Issue Archive

The image shows the increased collagen deposition surrounding the bronchioles of the lungs in mice with chronic GVHD (cGVHD). Mice transplanted with full MHC disparate bone marrow and mature T cells develop extensive fibrosis and inflammation in target organs, such as the lung, compared to mice that receive MHC disparate bone marrow alone. The increase in lung damage, caused by pathogenic antibody deposition, leads to the development of bronchiolitis obliterans, a pathognomonic feature of cGVHD. See the article by Srinivasan et al on page 1570.