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Issue Archive

Volume 118, Issue 26
December 22 2011
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Enigmatic variation
Irene Roberts,Paresh Vyas
View Articletitled, Enigmatic variation
IMMUNOBIOLOGY
Predicting cytokine storms: it's about density
Matthew J. Frigault,Carl H. June
View Articletitled, Predicting cytokine storms: it's about density
IMMUNOBIOLOGY
Antibody co-targeting of DCs
Laurence Zitvogel,Karolina Palucka
View Articletitled, Antibody co-targeting of DCs
MYELOID NEOPLASIA
The antileukemic activity of Δ12-PGJ3
Paul A. Ney
View Articletitled, The antileukemic activity of Δ<sup>12</sup>-PGJ<sub>3</sub>
PHAGOCYTES & GRANULOCYTES
Deleting Mcl-1 in mast cells: getting 2 birds with 1 stone
Booki Min
View Articletitled, Deleting Mcl-1 in mast cells: getting 2 birds with 1 stone
THROMBOSIS & HEMOSTASIS
A cofactor for factor XI activation
David Gailani
View Articletitled, A cofactor for factor XI activation
TRANSPLANTATION
TCR-MHC-peptide(s): in vivo veritas
Paul J. Martin
View Articletitled, TCR-MHC-peptide(s): in vivo veritas

Plenary Paper

TRANSPLANTATION
Allo-HLA–reactive T cells inducing graft-versus-host disease are single peptide specific
Avital L. Amir,Dirk M. van der Steen,Renate S. Hagedoorn,Michel G. D. Kester,Cornelis A. M. van Bergen,Jan W. Drijfhout,Arnoud H. de Ru,J. H. Frederik Falkenburg,Peter A. van Veelen,Mirjam H. M. Heemskerk
View Articletitled, Allo-HLA–reactive T cells inducing graft-versus-host disease are single peptide specific

Review Article

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
Alexander Zarbock,Klaus Ley,Rodger P. McEver,Andrés Hidalgo
View Articletitled, Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

Clinical Trials and Observations

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971
CME
Alan S. Gamis,Todd A. Alonzo,Robert B. Gerbing,Joanne M. Hilden,April D. Sorrell,Mukta Sharma,Thomas W. Loew,Robert J. Arceci,Dorothy Barnard,John Doyle,Gita Massey,John Perentesis,Yaddanapudi Ravindranath,Jeffrey Taub,Franklin O. Smith
View Articletitled, Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971
Supplemental data
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV
Clinical Trials & Observations
Alice Fabarius,Armin Leitner,Andreas Hochhaus,Martin C. Müller,Benjamin Hanfstein,Claudia Haferlach,Gudrun Göhring,Brigitte Schlegelberger,Martine Jotterand,Andreas Reiter,Susanne Jung-Munkwitz,Ulrike Proetel,Juliana Schwaab,Wolf-Karsten Hofmann,Jörg Schubert,Hermann Einsele,Anthony D. Ho,Christiane Falge,Lothar Kanz,Andreas Neubauer,Michael Kneba,Frank Stegelmann,Michael Pfreundschuh,Cornelius F. Waller,Karsten Spiekermann,Gabriela M. Baerlocher,Michael Lauseker,Markus Pfirrmann,Joerg Hasford,Susanne Saussele,Rüdiger Hehlmann,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group
View Articletitled, Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
Brief Report
Davide Rossi,Alessio Bruscaggin,Valeria Spina,Silvia Rasi,Hossein Khiabanian,Monica Messina,Marco Fangazio,Tiziana Vaisitti,Sara Monti,Sabina Chiaretti,Anna Guarini,Ilaria Del Giudice,Michaela Cerri,Stefania Cresta,Clara Deambrogi,Ernesto Gargiulo,Valter Gattei,Francesco Forconi,Francesco Bertoni,Silvia Deaglio,Raul Rabadan,Laura Pasqualucci,Robin Foà,Riccardo Dalla-Favera,Gianluca Gaidano
View Articletitled, Mutations of the <em>SF3B1</em> splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
Supplemental data
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
Clinical Trials & Observations
Klaus H. Metzeler,Heiko Becker,Kati Maharry,Michael D. Radmacher,Jessica Kohlschmidt,Krzysztof Mrózek,Deedra Nicolet,Susan P. Whitman,Yue-Zhong Wu,Sebastian Schwind,Bayard L. Powell,Thomas H. Carter,Meir Wetzler,Joseph O. Moore,Jonathan E. Kolitz,Maria R. Baer,Andrew J. Carroll,Richard A. Larson,Michael A. Caligiuri,Guido Marcucci,Clara D. Bloomfield
View Articletitled, <em>ASXL1</em> mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
Supplemental data

