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How I treat autoimmune lymphoproliferative syndrome
Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment
Anti–Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
Pivotal trial with plant cell–expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation
Issue Archive
November 24 2011
In this Issue
Table of Contents
Inside Blood
Plenary Paper
Review Article
How I Treat
How I treat autoimmune lymphoproliferative syndrome
Clinical Trials & Observations
Immunobiology
Lymphoid Neoplasia
Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
CME
Philippe Moreau,Herve Avet-Loiseau,Thierry Facon,Michel Attal,Mourad Tiab,Cyrille Hulin,Chantal Doyen,Laurent Garderet,Edouard Randriamalala,Carla Araujo,Gérard Lepeu,Gerald Marit,Denis Caillot,Martine Escoffre,Bruno Lioure,Lotfi Benboubker,Brigitte Pégourié,Brigitte Kolb,Anne Marie Stoppa,Jean-Gabriel Fuzibet,Olivier Decaux,Mamoun Dib,Christian Berthou,Carine Chaleteix,Catherine Sebban,Catherine Traullé,Jean Fontan,Marc Wetterwald,Pascal Lenain,Claire Mathiot,Jean-Luc Harousseau
Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment
Clinical Trials & Observations
Fortunato Morabito,Massimo Gentile,Carla Mazzone,Davide Rossi,Francesco Di Raimondo,Sara Bringhen,Roberto Ria,Massimo Offidani,Francesca Patriarca,Chiara Nozzoli,Maria Teresa Petrucci,Giulia Benevolo,Iolanda Vincelli,Tommasina Guglielmelli,Mariella Grasso,Roberto Marasca,Luca Baldini,Vittorio Montefusco,Pellegrino Musto,Nicola Cascavilla,Ignazio Majolino,Caterina Musolino,Michele Cavo,Mario Boccadoro,Antonio Palumbo
Anti–Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials
Clinical Trials & Observations
Andrea Willer,Joachim Gerß,Thorsten König,Dieter Franke,Hans-Jürgen Kühnel,Günter Henze,Arendt von Stackelberg,Anja Möricke,Martin Schrappe,Joachim Boos,Claudia Lanvers-Kaminsky
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
Clinical Trials & Observations
Julie Rousseau,Vincent Gagné,Malgorzata Labuda,Cyrielle Beaubois,Daniel Sinnett,Caroline Laverdière,Albert Moghrabi,Stephen E. Sallan,Lewis B. Silverman,Donna Neuberg,Jeffery L. Kutok,Maja Krajinovic
Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Ulrik Ralfkiaer,Peter H. Hagedorn,Nannie Bangsgaard,Marianne B. Løvendorf,Charlotte B. Ahler,Lars Svensson,Katharina L. Kopp,Marie T. Vennegaard,Britt Lauenborg,John R. Zibert,Thorbjørn Krejsgaard,Charlotte M. Bonefeld,Rolf Søkilde,Lise M. Gjerdrum,Tord Labuda,Anne-Merete Mathiesen,Kirsten Grønbæk,Mariusz A. Wasik,Malgorzata Sokolowska-Wojdylo,Catherine Queille-Roussel,Robert Gniadecki,Elisabeth Ralfkiaer,Carsten Geisler,Thomas Litman,Anders Woetmann,Christian Glue,Mads A. Røpke,Lone Skov,Niels Odum
Myeloid Neoplasia
Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
Clinical Trials & Observations
Anna Staffas,Meena Kanduri,Randi Hovland,Richard Rosenquist,Hans Beier Ommen,Jonas Abrahamsson,Erik Forestier,Kirsi Jahnukainen,Ólafur G. Jónsson,Bernward Zeller,Josefine Palle,Gudmar Lönnerholm,Henrik Hasle,Lars Palmqvist,Hans Ehrencrona,on behalf of the Nordic Society of Pediatric Hematology and Oncology (NOPHO)
Phagocytes, Granulocytes, and Myelopoiesis
Pivotal trial with plant cell–expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease
Clinical Trials & Observations
Ari Zimran,Einat Brill-Almon,Raul Chertkoff,Milan Petakov,Francisco Blanco-Favela,Eduardo Terreros Muñoz,Sergio E. Solorio-Meza,Dominick Amato,Gloria Duran,Fiorina Giona,Rene Heitner,Hanna Rosenbaum,Pilar Giraldo,Atul Mehta,Glen Park,Mici Phillips,Deborah Elstein,Gheona Altarescu,Mali Szleifer,Sharon Hashmueli,David Aviezer
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Clinical Trials & Observations
Marie Meeths,Samuel C. C. Chiang,Stephanie M. Wood,Miriam Entesarian,Heinrich Schlums,Benedicte Bang,Edvard Nordenskjöld,Caroline Björklund,Gordana Jakovljevic,Janez Jazbec,Henrik Hasle,Britt-Marie Holmqvist,Ljubica Rajić,Susan Pfeifer,Steen Rosthøj,Magnus Sabel,Toivo T. Salmi,Tore Stokland,Jacek Winiarski,Hans-Gustaf Ljunggren,Bengt Fadeel,Magnus Nordenskjöld,Jan-Inge Henter,Yenan T. Bryceson
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
Clinical Trials & Observations
Kejian Zhang,Michael B. Jordan,Rebecca A. Marsh,Judith A. Johnson,Diane Kissell,Jarek Meller,Joyce Villanueva,Kimberly A. Risma,Qian Wei,Peter S. Klein,Alexandra H. Filipovich
Platelets and Thrombopoiesis
Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome
Clinical Trials & Observations
Paquita Nurden,Najet Debili,Isabelle Coupry,Marijke Bryckaert,Ibtissam Youlyouz-Marfak,Guilhem Solé,Anne-Cécile Pons,Eliane Berrou,Frédéric Adam,Alexandre Kauskot,Jean-Marie Daniel Lamazière,Philippe Rameau,Patricia Fergelot,Caroline Rooryck,Dorothée Cailley,Benoît Arveiler,Didier Lacombe,William Vainchenker,Alan Nurden,Cyril Goizet
Red Cells, Iron, and Erythropoiesis
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
e-blood
Mayka Sanchez,Bruno Galy,Bjoern Schwanhaeusser,Jonathon Blake,Tomi Bähr-Ivacevic,Vladimir Benes,Matthias Selbach,Martina U. Muckenthaler,Matthias W. Hentze
Thrombosis and Hemostasis
Transplantation
Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation
Clinical Trials & Observations
Stefan O. Ciurea,Peter F. Thall,Xuemei Wang,Sa A. Wang,Ying Hu,Pedro Cano,Fleur Aung,Gabriela Rondon,Jeffrey J. Molldrem,Martin Korbling,Elizabeth J. Shpall,Marcos de Lima,Richard E. Champlin,Marcelo Fernandez-Vina
Correspondence
Other Departments
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Cover Image
Cover Image
![issue cover]()
Three-dimensional computed tomography reconstruction showing massive splenomegaly in a 9-year-old boy with autoimmune lymphoproliferative syndrome (ALPS). Spleen volume as measured by digital image processing was 1972 cm3 in this boy who has been maintained on therapy with mycophenolate mofetil for chronic refractory cytopenias for the last 8 years. Cover image courtesy of Dr Les Folio, DO, MPH, Colonel, USAF (retired), Lead Radiologist for Computed Tomography, Radiology and Imaging Sciences, NIH Clinical Center. See the article by Rao and Oliveira on page 5741.
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