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Volume 118, Issue 22

November 24 2011

Inside Blood
Plenary Paper
Review Article
How I Treat
Immunobiology
Lymphoid Neoplasia
Myeloid Neoplasia
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Transplantation
Correspondence
Other Departments

Table of Contents

Inside Blood

IMMUNOBIOLOGY

Finally, function for “IL-1Fs”

Martin J. H. Nicklin

CLINICAL TRIALS

Immunodeficiency diagnosis: a Mondrian or Pollock scenario?

Claudio Pignata,Giuliana Giardino

INSIDE BLOOD

Adipokines in MM: time to trim the fat

Madhav V. Dhodapkar

INSIDE BLOOD

Early CTCL diagnosis, a (miR)age no more?

Anjali Mishra,Pierluigi Porcu

PHAGOCYTES & GRANULOCYTES

Go girls! Efficient female innate immunity

Sarah E. M. Howie

RED CELLS & IRON

Stomping out barriers for hRBC mouse models

Erin A. Kimbrel,Robert Lanza

TRANSPLANTATION

Vaccinating donors to improve GVL

Geoffrey R. Hill

Plenary Paper

IMMUNOBIOLOGY

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

Erin C. Zook,Paulette A. Krishack,Shubin Zhang,Nancy J. Zeleznik-Le,Anthony B. Firulli,Pamela L. Witte,Phong T. Le

Supplemental data

Review Article

AU-rich RNA binding proteins in hematopoiesis and leukemogenesis

Maria Baou,John D. Norton,John J. Murphy

How I Treat

How I treat autoimmune lymphoproliferative syndrome
Clinical Trials & Observations

V. Koneti Rao,João Bosco Oliveira

Immunobiology

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination

Nichole R. Klatt,Carol L. Vinton,Rebecca M. Lynch,Lauren A. Canary,Jason Ho,Patricia A. Darrah,Jacob D. Estes,Robert A. Seder,Susan L. Moir,Jason M. Brenchley

Supplemental data

IL-36R ligands are potent regulators of dendritic and T cells

Solenne Vigne,Gaby Palmer,Céline Lamacchia,Praxedis Martin,Dominique Talabot-Ayer,Emiliana Rodriguez,Francesca Ronchi,Federica Sallusto,Huyen Dinh,John E. Sims,Cem Gabay

Supplemental data

HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS

Haishan Li,C. David Pauza

Supplemental data

TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow

Shoichiro Tsuji,Catarina Cortesão,Richard J. Bram,Jeffrey L. Platt,Marilia Cascalho

Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56^bright and CD56^dim NK cells

Fabio Morandi,Elisa Ferretti,Roberta Castriconi,Alessandra Dondero,Andrea Petretto,Cristina Bottino,Vito Pistoia

Supplemental data

LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function

Natalie M. Reisman,Tamara L. Floyd,Maylene E. Wagener,Allan D. Kirk,Christian P. Larsen,Mandy L. Ford

Supplemental data

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

Keri B. Sanborn,Emily M. Mace,Gregory D. Rak,Analisa Difeo,John A. Martignetti,Alessandro Pecci,James B. Bussel,Rémi Favier,Jordan S. Orange

Supplemental data

In vivo structure/function and expression analysis of the CX₃C chemokine fractalkine
e-blood

Ki-Wook Kim,Alexandra Vallon-Eberhard,Ehud Zigmond,Julia Farache,Elias Shezen,Guy Shakhar,Andreas Ludwig,Sergio A. Lira,Steffen Jung

Supplemental data

Lymphoid Neoplasia

Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
CME

Philippe Moreau,Herve Avet-Loiseau,Thierry Facon,Michel Attal,Mourad Tiab,Cyrille Hulin,Chantal Doyen,Laurent Garderet,Edouard Randriamalala,Carla Araujo,Gérard Lepeu,Gerald Marit,Denis Caillot,Martine Escoffre,Bruno Lioure,Lotfi Benboubker,Brigitte Pégourié,Brigitte Kolb,Anne Marie Stoppa,Jean-Gabriel Fuzibet,Olivier Decaux,Mamoun Dib,Christian Berthou,Carine Chaleteix,Catherine Sebban,Catherine Traullé,Jean Fontan,Marc Wetterwald,Pascal Lenain,Claire Mathiot,Jean-Luc Harousseau

Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment
Clinical Trials & Observations