Hematopoiesis and Stem Cells

Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis
Brief Report
Masaki Yoda,Tokuhiro Kimura,Takahide Tohmonda,Shinichi Uchikawa,Takeshi Koba,Jiro Takito,Hideo Morioka,Morio Matsumoto,Daniel C. Link,Kazuhiro Chiba,Yasunori Okada,Yoshiaki Toyama,Keisuke Horiuchi
View Articletitled, Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis
Supplemental data

Immunobiology

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
Paula S. Römer,Susanne Berr,Elita Avota,Shin-Young Na,Manuela Battaglia,Ineke ten Berge,Hermann Einsele,Thomas Hünig
View Articletitled, Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
Supplemental data
Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells
Jérome Carlier,Hélène Martin,Bernard Mariamé,Benjamin Rauwel,Catherine Mengelle,Hugo Weclawiak,Alain Coaquette,Charline Vauchy,Pierre Rohrlich,Nassim Kamar,Lionel Rostaing,Georges Herbein,Christian Davrinche
View Articletitled, Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells
Supplemental data
MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
Yong Huang,YingFeng Lei,Hai Zhang,LiChao Hou,Mingjie Zhang,Andrew I. Dayton
View Articletitled, MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
Supplemental data
B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency
Gertjan J. Driessen,Menno C. van Zelm,P. Martin van Hagen,Nico G. Hartwig,Margreet Trip,Adilia Warris,Esther de Vries,Barbara H. Barendregt,Ingrid Pico,Wim Hop,Jacques J. M. van Dongen,Mirjam van der Burg
View Articletitled, B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency
Supplemental data
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo
Mike Recher,Lucinda J. Berglund,Danielle T. Avery,Morton J. Cowan,Andrew R. Gennery,Joanne Smart,Jane Peake,Melanie Wong,Sung-Yun Pai,Sachin Baxi,Jolan E. Walter,Umaimainthan Palendira,Gillian A. Tangye,Michael Rice,Shannon Brothers,Waleed Al-Herz,Hans Oettgen,Hermann Eibel,Jennifer M. Puck,Federica Cattaneo,John B. Ziegler,Silvia Giliani,Stuart G. Tangye,Luigi D. Notarangelo
View Articletitled, IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo
Supplemental data
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
Paul J. Tacken,Ingrid S. Zeelenberg,Luis J. Cruz,Maaike A. van Hout-Kuijer,Gerline van de Glind,Remco G. Fokkink,Annechien J. A. Lambeck,Carl G. Figdor
View Articletitled, Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
Supplemental data
IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood
Brief Report
Michael C. Sneller,William C. Kopp,Kory J. Engelke,Jason L. Yovandich,Stephen P. Creekmore,Thomas A. Waldmann,H. Clifford Lane
View Articletitled, IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8<sup>+</sup> T effector memory population in peripheral blood
Transcriptomic analyses of murine resolution-phase macrophages
e-blood
Melanie J. Stables,Sonia Shah,Evelyn B. Camon,Ruth C. Lovering,Justine Newson,Jonas Bystrom,Stuart Farrow,Derek W. Gilroy
View Articletitled, Transcriptomic analyses of murine resolution-phase macrophages
Supplemental data

