Nelson Leung,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Frank Bridoux,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Colin A. Hutchison,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Samih H. Nasr,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Paul Cockwell,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Jean-Paul Fermand,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Angela Dispenzieri,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Kevin W. Song,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Robert A. Kyle,on behalf of the International Kidney and Monoclonal Gammopathy Research Group

View Articletitled, Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant

Review Article

In vivo roles of factor XII

Thomas Renné,Alvin H. Schmaier,Katrin F. Nickel,Margareta Blombäck,Coen Maas

View Articletitled, In vivo roles of factor XII

Clinical Trials and Observations

Impact of hydroxyurea on clinical events in the BABY HUG trial
CME Clinical Trials & Observations

Courtney D. Thornburg,for the BABY HUG Investigators,Beatrice A. Files,for the BABY HUG Investigators,Zhaoyu Luo,for the BABY HUG Investigators,Scott T. Miller,for the BABY HUG Investigators,Ram Kalpatthi,for the BABY HUG Investigators,Rathi Iyer,for the BABY HUG Investigators,Phillip Seaman,for the BABY HUG Investigators,Jeffrey Lebensburger,for the BABY HUG Investigators,Ofelia Alvarez,for the BABY HUG Investigators,Bruce Thompson,for the BABY HUG Investigators,Russell E. Ware,for the BABY HUG Investigators,Winfred C. Wang,for the BABY HUG Investigators

View Articletitled, Impact of hydroxyurea on clinical events in the BABY HUG trial

Gene Therapy

T-cell receptor gene transfer exclusively to human CD8⁺ cells enhances tumor cell killing

Qi Zhou,Irene C. Schneider,Inan Edes,Annemarie Honegger,Patricia Bach,Kurt Schönfeld,Axel Schambach,Winfried S. Wels,Sabrina Kneissl,Wolfgang Uckert,Christian J. Buchholz

View Articletitled, T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

Supplemental data

Hematopoiesis and Stem Cells

Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo

Emma Rörby,Matilda Nifelt Hägerström,Ulrika Blank,Göran Karlsson,Stefan Karlsson

View Articletitled, Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo

Supplemental data

PTH expands short-term murine hemopoietic stem cells through T cells

Jau-Yi Li,Jonathan Adams,Laura M. Calvi,Timothy F. Lane,Richard DiPaolo,M. Neale Weitzmann,Roberto Pacifici

View Articletitled, PTH expands short-term murine hemopoietic stem cells through T cells

Supplemental data

Immunobiology

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

Haiyan S. Li,Cliff Y. Yang,Kalyan C. Nallaparaju,Huiyuan Zhang,Yong-Jun Liu,Ananda W. Goldrath,Stephanie S. Watowich

View Articletitled, The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

Supplemental data

SOCS3 promotes interleukin-17 expression of human T cells

Katja Kleinsteuber,Kerrin Heesch,Stefanie Schattling,Claudia Sander-Juelch,Ulrike Mock,Kristoffer Riecken,Boris Fehse,Bernhard Fleischer,Marc Jacobsen

View Articletitled, SOCS3 promotes interleukin-17 expression of human T cells

Supplemental data

Memory CD4⁺CCR5⁺ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1

Madeleine J. Bunders,Chris M. van der Loos,Paul L. Klarenbeek,John L. van Hamme,Kees Boer,Jim C. H. Wilde,Niek de Vries,Rene A. W. van Lier,Neeltje Kootstra,Steven T. Pals,Taco W. Kuijpers

View Articletitled, Memory CD4+CCR5+ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1

Supplemental data

Lymphoid Neoplasia

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
Clinical Trials & Observations

Don M. Benson, Jr,Craig C. Hofmeister,Swaminathan Padmanabhan,Attaya Suvannasankha,Sundar Jagannath,Rafat Abonour,Courtney Bakan,Pascale Andre,Yvonne Efebera,Jérôme Tiollier,Michael A. Caligiuri,Sherif S. Farag

View Articletitled, A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma

S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis

Nagaja Capitani,Laura Patrussi,Livio Trentin,Orso Maria Lucherini,Enrica Cannizzaro,Enrica Migliaccio,Federica Frezzato,Cristina Gattazzo,Francesco Forconi,Piergiuseppe Pelicci,Gianpietro Semenzato,Cosima T. Baldari

View Articletitled, S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis

Supplemental data

Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
Clinical Trials & Observations

Mamta Gupta,Matthew J. Maurer,Linda E. Wellik,Mark E. Law,Jing Jing Han,Nazan Ozsan,Ivana N. Micallef,Ahmet Dogan,Thomas E. Witzig

View Articletitled, Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP

Supplemental data

Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia

Charles Gawad,Francois Pepin,Victoria E. H. Carlton,Mark Klinger,Aaron C. Logan,David B. Miklos,Malek Faham,Gary Dahl,Norman Lacayo

View Articletitled, Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia

Supplemental data

A prospective study of circulating adipokine levels and risk of multiple myeloma
Brief Report

Jonathan N. Hofmann,Linda M. Liao,Michael N. Pollak,Ye Wang,Ruth M. Pfeiffer,Dalsu Baris,Gabriella Andreotti,Qing Lan,Ola Landgren,Nathaniel Rothman,Mark P. Purdue

View Articletitled, A prospective study of circulating adipokine levels and risk of multiple myeloma

Supplemental data

Myeloid Neoplasia

Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells
Clinical Trials & Observations

