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Issue Archive

Volume 118, Issue 9
September 1 2011
Blood Cover Image for Volume 118, Issue 9

Table of Contents

Inside Blood

HEMATOPOIESIS & STEM CELLS
A stressed niche not Wnted
Emma K. Baker,Louise E. Purton
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CLINICAL TRIALS
RIC alloSCT in MM: a long way to go
Philippe Moreau
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HEMATOPOIESIS & STEM CELLS
Stress hematopoiesis requires Erg
Stefan Karlsson
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IMMUNOBIOLOGY
Medullary interplay for central tolerance
Yousuke Takahama
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IMMUNOBIOLOGY
Buzz in the dendritic cell synapse
Lisa Westerberg
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THROMBOSIS & HEMOSTASIS
Clots vs bugs: who's ahead?
Russell F. Doolittle
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TRANSFUSION MEDICINE
FISHing for aneuploidy in HSCT donors
Matthew J. Olnes
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TRANSPLANTATION
Back to the OR?
Andrea Bacigalupo
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Blood Work

Metastatic neuroendocrine cells
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Perspectives

Applicability of a “Pick a Winner” trial design to acute myeloid leukemia
Clinical Trials & Observations
Robert K. Hills,Alan K. Burnett
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Review Article

Blood doping and its detection
Wolfgang Jelkmann,Carsten Lundby
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Hematopoiesis and Stem Cells

Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
Christoph Schaniel,Dario Sirabella,Jiajing Qiu,Xiaohong Niu,Ihor R. Lemischka,Kateri A. Moore
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Supplemental data
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay
Kajal Biswas,Ranabir Das,Blanche P. Alter,Sergey G. Kuznetsov,Stacey Stauffer,Susan L. North,Sandra Burkett,Lawrence C. Brody,Stefan Meyer,R. Andrew Byrd,Shyam K. Sharan
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Supplemental data
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice
Ashley P. Ng,Stephen J. Loughran,Donald Metcalf,Craig D. Hyland,Carolyn A. de Graaf,Yifang Hu,Gordon K. Smyth,Douglas J. Hilton,Benjamin T. Kile,Warren S. Alexander
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Supplemental data

Immunobiology

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
François-Xavier Hubert,Sarah A. Kinkel,Gayle M. Davey,Belinda Phipson,Scott N. Mueller,Adrian Liston,Anna I. Proietto,Ping Z. F. Cannon,Simon Forehan,Gordon K. Smyth,Li Wu,Christopher C. Goodnow,Francis R. Carbone,Hamish S. Scott,William R. Heath
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Supplemental data
Inflammation restraining effects of prostaglandin E2 on natural killer–dendritic cell (NK-DC) interaction are imprinted during DC maturation
Catharina H. M. J. Van Elssen,Joris Vanderlocht,Tammy Oth,Birgit L. M. G. Senden-Gijsbers,Wilfred T. V. Germeraad,Gerard M. J. Bos
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Supplemental data
Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes
Gildas Belrose,Antoine Gross,Stéphane Olindo,Agnès Lézin,Maryvonne Dueymes,Isabelle Komla-Soukha,Didier Smadja,Yuetsu Tanaka,Luc Willems,Jean-Michel Mesnard,Jean-Marie Peloponese, Jr,Raymond Césaire
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Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming
Gerben Bouma,Ariadna Mendoza-Naranjo,Michael P. Blundell,Elena de Falco,Kathryn L. Parsley,Siobhan O. Burns,Adrian J. Thrasher
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Supplemental data
Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
Rieneke van de Ven,Mari F. C. M. van den Hout,Jelle J. Lindenberg,Berbel J. R. Sluijter,Paul A. M. van Leeuwen,Sinéad M. Lougheed,Sybren Meijer,M. Petrousjka van den Tol,Rik J. Scheper,Tanja D. de Gruijl
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Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis
Jianjun Shi,Mohammad Fallahi,Jun-Li Luo,Howard T. Petrie
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IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques
Enrico Lugli,Yvonne M. Mueller,Mark G. Lewis,Francois Villinger,Peter D. Katsikis,Mario Roederer
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Supplemental data

Lymphoid Neoplasia

Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial
Clinical Trials & Observations
Evelien Kneppers,Bronno van der Holt,Marie-Jose Kersten,Sonja Zweegman,Ellen Meijer,Gerwin Huls,Jan J. Cornelissen,Jeroen J. Janssen,Cynthia Huisman,Petra B. Cornelisse,Cheryl P. Bruijnen,Maarten Emmelot,Pieter Sonneveld,Henk M. Lokhorst,Tuna Mutis,Monique C. Minnema
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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
Sean H. Lim,Andrew T. Vaughan,Margaret Ashton-Key,Emily L. Williams,Sandra V. Dixon,H. T. Claude Chan,Stephen A. Beers,Ruth R. French,Kerry L. Cox,Andrew J. Davies,Kathleen N. Potter,C. Ian Mockridge,David G. Oscier,Peter W. M. Johnson,Mark S. Cragg,Martin J. Glennie
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Supplemental data

