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Issue Archive

Volume 118, Issue 20
November 17 2011
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
The kiss of death in FL
Alan G. Ramsay,John G. Gribben
View Articletitled, The kiss of death in FL
MYELOID NEOPLASIA
Gene mutation and AML pathogenesis
Hervé Dombret
View Articletitled, Gene mutation and AML pathogenesis
VASCULAR BIOLOGY
Angiogenesis: the HETE is on
Lalitha Nayak,Mukesh K. Jain
View Articletitled, Angiogenesis: the HETE is on

Blood Work

Basophilic stippling: a lead to the diagnosis
Javier Munoz,Yue Guo
View Articletitled, Basophilic stippling: a lead to the diagnosis

Plenary Paper

PLENARY PAPER
Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study
Camille Laurent,Sabina Müller,Catherine Do,Talal Al-Saati,Sophie Allart,Luigi Maria Larocca,Stefan Hohaus,Sophie Duchez,Anne Quillet-Mary,Guy Laurent,Pierre Brousset,Salvatore Valitutti
View Articletitled, Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study
Supplemental data

Perspectives

Funding mechanisms and program management at the National Heart, Lung, and Blood Institute: confronting new challenges and exploring new opportunities
Susan B. Shurin
View Articletitled, Funding mechanisms and program management at the National Heart, Lung, and Blood Institute: confronting new challenges and exploring new opportunities

Review Article

Mast cell modulation of the vascular and lymphatic endothelium
Christian A. Kunder,Ashley L. St John,Soman N. Abraham
View Articletitled, Mast cell modulation of the vascular and lymphatic endothelium

How I Treat

How I treat pregnancy-related venous thromboembolism
Saskia Middeldorp
View Articletitled, How I treat pregnancy-related venous thromboembolism

Clinical Trials and Observations

A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
Clinical Trials & Observations
Gary J. Vanasse,Jee-Yeong Jeong,Janet Tate,Harini Bathulapalli,Damon Anderson,Hanno Steen,Mark Fleming,Kristin Mattocks,Amalio Telenti,Jacques Fellay,Amy C. Justice,Nancy Berliner
View Articletitled, A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
Brief Report
Leonardo Potenza,Daniela Vallerini,Patrizia Barozzi,Giovanni Riva,Fabio Forghieri,Eleonora Zanetti,Chiara Quadrelli,Anna Candoni,Johan Maertens,Giulio Rossi,Monica Morselli,Mauro Codeluppi,Ambra Paolini,Monica Maccaferri,Cinzia Del Giovane,Roberto D'Amico,Fabio Rumpianesi,Monica Pecorari,Francesca Cavalleri,Roberto Marasca,Franco Narni,Mario Luppi
View Articletitled, <em>Mucorales</em>-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
Supplemental data
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
Clinical Trials & Observations
Yang Shen,Yong-Mei Zhu,Xing Fan,Jing-Yi Shi,Qin-Rong Wang,Xiao-Jing Yan,Zhao-Hui Gu,Yan-Yan Wang,Bing Chen,Chun-Lei Jiang,Han Yan,Fei-Fei Chen,Hai-Min Chen,Zhu Chen,Jie Jin,Sai-Juan Chen
View Articletitled, Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
Supplemental data

Gene Therapy

Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release
Ruei-Zeng Lin,Alexandra Dreyzin,Kristie Aamodt,Dan Li,Shou-Ching S. Jaminet,Andrew C. Dudley,Juan M. Melero-Martin
View Articletitled, Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release
Supplemental data

Hematopoiesis and Stem Cells

The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
Jing Wang,Fei Han,Juan Wu,Szu-Wei Lee,Chia-Hsin Chan,Ching-Yuan Wu,Wei-Lei Yang,Yuan Gao,Xian Zhang,Yun Seong Jeong,Asad Moten,Felipe Samaniego,Peng Huang,Quentin Liu,Yi-Xin Zeng,Hui-Kuan Lin
View Articletitled, The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
Supplemental data
Identification of the earliest natural killer cell–committed progenitor in murine bone marrow
John W. Fathman,Deepta Bhattacharya,Matthew A. Inlay,Jun Seita,Holger Karsunky,Irving L. Weissman
View Articletitled, Identification of the earliest natural killer cell–committed progenitor in murine bone marrow
Supplemental data
Methionine aminopeptidase 2 is required for HSC initiation and proliferation
Alvin C. H. Ma,Tsz K. Fung,Rachel H. C. Lin,Martin I. S. Chung,Dan Yang,Stephen C. Ekker,Anskar Y. H. Leung
View Articletitled, Methionine aminopeptidase 2 is required for HSC initiation and proliferation
Supplemental data
A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization
Tamara C. Pereboom,Linda J. van Weele,Albert Bondt,Alyson W. MacInnes
View Articletitled, A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization
Supplemental data