Fortunato Morabito,Massimo Gentile,Carla Mazzone,Davide Rossi,Francesco Di Raimondo,Sara Bringhen,Roberto Ria,Massimo Offidani,Francesca Patriarca,Chiara Nozzoli,Maria Teresa Petrucci,Giulia Benevolo,Iolanda Vincelli,Tommasina Guglielmelli,Mariella Grasso,Roberto Marasca,Luca Baldini,Vittorio Montefusco,Pellegrino Musto,Nicola Cascavilla,Ignazio Majolino,Caterina Musolino,Michele Cavo,Mario Boccadoro,Antonio Palumbo

Anti–Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials
Clinical Trials & Observations

Andrea Willer,Joachim Gerß,Thorsten König,Dieter Franke,Hans-Jürgen Kühnel,Günter Henze,Arendt von Stackelberg,Anja Möricke,Martin Schrappe,Joachim Boos,Claudia Lanvers-Kaminsky

Supplemental data

Alemtuzumab therapy in T-cell prolymphocytic leukemia: comparing efficacy in a series treated intravenously and a study piloting the subcutaneous route
Brief Report

Claire E. Dearden,Amit Khot,Monica Else,Mike Hamblin,Effie Grand,Ashok Roy,Saman Hewamana,Estella Matutes,Daniel Catovsky

Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease

Jessica A. Fowler,Seint T. Lwin,Matthew T. Drake,James R. Edwards,Robert A. Kyle,Gregory R. Mundy,Claire M. Edwards

Supplemental data

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Julie Rousseau,Vincent Gagné,Malgorzata Labuda,Cyrielle Beaubois,Daniel Sinnett,Caroline Laverdière,Albert Moghrabi,Stephen E. Sallan,Lewis B. Silverman,Donna Neuberg,Jeffery L. Kutok,Maja Krajinovic

Supplemental data

Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)

Ulrik Ralfkiaer,Peter H. Hagedorn,Nannie Bangsgaard,Marianne B. Løvendorf,Charlotte B. Ahler,Lars Svensson,Katharina L. Kopp,Marie T. Vennegaard,Britt Lauenborg,John R. Zibert,Thorbjørn Krejsgaard,Charlotte M. Bonefeld,Rolf Søkilde,Lise M. Gjerdrum,Tord Labuda,Anne-Merete Mathiesen,Kirsten Grønbæk,Mariusz A. Wasik,Malgorzata Sokolowska-Wojdylo,Catherine Queille-Roussel,Robert Gniadecki,Elisabeth Ralfkiaer,Carsten Geisler,Thomas Litman,Anders Woetmann,Christian Glue,Mads A. Røpke,Lone Skov,Niels Odum

Supplemental data

Epigenetic inactivation of the MIR34B/C in multiple myeloma
Brief Report

Kwan Yeung Wong,Rita Lok Hay Yim,Chi Chiu So,Dong-Yan Jin,Raymond Liang,Chor Sang Chim

Supplemental data

Myeloid Neoplasia

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
Clinical Trials & Observations

Anna Staffas,Meena Kanduri,Randi Hovland,Richard Rosenquist,Hans Beier Ommen,Jonas Abrahamsson,Erik Forestier,Kirsi Jahnukainen,Ólafur G. Jónsson,Bernward Zeller,Josefine Palle,Gudmar Lönnerholm,Henrik Hasle,Lars Palmqvist,Hans Ehrencrona,on behalf of the Nordic Society of Pediatric Hematology and Oncology (NOPHO)

Supplemental data

Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia
Brief Report

Meng Li,Roxane Collins,Yuchen Jiao,Peter Ouillette,Dale Bixby,Harry Erba,Bert Vogelstein,Kenneth W. Kinzler,Nickolas Papadopoulos,Sami N. Malek

Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Pivotal trial with plant cell–expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease
Clinical Trials & Observations

Ari Zimran,Einat Brill-Almon,Raul Chertkoff,Milan Petakov,Francisco Blanco-Favela,Eduardo Terreros Muñoz,Sergio E. Solorio-Meza,Dominick Amato,Gloria Duran,Fiorina Giona,Rene Heitner,Hanna Rosenbaum,Pilar Giraldo,Atul Mehta,Glen Park,Mici Phillips,Deborah Elstein,Gheona Altarescu,Mali Szleifer,Sharon Hashmueli,David Aviezer

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Clinical Trials & Observations