Lymphoid Neoplasia

Rituximab blocks protective serologic response to influenza A (H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment
Brief Report
Olav Erich Yri,Dag Torfoss,Olav Hungnes,Anne Tierens,Kristian Waalen,Tone Nordøy,Susanne Dudman,Anette Kilander,Karin Fahl Wader,Bjørn Østenstad,Roald Ekanger,Peter Meyer,Arne Kolstad
View Articletitled, Rituximab blocks protective serologic response to influenza A (H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment
A shared gene expression signature in mouse models of EBV-associated and non–EBV-associated Burkitt lymphoma
Kathryn T. Bieging,Kamonwan Fish,Subbarao Bondada,Richard Longnecker
View Articletitled, A shared gene expression signature in mouse models of EBV-associated and non–EBV-associated Burkitt lymphoma
Supplemental data
Defining the role of TORC1/2 in multiple myeloma
Patricia Maiso,Yi Liu,Brittany Morgan,Abdel Kareem Azab,Pingda Ren,Michel B. Martin,Yong Zhang,Yang Liu,Antonio Sacco,Hai Ngo,Feda Azab,Phong Quang,Scott J. Rodig,Charles P. Lin,Aldo M. Roccaro,Christian Rommel,Irene M. Ghobrial
View Articletitled, Defining the role of TORC1/2 in multiple myeloma
Supplemental data
Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
Sonia D'Souza,Davide del Prete,Shunqian Jin,Quanhong Sun,Alissa J. Huston,Flavia Esteve Kostov,Benedicte Sammut,Chang-Sook Hong,Judith L. Anderson,Kenneth D. Patrene,Shibing Yu,Chinavenmeni S. Velu,Guozhi Xiao,H. Leighton Grimes,G. David Roodman,Deborah L. Galson
View Articletitled, Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
Supplemental data
miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma
Hironori Matsuyama,Hiroshi I. Suzuki,Hikaru Nishimori,Masaaki Noguchi,Takashi Yao,Norio Komatsu,Hiroyuki Mano,Koichi Sugimoto,Kohei Miyazono
View Articletitled, miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma
Supplemental data
FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death
Lapo Alinari,Emilia Mahoney,John Patton,Xiaoli Zhang,Lenguyen Huynh,Christian T. Earl,Rajeswaran Mani,Yicheng Mao,Bo Yu,Carl Quinion,William H. Towns,Ching-Shih Chen,David M. Goldenberg,Kristie A. Blum,John C. Byrd,Natarajan Muthusamy,Mette Prætorius-Ibba,Robert A. Baiocchi
View Articletitled, FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death
Supplemental data

Myeloid Neoplasia

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
Daniel Smrž,Mi-Sun Kim,Shuling Zhang,Beverly A. Mock,Šárka Smržová,Wendy DuBois,Olga Simakova,Irina Maric,Todd M. Wilson,Dean D. Metcalfe,Alasdair M. Gilfillan
View Articletitled, mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
Supplemental data
Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde,Naveen Kaushal,Kodihalli C. Ravindra,Christopher Chiaro,Kelsey T. Hafer,Ujjawal H. Gandhi,Jerry T. Thompson,John P. van den Heuvel,Mary J. Kennett,Pamela Hankey,Robert F. Paulson,K. Sandeep Prabhu
View Articletitled, Δ<sup>12</sup>-prostaglandin J<sub>3</sub>, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
Jennifer N. Lilla,Ching-Cheng Chen,Kaori Mukai,Maya J. BenBarak,Christopher B. Franco,Janet Kalesnikoff,Mang Yu,Mindy Tsai,Adrian M. Piliponsky,Stephen J. Galli
View Articletitled, Reduced mast cell and basophil numbers and function in <em>Cpa3-Cre</em>; <em>Mcl-1</em><sup>fl/fl</sup> mice
Supplemental data

Red Cells, Iron, and Erythropoiesis

Ribosomal protein gene deletions in Diamond-Blackfan anemia
Jason E. Farrar,Adrianna Vlachos,Eva Atsidaftos,Hannah Carlson-Donohoe,Thomas C. Markello,Robert J. Arceci,Steven R. Ellis,Jeffrey M. Lipton,David M. Bodine
View Articletitled, Ribosomal protein gene deletions in Diamond-Blackfan anemia
Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell–invasive merozoites
Giulia Costa,Séverine Loizon,Marianne Guenot,Iulia Mocan,Franck Halary,Geneviève de Saint-Basile,Vincent Pitard,Julie Déchanet-Merville,Jean-François Moreau,Marita Troye-Blomberg,Odile Mercereau-Puijalon,Charlotte Behr
View Articletitled, Control of <em>Plasmodium falciparum</em> erythrocytic cycle: γδ T cells target the red blood cell–invasive merozoites
Supplemental data

Thrombosis and Hemostasis

Polyphosphate is a cofactor for the activation of factor XI by thrombin
Sharon H. Choi,Stephanie A. Smith,James H. Morrissey
View Articletitled, Polyphosphate is a cofactor for the activation of factor XI by thrombin

