Skip to Main Content

Advertisement

Issue Archive

Table of Contents

Inside Blood

IMMUNOBIOLOGY
CLINICAL TRIALS
GENE THERAPY
INSIDE BLOOD
MYELOID NEOPLASIA
THROMBOSIS & HEMOSTASIS

Blood Work

Plenary Paper

PLENARY PAPER

Review Articles

How I Treat

Clinical Trials and Observations

Gene Therapy

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Thrombosis and Hemostasis

Transplantation

Correspondence

  • Cover Image

    Cover Image

    issue cover

    The figure illustrates, in a schematic manner, the complexity of small RNAs that can be produced by canonical and noncanonical processing (“the scissors”) of hairpin precursors in a model of myeloproliferative disease. This complexity has been dissected by Illumina sequencing of the small RNA fraction from the JAK2V617F-mutated SET2 cell line. In addition to variably expressed known mature miRNAs (5′ and 3′ miRs, dark and light green rectangles), several “novel miRNAs” expressed from known hairpin precursors were identified. Furthermore, an unexpectedly high number of additional short RNAs were discovered: “isomiRs,” ie, sequence variants produced mainly by noncanonical processing of hairpin precursors; and “moRNAs” (5′ and 3′ moRs, dark and light blue), ie, micro-RNA offset RNAs, approximately 20-nt long RNAs that originate predominantly from the 5′ arm of pre-miRNAs with a biogenesis linked to that of miRNAs but not necessarily interdependent. A fraction of moRNAs have been reported to localize to the nucleus (purple area), unlike mature miRNAs that have a cytoplasmic distribution (black area). See the online article by Bortoluzzi et al on page e120.

  • PDF Icon PDF LinkFront Matter
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkBack Matter
  • PDF Icon PDF LinkAdvertising
  • PDF Icon PDF LinkEditorial Board
Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal

Advertisement