Myeloid Neoplasia

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF
Nahoko Nishimoto,Shunya Arai,Motoshi Ichikawa,Masahiro Nakagawa,Susumu Goyama,Keiki Kumano,Tsuyoshi Takahashi,Yasuhiko Kamikubo,Yoichi Imai,Mineo Kurokawa
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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
Brief Report
Elodie Pronier,Carole Almire,Hayat Mokrani,Aparna Vasanthakumar,Audrey Simon,Barbara da Costa Reis Monte Mor,Aline Massé,Jean-Pierre Le Couédic,Frédéric Pendino,Bruno Carbonne,Jérôme Larghero,Jean-Luc Ravanat,Nicole Casadevall,Olivier A. Bernard,Nathalie Droin,Eric Solary,Lucy A. Godley,William Vainchenker,Isabelle Plo,François Delhommeau
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Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

p16INK4a deficiency promotes IL-4–induced polarization and inhibits proinflammatory signaling in macrophages
Céline Cudejko,Kristiaan Wouters,Lucía Fuentes,Sarah Anissa Hannou,Charlotte Paquet,Kadiombo Bantubungi,Emmanuel Bouchaert,Jonathan Vanhoutte,Sébastien Fleury,Patrick Remy,Anne Tailleux,Giulia Chinetti-Gbaguidi,David Dombrowicz,Bart Staels,Réjane Paumelle
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Supplemental data
Structural variants of IFNα preferentially promote antiviral functions
Nancy Vázquez,Hana Schmeisser,Michael A. Dolan,Joseph Bekisz,Kathryn C. Zoon,Sharon M. Wahl
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Red Cells, Iron, and Erythropoiesis

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis
Yuta Mishima,Satoru Miyagi,Atsunori Saraya,Masamitsu Negishi,Mitsuhiro Endoh,Takaho A. Endo,Tetsuro Toyoda,Jun Shinga,Takuo Katsumoto,Tetsuhiro Chiba,Naoto Yamaguchi,Issay Kitabayashi,Haruhiko Koseki,Atsushi Iwama
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Supplemental data
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis
Sten F. Libregts,Laura Gutiérrez,Alexander M. de Bruin,Felix M. Wensveen,Petros Papadopoulos,Wilfred van Ijcken,Zeliha Özgür,Sjaak Philipsen,Martijn A. Nolte
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Supplemental data

Thrombosis and Hemostasis

Thrombogenicity and cardiovascular effects of ambient air pollution
Massimo Franchini,Pier Mannuccio Mannucci
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Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense
Torsten G. Loof,Matthias Mörgelin,Linda Johansson,Sonja Oehmcke,Anders I. Olin,Gerhard Dickneite,Anna Norrby-Teglund,Ulrich Theopold,Heiko Herwald
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Supplemental data
JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients
Brief Report
Marina Panova-Noeva,Marina Marchetti,Sabrina Buoro,Laura Russo,Annamaria Leuzzi,Guido Finazzi,Alessandro Rambaldi,Cosimo Ottomano,Hugo ten Cate,Anna Falanga
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Transfusion Medicine

Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors
Clinical Trials & Observations
Betsy Hirsch,LeAnn Oseth,Meghan Cain,Erin Trader,Shelley Pulkrabek,Bruce Lindgren,Xianghua Luo,Mary Clay,John Miller,Dennis Confer,Daniel Weisdorf,Jeffrey McCullough
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Transplantation

Reduced-intensity conditioning therapy with busulfan, fludarabine, and antithymocyte globulin for HLA-haploidentical hematopoietic cell transplantation in acute leukemia and myelodysplastic syndrome
Clinical Trials & Observations
Kyoo-Hyung Lee,Je-Hwan Lee,Jung-Hee Lee,Dae-Young Kim,Miee Seol,Young-Shin Lee,Young-Ah Kang,Mijin Jeon,Hyun-Ju Hwang,Ah-Rang Jung,Sung-Han Kim,Sung-Cheol Yun,Ho-Jin Shin
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Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia
Brief Report
Mary Eapen,Jennifer Le Rademacher,Joseph H. Antin,Richard E. Champlin,Jeanette Carreras,Joseph Fay,Jakob R. Passweg,Jakub Tolar,Mary M. Horowitz,Judith C. W. Marsh,H. Joachim Deeg
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Supplemental data

Vascular Biology

Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1–mediated transcriptional events
Jai-Hyun Kim,Dong Soon Choi,Ok-Hee Lee,Seung-Hyun Oh,Scott M. Lippman,Ho-Young Lee
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Supplemental data

Correspondence

Polymorphism in the PAI-1 (SERPINE1) gene and the risk of osteonecrosis in children with acute lymphoblastic leukemia
Jonathan Bond,Stuart Adams,Susan Richards,Ajay Vora,Christopher Mitchell,Nicholas Goulden
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Confocal imaging studies cast doubt on nuclear localization of JAK2V617F
François Girodon,Mara P. Steinkamp,Cédric Cleyrat,Sylvie Hermouet,Bridget S. Wilson
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Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C
Prosenjit Sen,Ramesh Nayak,Curtis A. Clark,Ramakrishnan Gopalakrishnan,Charles T. Esmon,Usha R. Pendurthi,L. Vijaya Mohan Rao
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Linking air pollution exposure with thrombosis
Gökhan M. Mutlu,Paul J. Bryce,G. R. Scott Budinger
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Prediction of fetal status in fetal/neonatal alloimmune thrombocytopenia (FNAIT)?
Ulrich J. Sachs,Tamam Bakchoul,Volker Kiefel,Sentot Santoso
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The pathophysiology of FNAIT cannot be deduced from highly selected retrospective data
Jens Kjeldsen-Kragh,Anne Husebekk,Mette Kjær Killie,Bjørn Skogen
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Response: prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia
Gerald Bertrand,Moustapha Drame,Corinne Martageix,Cecile Kaplan
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All Issues

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