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Issue Archive

Volume 118, Issue 24
December 8 2011
Blood Cover Image for Volume 118, Issue 24

Table of Contents

Inside Blood

CLINICAL TRIALS
From the observation DAC: romidepsin revisited
Stefan Knop
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CLINICAL TRIALS
ITP: Tolerance Lost
Patrick F. Fogarty
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INSIDE BLOOD
Innovation in myeloma treatments PARP excellence!
Rafael Fonseca
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MYELOID NEOPLASIA
Getting to know JAK
Hal E. Broxmeyer
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MYELOID NEOPLASIA
It dices, it splices!
Virginia M. Klimek
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Plenary Paper

MYELOID NEOPLASIA
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Luca Malcovati,Elli Papaemmanuil,David T. Bowen,Jacqueline Boultwood,Matteo G. Della Porta,Cristiana Pascutto,Erica Travaglino,Michael J. Groves,Anna L. Godfrey,Ilaria Ambaglio,Anna Gallì,Matteo C. Da Vià,Simona Conte,Sudhir Tauro,Norene Keenan,Ann Hyslop,Jonathan Hinton,Laura J. Mudie,James S. Wainscoat,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Eva Hellström-Lindberg,Mario Cazzola,on behalf of the Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium and of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative
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Supplemental data

Review Articles

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
Sheryl M. Gough,Christopher I. Slape,Peter D. Aplan
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Evidence-Based Focused Review

Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility
Clinical Trials & Observations
Renato D. Lopes,John D. Horowitz,David A. Garcia,Mark A. Crowther,Elaine M. Hylek
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Clinical Trials and Observations

Safety of long-term treatment of HAM/TSP patients with valproic acid
Brief Report
Stéphane Olindo,Gildas Belrose,Nicolas Gillet,Sabrina Rodriguez,Mathieu Boxus,Olivier Verlaeten,Becca Asquith,Charles Bangham,Aïssatou Signaté,Didier Smadja,Agnès Lezin,Raymond Césaire,Luc Willems
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Hematopoiesis and Stem Cells

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
Dominique Bluteau,Laure Gilles,Morgane Hilpert,Iléana Antony-Debré,Chloe James,Najet Debili,Valerie Camara-Clayette,Orianne Wagner-Ballon,Veronique Cordette-Lagarde,Thomas Robert,Hugues Ripoche,Patrick Gonin,Sabina Swierczek,Josef Prchal,William Vainchenker,Remi Favier,Hana Raslova
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Immunobiology

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling
Franziska Hampel,Stefanie Ehrenberg,Caroline Hojer,Anne Draeseke,Gabriele Marschall-Schröter,Ralf Kühn,Brigitte Mack,Olivier Gires,Christoph J. Vahl,Marc Schmidt-Supprian,Lothar J. Strobl,Ursula Zimber-Strobl
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FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling
Hae Won Sohn,Peter D. Krueger,Randall S. Davis,Susan K. Pierce
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IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
Brief Report
Don M. Benson, Jr,Courtney E. Bakan,Shuhong Zhang,Shauna M. Collins,Jing Liang,Shivani Srivastava,Craig C. Hofmeister,Yvonne Efebera,Pascale Andre,Francois Romagne,Mathieu Bléry,Cécile Bonnafous,Jianying Zhang,David Clever,Michael A. Caligiuri,Sherif S. Farag
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Lymphoid Neoplasia

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma
Clinical Trials & Observations
Simon J. Harrison,Hang Quach,Emma Link,John F. Seymour,David S. Ritchie,Sam Ruell,Joanne Dean,Henry Januszewicz,Ricky Johnstone,Paul Neeson,Michael Dickinson,Jean Nichols,H. Miles Prince
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Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
Clinical Trials & Observations
Ebba K. Lindqvist,Lynn R. Goldin,Ola Landgren,Cecilie Blimark,Ulf-Henrik Mellqvist,Ingemar Turesson,Anders Wahlin,Magnus Björkholm,Sigurdur Y. Kristinsson
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Phase 2 study of PVAG (prednisone, vinblastine, doxorubicin, gemcitabine) in elderly patients with early unfavorable or advanced stage Hodgkin lymphoma
Clinical Trials & Observations
Boris Böll,Henning Bredenfeld,Helen Görgen,Teresa Halbsguth,Hans T. Eich,Martin Soekler,Jana Markova,Ulrich Keller,Ullrich Graeven,Stephan Kremers,Michael Geissler,Guido Trenn,Michael Fuchs,Bastian von Tresckow,Dennis A. Eichenauer,Peter Borchmann,Andreas Engert
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SYK inhibition and response prediction in diffuse large B-cell lymphoma
Shuhua Cheng,Greg Coffey,X. Hannah Zhang,Rita Shaknovich,Zibo Song,Pin Lu,Anjali Pandey,Ari M. Melnick,Uma Sinha,Y. Lynn Wang
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The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
Clinical Trials & Observations
Fortunato Morabito,Rosaria De Filippi,Luca Laurenti,Katja Zirlik,Anna Grazia Recchia,Massimo Gentile,Emanuela Morelli,Ernesto Vigna,Vincenzo Gigliotti,Rosa Calemma,Barbara Amoroso,Antonino Neri,Giovanna Cutrona,Manlio Ferrarini,Stefano Molica,Giovanni Del Poeta,Claudio Tripodo,Antonio Pinto
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Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
Clinical Trials & Observations
Andrea Kühnl,Nicola Gökbuget,Martin Kaiser,Cornelia Schlee,Andrea Stroux,Thomas Burmeister,Liliana H. Mochmann,Dieter Hoelzer,Wolf-Karsten Hofmann,Eckhard Thiel,Claudia D. Baldus
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Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors
Paola Neri,Li Ren,Kathy Gratton,Erin Stebner,Jordan Johnson,Alexander Klimowicz,Peter Duggan,Pierfrancesco Tassone,Adnan Mansoor,Douglas A. Stewart,Sagar Lonial,Lawrence H. Boise,Nizar J. Bahlis
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Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice
Priscilla N. Kelly,Stephanie Grabow,Alex R. D. Delbridge,Andreas Strasser,Jerry M. Adams
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Myeloid Neoplasia

