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Inside Blood

HEMATOPOIESIS & STEM CELLS
HEMATOPOIESIS & STEM CELLS
INSIDE BLOOD
INSIDE BLOOD
MYELOID NEOPLASIA
PLATELETS & THROMBOPOIESIS
TRANSPLANTATION

Blood Work

Plenary Paper

PLENARY PAPER

Perspectives

Review Article

How I treat

Blood Consult

Clinical Trials and Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transplantation

Vascular Biology

  • Cover Image

    Cover Image

    issue cover

    Apoptotic Tango: megakaryopoiesis in mice with a megakaryocyte-specific deletion of Mcl-1 (Mcl-1Pf4Δ/Pf4Δ) is normal. However, 2.5 hours after treatment with the BH3 mimetic ABT-737, megakaryocytes from these mice exhibit hallmarks of apoptosis with nuclear pyknosis and cytoplasmic dysmorphology evident. The image shows two megakaryocytes undergoing “a dance of death” in the bone marrow of Mcl-1Pf4Δ/Pf4Δ mice, indicating essential roles for both Bcl-xL and Mcl-1 in the viability of the megakaryocyte lineage. See the article by Debrincat et al on page 5850.

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