Marie Meeths,Samuel C. C. Chiang,Stephanie M. Wood,Miriam Entesarian,Heinrich Schlums,Benedicte Bang,Edvard Nordenskjöld,Caroline Björklund,Gordana Jakovljevic,Janez Jazbec,Henrik Hasle,Britt-Marie Holmqvist,Ljubica Rajić,Susan Pfeifer,Steen Rosthøj,Magnus Sabel,Toivo T. Salmi,Tore Stokland,Jacek Winiarski,Hans-Gustaf Ljunggren,Bengt Fadeel,Magnus Nordenskjöld,Jan-Inge Henter,Yenan T. Bryceson

Supplemental data

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
Clinical Trials & Observations

Kejian Zhang,Michael B. Jordan,Rebecca A. Marsh,Judith A. Johnson,Diane Kissell,Jarek Meller,Joyce Villanueva,Kimberly A. Risma,Qian Wei,Peter S. Klein,Alexandra H. Filipovich

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

Ramona S. Scotland,Melanie J. Stables,Shimona Madalli,Peter Watson,Derek W. Gilroy

Supplemental data

Platelets and Thrombopoiesis

Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome
Clinical Trials & Observations

Paquita Nurden,Najet Debili,Isabelle Coupry,Marijke Bryckaert,Ibtissam Youlyouz-Marfak,Guilhem Solé,Anne-Cécile Pons,Eliane Berrou,Frédéric Adam,Alexandre Kauskot,Jean-Marie Daniel Lamazière,Philippe Rameau,Patricia Fergelot,Caroline Rooryck,Dorothée Cailley,Benoît Arveiler,Didier Lacombe,William Vainchenker,Alan Nurden,Cyril Goizet

Supplemental data

Red Cells, Iron, and Erythropoiesis

Macrophages prevent human red blood cell reconstitution in immunodeficient mice

Zheng Hu,Nico Van Rooijen,Yong-Guang Yang

Supplemental data

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
e-blood

Mayka Sanchez,Bruno Galy,Bjoern Schwanhaeusser,Jonathon Blake,Tomi Bähr-Ivacevic,Vladimir Benes,Matthias Selbach,Martina U. Muckenthaler,Matthias W. Hentze

Supplemental data

Thrombosis and Hemostasis

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies

Eveline A. M. Bouwens,Marjon J. Mourik,Maartje van den Biggelaar,Jeroen C. J. Eikenboom,Jan Voorberg,Karine M. Valentijn,Koen Mertens

Supplemental data

Transplantation

Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation
Clinical Trials & Observations

Stefan O. Ciurea,Peter F. Thall,Xuemei Wang,Sa A. Wang,Ying Hu,Pedro Cano,Fleur Aung,Gabriela Rondon,Jeffrey J. Molldrem,Martin Korbling,Elizabeth J. Shpall,Marcos de Lima,Richard E. Champlin,Marcelo Fernandez-Vina

Memory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution

Ning Li,Catherine Matte-Martone,Hong Zheng,Weiguo Cui,Srividhya Venkatesan,Hung Sheng Tan,Jennifer McNiff,Anthony J. Demetris,Derry Roopenian,Susan Kaech,Warren D. Shlomchik

Supplemental data

Correspondence

Response: common variable immunodeficiency patients with increased CD21^−/lo B cells suffer from altered receptor editing and defective central B-cell tolerance

Neil Romberg,Yen-Shing Ng,Charlotte Cunningham-Rundles,Eric Meffre

Activated primary human B cells efficiently induce early CD40L and CD107a expression in CD4⁺ T cells

Sebastian Theurich,Joke Malcher,Hans J. Becker,Jens M. Chemnitz,Tanja M. Liebig,Alexander Shimabukuro-Vornhagen,Michael von Bergwelt-Baildon

Response: peripheral blood monocytes, but not resting, activated, or transformed B cells, costimulate early CD40L expression

Nicholas D. Bushar,James T. Snyder,Sagarika Chakrabarty,Jijia Shen,Qian Chen,Jack A. Ragheb

Other Departments

Continuing Medical Education (CME) questions: bortezomib, thalidomide, and dexamethasone in multiple myeloma
CME

Cover Image

Cover Image

Three-dimensional computed tomography reconstruction showing massive splenomegaly in a 9-year-old boy with autoimmune lymphoproliferative syndrome (ALPS). Spleen volume as measured by digital image processing was 1972 cm³ in this boy who has been maintained on therapy with mycophenolate mofetil for chronic refractory cytopenias for the last 8 years. Cover image courtesy of Dr Les Folio, DO, MPH, Colonel, USAF (retired), Lead Radiologist for Computed Tomography, Radiology and Imaging Sciences, NIH Clinical Center. See the article by Rao and Oliveira on page 5741.
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