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IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma
Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
Phase 2 study of PVAG (prednisone, vinblastine, doxorubicin, gemcitabine) in elderly patients with early unfavorable or advanced stage Hodgkin lymphoma
The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions
Issue Archive
December 8 2011
In this Issue
Table of Contents
Inside Blood
Plenary Paper
MYELOID NEOPLASIA
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Luca Malcovati,Elli Papaemmanuil,David T. Bowen,Jacqueline Boultwood,Matteo G. Della Porta,Cristiana Pascutto,Erica Travaglino,Michael J. Groves,Anna L. Godfrey,Ilaria Ambaglio,Anna Gallì,Matteo C. Da Vià,Simona Conte,Sudhir Tauro,Norene Keenan,Ann Hyslop,Jonathan Hinton,Laura J. Mudie,James S. Wainscoat,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Eva Hellström-Lindberg,Mario Cazzola,on behalf of the Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium and of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative
Review Articles
Evidence-Based Focused Review
Clinical Trials and Observations
Hematopoiesis and Stem Cells
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
Dominique Bluteau,Laure Gilles,Morgane Hilpert,Iléana Antony-Debré,Chloe James,Najet Debili,Valerie Camara-Clayette,Orianne Wagner-Ballon,Veronique Cordette-Lagarde,Thomas Robert,Hugues Ripoche,Patrick Gonin,Sabina Swierczek,Josef Prchal,William Vainchenker,Remi Favier,Hana Raslova
Immunobiology
CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling
Franziska Hampel,Stefanie Ehrenberg,Caroline Hojer,Anne Draeseke,Gabriele Marschall-Schröter,Ralf Kühn,Brigitte Mack,Olivier Gires,Christoph J. Vahl,Marc Schmidt-Supprian,Lothar J. Strobl,Ursula Zimber-Strobl
IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
Brief Report
Don M. Benson, Jr,Courtney E. Bakan,Shuhong Zhang,Shauna M. Collins,Jing Liang,Shivani Srivastava,Craig C. Hofmeister,Yvonne Efebera,Pascale Andre,Francois Romagne,Mathieu Bléry,Cécile Bonnafous,Jianying Zhang,David Clever,Michael A. Caligiuri,Sherif S. Farag
Lymphoid Neoplasia
A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma
Clinical Trials & Observations
Simon J. Harrison,Hang Quach,Emma Link,John F. Seymour,David S. Ritchie,Sam Ruell,Joanne Dean,Henry Januszewicz,Ricky Johnstone,Paul Neeson,Michael Dickinson,Jean Nichols,H. Miles Prince
Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
Clinical Trials & Observations
Ebba K. Lindqvist,Lynn R. Goldin,Ola Landgren,Cecilie Blimark,Ulf-Henrik Mellqvist,Ingemar Turesson,Anders Wahlin,Magnus Björkholm,Sigurdur Y. Kristinsson
Phase 2 study of PVAG (prednisone, vinblastine, doxorubicin, gemcitabine) in elderly patients with early unfavorable or advanced stage Hodgkin lymphoma
Clinical Trials & Observations
Boris Böll,Henning Bredenfeld,Helen Görgen,Teresa Halbsguth,Hans T. Eich,Martin Soekler,Jana Markova,Ulrich Keller,Ullrich Graeven,Stephan Kremers,Michael Geissler,Guido Trenn,Michael Fuchs,Bastian von Tresckow,Dennis A. Eichenauer,Peter Borchmann,Andreas Engert
The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
Clinical Trials & Observations
Fortunato Morabito,Rosaria De Filippi,Luca Laurenti,Katja Zirlik,Anna Grazia Recchia,Massimo Gentile,Emanuela Morelli,Ernesto Vigna,Vincenzo Gigliotti,Rosa Calemma,Barbara Amoroso,Antonino Neri,Giovanna Cutrona,Manlio Ferrarini,Stefano Molica,Giovanni Del Poeta,Claudio Tripodo,Antonio Pinto
Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
Clinical Trials & Observations
Andrea Kühnl,Nicola Gökbuget,Martin Kaiser,Cornelia Schlee,Andrea Stroux,Thomas Burmeister,Liliana H. Mochmann,Dieter Hoelzer,Wolf-Karsten Hofmann,Eckhard Thiel,Claudia D. Baldus
Myeloid Neoplasia
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
Angela G. Fleischman,Karl J. Aichberger,Samuel B. Luty,Thomas G. Bumm,Curtis L. Petersen,Shirin Doratotaj,Kavin B. Vasudevan,Dorian H. LaTocha,Fei Yang,Richard D. Press,Marc M. Loriaux,Heike L. Pahl,Richard T. Silver,Anupriya Agarwal,Thomas O'Hare,Brian J. Druker,Grover C. Bagby,Michael W. Deininger
Platelets and Thrombopoiesis
A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
Clinical Trials & Observations
Adam Cuker,Alasdair J. Coles,Herman Sullivan,Edward Fox,Mark Goldberg,Pedro Oyuela,Annie Purvis,Diana S. Beardsley,David H. Margolin
Red Cells, Iron, and Erythropoiesis
Transplantation
Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions
Clinical Trials & Observations
Hongtao Liu,Elizabeth S. Rich,Lucy Godley,Olatoyosi Odenike,Loren Joseph,Susana Marino,Justin Kline,Vu Nguyen,John Cunningham,Richard A. Larson,Paula del Cerro,Linda Schroeder,Lisa Pape,Wendy Stock,Amittha Wickrema,Andrew S. Artz,Koen van Besien
Vascular Biology
TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow–derived proangiogenic cell differentiation, function, and neovascularization
Akm Khyrul Wara,ShiYin Foo,Kevin Croce,Xinghui Sun,Basak Icli,Yevgenia Tesmenitsky,Fehim Esen,Jung-Soo Lee,Malayannan Subramaniam,Thomas C. Spelsberg,Eli I. Lev,Dorit Leshem-Lev,Reena L. Pande,Mark A. Creager,Anthony Rosenzweig,Mark W. Feinberg
Correspondence
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Cover Image
Cover Image
![issue cover]()
A mitotic figure of a polyploid 16N megakaryocyte from a hematoxylin and eosin–stained bone marrow biopsy section. Analysis of the geometry of this and other megakaryocyte mitotic figures reveals a high order of organization of the polyploid mitotic apparatus, which could provide insights into endomitosis in megakaryocytes and mitosis in general. See the letter to the editor by Anastasi on page 6473.
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