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Inside Blood

INSIDE BLOOD
MYELOID NEOPLASIA
THROMBOSIS & HEMOSTASIS

Blood Work

Plenary Paper

PLENARY PAPER

Review Article

Clinical Trials and Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

MYELOID NEOPLASIA

Thrombosis and Hemostasis

Transplantation

Vascular Biology

Correspondence

  • Cover Image

    Cover Image

    issue cover

    During developmental angiogenesis, arterial maturation is regulated by Jagged1 expression on endothelial cells, which attracts nearby perivascular cells by activating a Notch signaling pathway. As a result, the perivascular cells up-regulate integrin αvβ3, resulting in their adhesion and spreading on von Willebrand factor selectively localized to the vascular basement membrane. The image shows blood vessels in a developing mouse retina at postnatal day 6. Endothelial cells (CD31, blue) on capillaries are covered by perivascular cells (NG2, red), while arteries recruit vascular smooth muscle cells (α-smooth muscle actin, green) during the process of vascular maturation. See the article by Scheppke et al on page 2149.

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