Immunobiology

Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity
Tae-Don Kim,Su Ui Lee,Sohyun Yun,Hu-Nan Sun,Suk Hyung Lee,Jae Wha Kim,Hwan Mook Kim,Song-Kyu Park,Chang Woo Lee,Suk Ran Yoon,Philip D. Greenberg,Inpyo Choi
View Articletitled, Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity
Supplemental data
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
Shan Jiang,Chaoran Li,Virginie Olive,Erik Lykken,Feng Feng,Jose Sevilla,Ying Wan,Lin He,Qi-Jing Li
View Articletitled, Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
Supplemental data
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
Nataša Obermajer,Ravikumar Muthuswamy,Jamie Lesnock,Robert P. Edwards,Pawel Kalinski
View Articletitled, Positive feedback between PGE<sub>2</sub> and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
Supplemental data

Lymphoid Neoplasia

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL
Matko Kalac,Luigi Scotto,Enrica Marchi,Jennifer Amengual,Venkatraman E. Seshan,Govind Bhagat,Netha Ulahannan,Violetta V. Leshchenko,Alexis M. Temkin,Samir Parekh,Benjamin Tycko,Owen A. O'Connor
View Articletitled, HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL
Supplemental data
PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma
Cristina Gómez-Abad,Helena Pisonero,Carmen Blanco-Aparicio,Giovanna Roncador,Alberto González-Menchén,Jose A. Martinez-Climent,Eva Mata,María Elena Rodríguez,Guillermo Muñoz-González,Margarita Sánchez-Beato,Juan F. Leal,James R. Bischoff,Miguel A. Piris
View Articletitled, PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma
Supplemental data
Endoplasmic reticulum stress causes EBV lytic replication
Gwen Marie Taylor,Sandeep K. Raghuwanshi,David T. Rowe,Robert M. Wadowsky,Adam Rosendorff
View Articletitled, Endoplasmic reticulum stress causes EBV lytic replication
Supplemental data
Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity
Sherine F. Elsawa,Anne J. Novak,Steven C. Ziesmer,Luciana L. Almada,Lucy S. Hodge,Deanna M. Grote,Thomas E. Witzig,Martin E. Fernandez-Zapico,Stephen M. Ansell
View Articletitled, Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity
MicroRNA profiles of t(14;18)–negative follicular lymphoma support a late germinal center B-cell phenotype
Ellen Leich,Alberto Zamo,Heike Horn,Eugenia Haralambieva,Bernhard Puppe,Randy D. Gascoyne,Wing-Chung Chan,Rita M. Braziel,Lisa M. Rimsza,Dennis D. Weisenburger,Jan Delabie,Elaine S. Jaffe,Jude Fitzgibbon,Louis M. Staudt,Hans-Konrad Mueller-Hermelink,Mariarita Calaminici,Elias Campo,German Ott,Luis Hernández,Andreas Rosenwald
View Articletitled, MicroRNA profiles of t(14;18)–negative follicular lymphoma support a late germinal center B-cell phenotype
Supplemental data
Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia
Giovanni Cazzaniga,Frederik W. van Delft,Luca Lo Nigro,Anthony M. Ford,Joannah Score,Ilaria Iacobucci,Elena Mirabile,Mary Taj,Susan M. Colman,Andrea Biondi,Mel Greaves
View Articletitled, Developmental origins and impact of <em>BCR-ABL1</em> fusion and <em>IKZF1</em> deletions in monozygotic twins with Ph<sup>+</sup> acute lymphoblastic leukemia

