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Volume 118, Issue 24

December 8 2011

In this Issue

Inside Blood
Plenary Paper
Review Articles
Evidence-Based Focused Review
Clinical Trials and Observations
Hematopoiesis and Stem Cells
Immunobiology
Lymphoid Neoplasia
Myeloid Neoplasia
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Transplantation
Vascular Biology
Correspondence

Table of Contents

Inside Blood

CLINICAL TRIALS

From the observation DAC: romidepsin revisited

Stefan Knop

CLINICAL TRIALS

ITP: Tolerance Lost

Patrick F. Fogarty

INSIDE BLOOD

Innovation in myeloma treatments PARP excellence!

Rafael Fonseca

MYELOID NEOPLASIA

Getting to know JAK

Hal E. Broxmeyer

MYELOID NEOPLASIA

It dices, it splices!

Virginia M. Klimek

Plenary Paper

MYELOID NEOPLASIA

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Luca Malcovati,Elli Papaemmanuil,David T. Bowen,Jacqueline Boultwood,Matteo G. Della Porta,Cristiana Pascutto,Erica Travaglino,Michael J. Groves,Anna L. Godfrey,Ilaria Ambaglio,Anna Gallì,Matteo C. Da Vià,Simona Conte,Sudhir Tauro,Norene Keenan,Ann Hyslop,Jonathan Hinton,Laura J. Mudie,James S. Wainscoat,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Eva Hellström-Lindberg,Mario Cazzola,on behalf of the Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium and of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative

Supplemental data

Review Articles

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

Sheryl M. Gough,Christopher I. Slape,Peter D. Aplan

Evidence-Based Focused Review

Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility
Clinical Trials & Observations

Renato D. Lopes,John D. Horowitz,David A. Garcia,Mark A. Crowther,Elaine M. Hylek

Clinical Trials and Observations

Safety of long-term treatment of HAM/TSP patients with valproic acid
Brief Report

Stéphane Olindo,Gildas Belrose,Nicolas Gillet,Sabrina Rodriguez,Mathieu Boxus,Olivier Verlaeten,Becca Asquith,Charles Bangham,Aïssatou Signaté,Didier Smadja,Agnès Lezin,Raymond Césaire,Luc Willems

Hematopoiesis and Stem Cells

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

Dominique Bluteau,Laure Gilles,Morgane Hilpert,Iléana Antony-Debré,Chloe James,Najet Debili,Valerie Camara-Clayette,Orianne Wagner-Ballon,Veronique Cordette-Lagarde,Thomas Robert,Hugues Ripoche,Patrick Gonin,Sabina Swierczek,Josef Prchal,William Vainchenker,Remi Favier,Hana Raslova

Supplemental data

Immunobiology

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling

Franziska Hampel,Stefanie Ehrenberg,Caroline Hojer,Anne Draeseke,Gabriele Marschall-Schröter,Ralf Kühn,Brigitte Mack,Olivier Gires,Christoph J. Vahl,Marc Schmidt-Supprian,Lothar J. Strobl,Ursula Zimber-Strobl

Supplemental data

FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling

Hae Won Sohn,Peter D. Krueger,Randall S. Davis,Susan K. Pierce

Supplemental data

IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
Brief Report

Don M. Benson, Jr,Courtney E. Bakan,Shuhong Zhang,Shauna M. Collins,Jing Liang,Shivani Srivastava,Craig C. Hofmeister,Yvonne Efebera,Pascale Andre,Francois Romagne,Mathieu Bléry,Cécile Bonnafous,Jianying Zhang,David Clever,Michael A. Caligiuri,Sherif S. Farag

Supplemental data

Lymphoid Neoplasia

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma
Clinical Trials & Observations

Simon J. Harrison,Hang Quach,Emma Link,John F. Seymour,David S. Ritchie,Sam Ruell,Joanne Dean,Henry Januszewicz,Ricky Johnstone,Paul Neeson,Michael Dickinson,Jean Nichols,H. Miles Prince