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
Angela G. Fleischman,Karl J. Aichberger,Samuel B. Luty,Thomas G. Bumm,Curtis L. Petersen,Shirin Doratotaj,Kavin B. Vasudevan,Dorian H. LaTocha,Fei Yang,Richard D. Press,Marc M. Loriaux,Heike L. Pahl,Richard T. Silver,Anupriya Agarwal,Thomas O'Hare,Brian J. Druker,Grover C. Bagby,Michael W. Deininger
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Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
Brief Report
Eliza Vakana,Jessica K. Altman,Heather Glaser,Nicholas J. Donato,Leonidas C. Platanias
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Platelets and Thrombopoiesis

A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
Clinical Trials & Observations
Adam Cuker,Alasdair J. Coles,Herman Sullivan,Edward Fox,Mark Goldberg,Pedro Oyuela,Annie Purvis,Diana S. Beardsley,David H. Margolin
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Supplemental data
The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia
Brief Report
Andrew R. Crow,Sara J. Suppa,Xi Chen,Patrick J. Mott,Alan H. Lazarus
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Red Cells, Iron, and Erythropoiesis

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
Shilpa M. Hattangadi,Piu Wong,Lingbo Zhang,Johan Flygare,Harvey F. Lodish
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The ribosome-related protein, SBDS, is critical for normal erythropoiesis
Saswati Sen,Hanming Wang,Chi Lan Nghiem,Kim Zhou,Janice Yau,Chetankumar S. Tailor,Meredith S. Irwin,Yigal Dror
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Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice
Lara Krieg,Oren Milstein,Philippe Krebs,Yu Xia,Bruce Beutler,Xin Du
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Transplantation

Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation
Xiaojian Wang,Hongmei Li,Catherine Matte-Martone,Weiguo Cui,Ning Li,Hung Sheng Tan,Derry Roopenian,Warren D. Shlomchik
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Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions
Clinical Trials & Observations
Hongtao Liu,Elizabeth S. Rich,Lucy Godley,Olatoyosi Odenike,Loren Joseph,Susana Marino,Justin Kline,Vu Nguyen,John Cunningham,Richard A. Larson,Paula del Cerro,Linda Schroeder,Lisa Pape,Wendy Stock,Amittha Wickrema,Andrew S. Artz,Koen van Besien
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Circulating B-cell activating factor level predicts clinical response of chronic graft-versus-host disease to extracorporeal photopheresis
Brief Report
Robert Whittle,Peter C. Taylor
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Vascular Biology

TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow–derived proangiogenic cell differentiation, function, and neovascularization
Akm Khyrul Wara,ShiYin Foo,Kevin Croce,Xinghui Sun,Basak Icli,Yevgenia Tesmenitsky,Fehim Esen,Jung-Soo Lee,Malayannan Subramaniam,Thomas C. Spelsberg,Eli I. Lev,Dorit Leshem-Lev,Reena L. Pande,Mark A. Creager,Anthony Rosenzweig,Mark W. Feinberg
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Bone marrow–derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease
Brief Report
Akm Khyrul Wara,Kevin Croce,ShiYin Foo,Xinghui Sun,Basak Icli,Yevgenia Tesmenitsky,Fehim Esen,Anthony Rosenzweig,Mark W. Feinberg
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Correspondence

Effect of combined dexamethasone/lenalidomide therapy on NK cell–receptor levels in myeloma patients
Clive R. Carter,Sylvia Feyler,Natuley Smalle,Gina B. Scott,Christopher Parrish,Katherine Cullen,Charlotte Kallmeyer,Philip M. Wood,Gordon Cook
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Response: dexamethasone dose alters expression of NK activating receptors in vivo
Andy Hsu,Hang Quach,Tsin Tai,H. Miles Prince,Simon J. Harrison,Joseph A. Trapani,Mark J. Smyth,Paul J. Neeson,David S. Ritchie
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Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm
Mathias Vilaine,Damla Olcaydu,Ashot Harutyunyan,Jonathan Bergeman,Mourad Tiab,Jean-François Ramée,Jian-Min Chen,Robert Kralovics,Sylvie Hermouet
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Differential expression of MMP-2 and MMP-9 activity in megakaryocytes and platelets
Ferdinando Mannello,Virginia Medda
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Response: MMP-9 in platelets: maybe, maybe not
Emanuela Falcinelli,Loredana Bury,Neal Tolley,Marco Malvestiti,Luca Cecchetti,Andy Weyrich,Paolo Gresele
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Some observations on the geometry of megakaryocyte mitotic figures: Buckyballs in the bone marrow
John Anastasi
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All Issues

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