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Inside Blood

HEMATOPOIESIS & STEM CELLS
IMMUNOBIOLOGY
IMMUNOBIOLOGY
THROMBOSIS & HEMOSTASIS
TRANSPLANTATION
TRANSPLANTATION
VASCULAR BIOLOGY

Blood Work

Review Articles

How I Treat

Clinical Trials and Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transplantation

Vascular Biology

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    Cover Image

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    Asymmetric cell division as a mechanism for hematopoietic stem cell (HSC) self-renewal remains enigmatic. The endocytic gene, Ap2a2, is shown to impact upon HSC self-renewal while also demonstrating asymmetric segregation during real-time videomicroscopy. In these still images taken from a videomicroscopy of a CD150+48 LSK stem cell transduced with a cherry-Ap2a2 fluorescent fusion, Ap2a2 is seen to clearly localize at one polar side during telophase, and then asymmetrically segregate into only one daughter cell after cytokinesis. See Figure 7 and supplemental videos in the article by Ting et al on page 2510.

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