Supplemental data

Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
Clinical Trials & Observations

Ebba K. Lindqvist,Lynn R. Goldin,Ola Landgren,Cecilie Blimark,Ulf-Henrik Mellqvist,Ingemar Turesson,Anders Wahlin,Magnus Björkholm,Sigurdur Y. Kristinsson

Supplemental data

Phase 2 study of PVAG (prednisone, vinblastine, doxorubicin, gemcitabine) in elderly patients with early unfavorable or advanced stage Hodgkin lymphoma
Clinical Trials & Observations

Boris Böll,Henning Bredenfeld,Helen Görgen,Teresa Halbsguth,Hans T. Eich,Martin Soekler,Jana Markova,Ulrich Keller,Ullrich Graeven,Stephan Kremers,Michael Geissler,Guido Trenn,Michael Fuchs,Bastian von Tresckow,Dennis A. Eichenauer,Peter Borchmann,Andreas Engert

SYK inhibition and response prediction in diffuse large B-cell lymphoma

Shuhua Cheng,Greg Coffey,X. Hannah Zhang,Rita Shaknovich,Zibo Song,Pin Lu,Anjali Pandey,Ari M. Melnick,Uma Sinha,Y. Lynn Wang

Supplemental data

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
Clinical Trials & Observations

Fortunato Morabito,Rosaria De Filippi,Luca Laurenti,Katja Zirlik,Anna Grazia Recchia,Massimo Gentile,Emanuela Morelli,Ernesto Vigna,Vincenzo Gigliotti,Rosa Calemma,Barbara Amoroso,Antonino Neri,Giovanna Cutrona,Manlio Ferrarini,Stefano Molica,Giovanni Del Poeta,Claudio Tripodo,Antonio Pinto

Supplemental data

Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
Clinical Trials & Observations

Andrea Kühnl,Nicola Gökbuget,Martin Kaiser,Cornelia Schlee,Andrea Stroux,Thomas Burmeister,Liliana H. Mochmann,Dieter Hoelzer,Wolf-Karsten Hofmann,Eckhard Thiel,Claudia D. Baldus

Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors

Paola Neri,Li Ren,Kathy Gratton,Erin Stebner,Jordan Johnson,Alexander Klimowicz,Peter Duggan,Pierfrancesco Tassone,Adnan Mansoor,Douglas A. Stewart,Sagar Lonial,Lawrence H. Boise,Nizar J. Bahlis

Supplemental data

Endogenous Bcl-x_L is essential for Myc-driven lymphomagenesis in mice

Priscilla N. Kelly,Stephanie Grabow,Alex R. D. Delbridge,Andreas Strasser,Jerry M. Adams

Supplemental data

Myeloid Neoplasia

TNFα facilitates clonal expansion of JAK2^V617F positive cells in myeloproliferative neoplasms

Angela G. Fleischman,Karl J. Aichberger,Samuel B. Luty,Thomas G. Bumm,Curtis L. Petersen,Shirin Doratotaj,Kavin B. Vasudevan,Dorian H. LaTocha,Fei Yang,Richard D. Press,Marc M. Loriaux,Heike L. Pahl,Richard T. Silver,Anupriya Agarwal,Thomas O'Hare,Brian J. Druker,Grover C. Bagby,Michael W. Deininger

Supplemental data

Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
Brief Report

Eliza Vakana,Jessica K. Altman,Heather Glaser,Nicholas J. Donato,Leonidas C. Platanias

Supplemental data

Platelets and Thrombopoiesis

A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
Clinical Trials & Observations

Adam Cuker,Alasdair J. Coles,Herman Sullivan,Edward Fox,Mark Goldberg,Pedro Oyuela,Annie Purvis,Diana S. Beardsley,David H. Margolin

Supplemental data

The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia
Brief Report

Andrew R. Crow,Sara J. Suppa,Xi Chen,Patrick J. Mott,Alan H. Lazarus

Supplemental data

Red Cells, Iron, and Erythropoiesis

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Shilpa M. Hattangadi,Piu Wong,Lingbo Zhang,Johan Flygare,Harvey F. Lodish