Transplantation

Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase
Karin Landfried,Wentao Zhu,Magdalena C. Waldhier,Ute Schulz,Julia Ammer,Barbara Holler,Daniel Wolff,Matthias Edinger,Katrin Peter,Marina Kreutz,Reinhard Andreesen,Peter J. Oefner,Ernst Holler
View Articletitled, Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase

Vascular Biology

Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm
Hiroshi Kataoka,Misato Hayashi,Reiko Nakagawa,Yosuke Tanaka,Naoki Izumi,Satomi Nishikawa,Martin Lars Jakt,Hiroshi Tarui,Shin-Ichi Nishikawa
View Articletitled, Etv2/ER71 induces vascular mesoderm from Flk1<sup>+</sup>PDGFRα<sup>+</sup> primitive mesoderm
Supplemental data

Correspondence

Nuclear JAK2
Mark A. Dawson,Andrew J. Bannister,Lindsay Saunders,Omar-Abdel Wahab,Fan Liu,Stephen D. Nimer,Ross L. Levine,Berthold Göttgens,Tony Kouzarides,Anthony R. Green
View Articletitled, Nuclear JAK2
A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia
Bing Zhang,Dana Ng,Carol Jones,Stephen T. Oh,Garry P. Nolan,Shiva Salehi,Wendy Wong,James L. Zehnder,Jason Gotlib
View Articletitled, A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia
Increased coagulation factor VIII activity in patients with familial hypercholesterolemia
Roeland Huijgen,John J. P. Kastelein,Joost C. M. Meijers
View Articletitled, Increased coagulation factor VIII activity in patients with familial hypercholesterolemia

Errata

Harman AN, Lai J, Turville S, et al. HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Blood. 2011;118(2):298-308.
View Articletitled, Harman AN, Lai J, Turville S, et al. HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. <em>Blood</em>. 2011;118(2):<span class="related-article">298-308</span>.
Arora M, Klein JP, Weisdorf DJ, et al. Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis. Blood. 2011;117(24):6714-6720.
View Articletitled, Arora M, Klein JP, Weisdorf DJ, et al. Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis. <em>Blood</em>. 2011;117(24):<span class="related-article">6714-6720</span>.
Fraser SR, Booth NA, Mutch NJ. The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking. Blood. 2011;117(23):6371-6374.
View Articletitled, Fraser SR, Booth NA, Mutch NJ. The antifibrinolytic function of factor XIII is exclusively expressed through α<sub>2</sub>-antiplasmin cross-linking. <em>Blood</em>. 2011;117(23):<span class="related-article">6371-6374</span>.
Montserrat E, Gribben JG. Autografting CLL: the game is over! Blood. 2011;117(23):6057-6058.
View Articletitled, Montserrat E, Gribben JG. Autografting CLL: the game is over! <em>Blood</em>. 2011;117(23):<span class="related-article">6057-6058</span>.
Merryweather-Clarke AT, Atzberger A, Soneji S, et al. Global gene expression analysis of human erythroid progenitors. Blood. 2011;117(13):e96-e108.
View Articletitled, Merryweather-Clarke AT, Atzberger A, Soneji S, et al. Global gene expression analysis of human erythroid progenitors. <em>Blood</em>. 2011;117(13):<span class="related-article">e96-e108</span>.
Sehrawat S, Ernandez T, Cullere X, et al. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. Blood. 2011;117(2):708-718.
View Articletitled, Sehrawat S, Ernandez T, Cullere X, et al. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. <em>Blood</em>. 2011;117(2):<span class="related-article">708-718</span>.
Allen A, Fisher C, Premawardhena A, et al. Adaptation to anemia in hemoglobin E-β thalassemia. Blood. 2010;116(24):5368-5370.
View Articletitled, Allen A, Fisher C, Premawardhena A, et al. Adaptation to anemia in hemoglobin E-β thalassemia. <em>Blood</em>. 2010;116(24):<span class="related-article">5368-5370</span>.
Premawardhena A, Fisher CA, De Silva S, et al. A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology. Blood. 2005;106(9):3251-3255.
View Articletitled, Premawardhena A, Fisher CA, De Silva S, et al. A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology. <em>Blood</em>. 2005;106(9):<span class="related-article">3251-3255</span>.

Other Departments

Continuing Medical Education (CME) questions: transient myeloproliferative disorder natural history
CME
View Articletitled, Continuing Medical Education (CME) questions: transient myeloproliferative disorder natural history
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