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Inside Blood

CLINICAL TRIALS
CLINICAL TRIALS
GENE THERAPY
IMMUNOBIOLOGY
PHAGOCYTES & GRANULOCYTES
PLATELETS & THROMBOPOIESIS

Blood Work

Plenary Paper

IMMUNOBIOLOGY

Perspectives

Review Article

Clinical Trials and Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transplantation

Errata

Other Departments

  • Cover Image

    Cover Image

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    A schematic representation elucidating the cycling pathway for glucose-6-phosphate (G6P) metabolism in macrophages. G6P participates in 4 major pathways: glycolysis, the hexose monophosphate shunt (HMS), glycogen synthesis, or endoplasmic reticulum (ER) cycling. In cycling, G6P enters the ER via glucose-6-phosphate transporter (G6PT) where it can accumulate until it is hydrolyzed to glucose by G6Pase-β and transported back into the cytoplasm. By limiting the cytoplasmic glucose/G6P availability, cycling regulates the other 3 cytoplasmic pathways for G6P metabolism. Disruption of this cycling in G6Pase-β–deficient macrophages results in impaired energy homeostasis and functionality. See the article by Jun et al on page 4047.

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