Tine Greve,Erik Clasen-Linde,Morten T. Andersen,Mette K. Andersen,Stine D. Sørensen,Mikkel Rosendahl,Elisabeth Ralfkiær,Claus Yding Andersen

View Articletitled, Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells

Supplemental data

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
Clinical Trials & Observations

Norbert Vey,Jean-Henri Bourhis,Nicolas Boissel,Dominique Bordessoule,Thomas Prebet,Aude Charbonnier,Anne Etienne,Pascale Andre,François Romagne,Don Benson,Herve Dombret,Daniel Olive

View Articletitled, A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo

Kan Chen,Hiroshi Nishi,Richard Travers,Naotake Tsuboi,Kimberly Martinod,Denisa D. Wagner,Radu Stan,Kevin Croce,Tanya N. Mayadas

View Articletitled, Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo

Supplemental data

Platelets and Thrombopoiesis

NPP4 is a procoagulant enzyme on the surface of vascular endothelium

Ronald A. Albright,William C. Chang,Donna Robert,Deborah L. Ornstein,Wenxiang Cao,Lynn Liu,Meredith E. Redick,J. Isaac Young,Enrique M. De La Cruz,Demetrios T. Braddock

View Articletitled, NPP4 is a procoagulant enzyme on the surface of vascular endothelium

Supplemental data

Correspondence

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia

Toby Eyre,Claire J. Schwab,Ross Kinstrie,Ann Keen McGuire,Jen Strefford,Andrew Peniket,Adam Mead,Tim Littlewood,Tessa L. Holyoake,Mhairi Copland,Anthony V. Moorman,Christine J. Harrison,Paresh Vyas

View Articletitled, Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia

Role of fecal calprotectin as biomarker of gastrointestinal GVHD after allogeneic stem cell transplantation

Patrizia Chiusolo,Elisabetta Metafuni,Sabrina Giammarco,Silvia Bellesi,Nicola Piccirillo,Chiara Fanali,Massimo Castagnola,Cecilia Zuppi,Teresa De Michele,Giuseppe Leone,Simona Sica

View Articletitled, Role of fecal calprotectin as biomarker of gastrointestinal GVHD after allogeneic stem cell transplantation

High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center

Stephanie B. Tsai,David C. Seldin,Karen Quillen,John L. Berk,Frederick L. Ruberg,Hans Meier-Ewert,J. Mark Sloan,Gheorghe Doros,Kathleen T. Finn,Martha Skinner,Vaishali Sanchorawala

View Articletitled, High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center

Errata

Johnson RM, Ravindranath Y, El-Alfy M, Goyette G Jr. Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: correlation with in vivo reduced glutathione concentration and membrane protein oxidation. Blood. 1994;83(4):1117–1123.

View Articletitled, Johnson RM, Ravindranath Y, El-Alfy M, Goyette G Jr. Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: correlation with in vivo reduced glutathione concentration and membrane protein oxidation. Blood. 1994;83(4):1117–1123.

Munari F, Lonardi S, Cassatella MA, et al. Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. Blood. 2011;117(24):6612–6616.

View Articletitled, Munari F, Lonardi S, Cassatella MA, et al. Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. Blood. 2011;117(24):6612–6616.

Swierczek SI, Piterkova L, Jelinek J, et al. Methylation of AR locus does not always reflect X chromosome inactivation state. Blood. 2012;119(13):e100–e109.

View Articletitled, Swierczek SI, Piterkova L, Jelinek J, et al. Methylation of AR locus does not always reflect X chromosome inactivation state. Blood. 2012;119(13):e100–e109.

Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3⁺ Treg cells that phenotypically mirror effector Th cells. Blood. 2012;119(19):4430–4440.

View Articletitled, Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood. 2012;119(19):4430–4440.

Other Departments

Continuing Medical Education (CME) questions: BABY HUG events
CME

View Articletitled, Continuing Medical Education (CME) questions: BABY HUG events

Cover Image

Cover Image

Surface analysis of a confocal image of postcapillary venules (shown in red) in the cremaster muscle of wild-type mice reveals engagement of Fcγ receptors by immune complexes deposited in tissue results in the generation of sytox-green positive neutrophil extracellular traps (NETs). These are present primarily in the extravascular space (shown in blue), with a small fraction also localizing within vessels (shown in green). See the article by Chen et al on page 4421.
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Issue Archive

Table of Contents

Inside Blood

Blood Work

Plenary Paper

HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease Clinical Trials & Observations

Perspectives

Review Article

Clinical Trials and Observations

Impact of hydroxyurea on clinical events in the BABY HUG trial CME Clinical Trials & Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma Clinical Trials & Observations

Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP Clinical Trials & Observations

A prospective study of circulating adipokine levels and risk of multiple myeloma Brief Report

Myeloid Neoplasia

Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells Clinical Trials & Observations

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission Clinical Trials & Observations

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Correspondence

Errata

Other Departments

Continuing Medical Education (CME) questions: BABY HUG events CME

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease
Clinical Trials & Observations

Impact of hydroxyurea on clinical events in the BABY HUG trial
CME Clinical Trials & Observations

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
Clinical Trials & Observations

Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
Clinical Trials & Observations

A prospective study of circulating adipokine levels and risk of multiple myeloma
Brief Report

Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells
Clinical Trials & Observations

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
Clinical Trials & Observations

Continuing Medical Education (CME) questions: BABY HUG events
CME