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Inside Blood

INSIDE BLOOD
MYELOID NEOPLASIA
MYELOID NEOPLASIA
THROMBOSIS & HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
VASCULAR BIOLOGY

Blood Work

Review Article

Clinical Trials and Observations

Gene Therapy

Hematopoiesis and Stem Cells

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transplantation

Vascular Biology

Correspondence

  • Cover Image

    Cover Image

    issue cover

    The hypoxic environment at high altitude stimulates erythropoiesis (top bubble). Flow cytometry was used to analyze the consequent response of erythroid precursors in vivo within the spleen and bone marrow erythroblastic island niche (middle bubbles). Two regulators of the mitochondrial apoptotic pathway, Bcl-xL and Bim, had markedly different dynamic responses to erythropoietin receptor activation (EpoR, lowest bubble). The proapoptotic Bim was suppressed for the duration of stress. By contrast, the antiapoptotic Bcl-xL and its upstream regulator, Stat5, showed classical adaptation, similar to that of sensory systems or bacterial chemotaxis. Adaptation extends the dynamic range of the stress response. Illustration by Miroslav Koulnis. For details, see the article by Koulnis et al on page 1228.

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