jacqueline G. Posada,Jason Ho,Clarisa M. Buckner,Wei Wang,Lela Kardava,Mary Garofalo,Beatriz E. Marciano,Jody Manischewitz,Lisa R. King,Surender Khurana,Tae-Wook Chun,Hana Golding,Anthony S. Fauci,Harry L. Malech
View Articletitled, Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells
Supplemental data

Platelets and Thrombopoiesis

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site
Sylvia T. Nürnberg,Augusto Rendon,Peter A. Smethurst,Dirk S. Paul,Katrin Voss,Jonathan N. Thon,Heather Lloyd-Jones,Jennifer G. Sambrook,Marloes R. Tijssen,the HaemGen Consortium,Joseph E. Italiano, Jr,Panos Deloukas,Berthold Gottgens,Nicole Soranzo,Willem H. Ouwehand
View Articletitled, A GWAS sequence variant for platelet volume marks an alternative <em>DNM3</em> promoter in megakaryocytes near a MEIS1 binding site
Supplemental data
Platelets increase the proliferation of ovarian cancer cells
Brief Report
Min Soon Cho,Justin Bottsford-Miller,Hernan G. Vasquez,Rebecca Stone,Behrouz Zand,Michael H. Kroll,Anil K. Sood,Vahid Afshar-Kharghan
View Articletitled, Platelets increase the proliferation of ovarian cancer cells

Thrombosis and Hemostasis

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
Jie Huang,Maria Sabater-Lleal,Folkert W. Asselbergs,David Tregouet,So-Youn Shin,Jingzhong Ding,Jens Baumert,Tiphaine Oudot-Mellakh,Lasse Folkersen,Andrew D. Johnson,Nicholas L. Smith,Scott M. Williams,Mohammad A. Ikram,Marcus E. Kleber,Diane M. Becker,Vinh Truong,Josyf C. Mychaleckyj,Weihong Tang,Qiong Yang,Bengt Sennblad,Jason H. Moore,Frances M. K. Williams,Abbas Dehghan,Günther Silbernagel,Elisabeth M. C. Schrijvers,Shelly Smith,Mahir Karakas,Geoffrey H. Tofler,Angela Silveira,Gerjan J. Navis,Kurt Lohman,Ming-Huei Chen,Annette Peters,Anuj Goel,Jemma C. Hopewell,John C. Chambers,Danish Saleheen,Per Lundmark,Bruce M. Psaty,Rona J. Strawbridge,Bernhard O. Boehm,Angela M. Carter,Christa Meisinger,John F. Peden,Joshua C. Bis,Barbara McKnight,John Öhrvik,Kent Taylor,Maria Grazia Franzosi,Udo Seedorf,Rory Collins,Anders Franco-Cereceda,Ann-Christine Syvänen,Alison H. Goodall,Lisa R. Yanek,Mary Cushman,Martina Müller-Nurasyid,Aaron R. Folsom,Saonli Basu,Nena Matijevic,Wiek H. van Gilst,Jaspal S. Kooner,Albert Hofman,John Danesh,Robert Clarke,James B. Meigs,DIAGRAM Consortium,Sekar Kathiresan,Muredach P. Reilly,CARDIoGRAM Consortium,Norman Klopp,Tamara B. Harris,Bernhard R. Winkelmann,Peter J. Grant,Hans L. Hillege,Hugh Watkins,C4D Consortium,Timothy D. Spector,Lewis C. Becker,Russell P. Tracy,Winfried März,Andre G. Uitterlinden,Per Eriksson,Francois Cambien,CARDIOGENICS Consortium,Pierre-Emmanuel Morange,Wolfgang Koenig,Nicole Soranzo,Pim van der Harst,Yongmei Liu,Christopher J. O'Donnell,Anders Hamsten
View Articletitled, Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
Supplemental data

Transplantation

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
Clinical Trials & Observations
Miguel-Angel Perales,Jenna D. Goldberg,Jianda Yuan,Guenther Koehne,Lauren Lechner,Esperanza B. Papadopoulos,James W. Young,Ann A. Jakubowski,Bushra Zaidi,Humilidad Gallardo,Cailian Liu,Teresa Rasalan,Jedd D. Wolchok,Therese Croughs,Michel Morre,Sean M. Devlin,Marcel R. M. van den Brink
View Articletitled, Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

Vascular Biology

Antagonism of VEGF-A–induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway
Soo Hyeon Kim,Young-Rak Cho,Hyeon-Ju Kim,Joa Sub Oh,Eun-Kyung Ahn,Hye-Jin Ko,Byung Joon Hwang,Seo-Jin Lee,Yongwan Cho,Yong Kee Kim,William G. Stetler-Stevenson,Dong-Wan Seo
View Articletitled, Antagonism of VEGF-A–induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway
Supplemental data

Errata

Ibrahim AR, Eliasson L, Apperley JF, et al. Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy. Blood. 2011;117(14):3733–3736.
View Articletitled, Ibrahim AR, Eliasson L, Apperley JF, et al. Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy. <em>Blood</em>. 2011;117(14):<span class="related-article">3733–3736</span>.
Isern J, He Z, Fraser ST, et al. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood. 2011;117(18):4924–4934.
View Articletitled, Isern J, He Z, Fraser ST, et al. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. <em>Blood</em>. 2011;117(18):<span class="related-article">4924–4934</span>.
Risitano AM, Notaro R, Pascariello C, et al. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood. 2012;119(26):6307–6316.
View Articletitled, Risitano AM, Notaro R, Pascariello C, et al. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. <em>Blood</em>. 2012;119(26):<span class="related-article">6307–6316</span>.
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