The ribosome-related protein, SBDS, is critical for normal erythropoiesis

Saswati Sen,Hanming Wang,Chi Lan Nghiem,Kim Zhou,Janice Yau,Chetankumar S. Tailor,Meredith S. Irwin,Yigal Dror

Supplemental data

Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice

Lara Krieg,Oren Milstein,Philippe Krebs,Yu Xia,Bruce Beutler,Xin Du

Supplemental data

Transplantation

Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation

Xiaojian Wang,Hongmei Li,Catherine Matte-Martone,Weiguo Cui,Ning Li,Hung Sheng Tan,Derry Roopenian,Warren D. Shlomchik

Supplemental data

Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions
Clinical Trials & Observations

Hongtao Liu,Elizabeth S. Rich,Lucy Godley,Olatoyosi Odenike,Loren Joseph,Susana Marino,Justin Kline,Vu Nguyen,John Cunningham,Richard A. Larson,Paula del Cerro,Linda Schroeder,Lisa Pape,Wendy Stock,Amittha Wickrema,Andrew S. Artz,Koen van Besien

Supplemental data

Circulating B-cell activating factor level predicts clinical response of chronic graft-versus-host disease to extracorporeal photopheresis
Brief Report

Robert Whittle,Peter C. Taylor

Vascular Biology

TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow–derived proangiogenic cell differentiation, function, and neovascularization

Akm Khyrul Wara,ShiYin Foo,Kevin Croce,Xinghui Sun,Basak Icli,Yevgenia Tesmenitsky,Fehim Esen,Jung-Soo Lee,Malayannan Subramaniam,Thomas C. Spelsberg,Eli I. Lev,Dorit Leshem-Lev,Reena L. Pande,Mark A. Creager,Anthony Rosenzweig,Mark W. Feinberg

Supplemental data

Bone marrow–derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease
Brief Report

Akm Khyrul Wara,Kevin Croce,ShiYin Foo,Xinghui Sun,Basak Icli,Yevgenia Tesmenitsky,Fehim Esen,Anthony Rosenzweig,Mark W. Feinberg

Supplemental data

Correspondence

Effect of combined dexamethasone/lenalidomide therapy on NK cell–receptor levels in myeloma patients

Clive R. Carter,Sylvia Feyler,Natuley Smalle,Gina B. Scott,Christopher Parrish,Katherine Cullen,Charlotte Kallmeyer,Philip M. Wood,Gordon Cook

Response: dexamethasone dose alters expression of NK activating receptors in vivo

Andy Hsu,Hang Quach,Tsin Tai,H. Miles Prince,Simon J. Harrison,Joseph A. Trapani,Mark J. Smyth,Paul J. Neeson,David S. Ritchie

Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm

Mathias Vilaine,Damla Olcaydu,Ashot Harutyunyan,Jonathan Bergeman,Mourad Tiab,Jean-François Ramée,Jian-Min Chen,Robert Kralovics,Sylvie Hermouet

Supplemental data

Differential expression of MMP-2 and MMP-9 activity in megakaryocytes and platelets

Ferdinando Mannello,Virginia Medda

Response: MMP-9 in platelets: maybe, maybe not

Emanuela Falcinelli,Loredana Bury,Neal Tolley,Marco Malvestiti,Luca Cecchetti,Andy Weyrich,Paolo Gresele

Some observations on the geometry of megakaryocyte mitotic figures: Buckyballs in the bone marrow

John Anastasi

Cover Image

Cover Image

A mitotic figure of a polyploid 16N megakaryocyte from a hematoxylin and eosin–stained bone marrow biopsy section. Analysis of the geometry of this and other megakaryocyte mitotic figures reveals a high order of organization of the polyploid mitotic apparatus, which could provide insights into endomitosis in megakaryocytes and mitosis in general. See the letter to the editor by Anastasi on page 6473.
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