Myeloid Neoplasia

Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16)
Clinical Trials & Observations
Ursula Creutzig,Martin Zimmermann,Jean-Pierre Bourquin,Michael N. Dworzak,Christine von Neuhoff,Annette Sander,André Schrauder,Andrea Teigler-Schlegel,Jan Starý,Selim Corbacioglu,Dirk Reinhardt
View Articletitled, Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16)
Supplemental data
Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
Su Chu,Tinisha McDonald,Allen Lin,Sujata Chakraborty,Qin Huang,David S. Snyder,Ravi Bhatia
View Articletitled, Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
Supplemental data
Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
Stefan Deneberg,Philippe Guardiola,Andreas Lennartsson,Ying Qu,Verena Gaidzik,Odile Blanchet,Mohsen Karimi,Sofia Bengtzén,Hareth Nahi,Bertil Uggla,Ulf Tidefelt,Martin Höglund,Christer Paul,Karl Ekwall,Konstanze Döhner,Sören Lehmann
View Articletitled, Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
Supplemental data
Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
Olga Blau,Claudia Dorothea Baldus,Wolf-Karsten Hofmann,Gundula Thiel,Florian Nolte,Thomas Burmeister,Seval Türkmen,Ouidad Benlasfer,Elke Schümann,Annette Sindram,Mara Molkentin,Stefan Mundlos,Ulrich Keilholz,Eckhard Thiel,Igor Wolfgang Blau
View Articletitled, Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia
Steven M. Kornblau,Yi Hua Qiu,Nianxiang Zhang,Neera Singh,Stefan Faderl,Alessandra Ferrajoli,Heather York,Amina A. Qutub,Kevin R. Coombes,Dennis K. Watson
View Articletitled, Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia
Supplemental data
High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9–positive patients
Sylvie M. Noordermeer,Mathijs A. Sanders,Christian Gilissen,Evelyn Tönnissen,Adrian van der Heijden,Konstanze Döhner,Lars Bullinger,Joop H. Jansen,Peter J. M. Valk,Bert A. van der Reijden
View Articletitled, High <em>BRE</em> expression predicts favorable outcome in adult acute myeloid leukemia, in particular among <em>MLL-AF9</em>–positive patients
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
Yasuko Furumoto,Nicolas Charles,Ana Olivera,Wai Hang Leung,Sandra Dillahunt,Jennifer L. Sargent,Kevin Tinsley,Sandra Odom,Eric Scott,Todd M. Wilson,Kamran Ghoreschi,Manfred Kneilling,Mei Chen,David M. Lee,Silvia Bolland,Juan Rivera
View Articletitled, PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
Supplemental data
Regulation of macrophage migration by a novel plasminogen receptor Plg-RKT
Shahrzad Lighvani,Nagyung Baik,Jenna E. Diggs,Sophia Khaldoyanidi,Robert J. Parmer,Lindsey A. Miles
View Articletitled, Regulation of macrophage migration by a novel plasminogen receptor Plg-R<sub>KT</sub>
Supplemental data

Platelets and Thrombopoiesis

Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling
Lorena Buitrago,Wallace Y. Langdon,Archana Sanjay,Satya P. Kunapuli
View Articletitled, Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling
Supplemental data
An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets
Shaista Nisar,Martina E. Daly,Augusto B. Federici,Andrea Artoni,Andrew D. Mumford,Stephen P. Watson,Stuart J. Mundell
View Articletitled, An intact PDZ motif is essential for correct P2Y<sub>12</sub> purinoceptor traffic in human platelets
Supplemental data

Red Cells, Iron, and Erythropoiesis

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity
Lucia De Franceschi,Carlo Tomelleri,Alessandro Matte,Anna Maria Brunati,Petra H. Bovee-Geurts,Mariarita Bertoldi,Edwin Lasonder,Elena Tibaldi,Adrian Danek,Ruth H. Walker,Hans H. Jung,Benedikt Bader,Angela Siciliano,Emanuela Ferru,Narla Mohandas,Giel J. C. G. M. Bosman
View Articletitled, Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity
Supplemental data
Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia
Aisha L. Walker,Shirley Steward,Thad A. Howard,Nicole Mortier,Matthew Smeltzer,Yong-Dong Wang,Russell E. Ware
View Articletitled, Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia
Supplemental data

Transplantation

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
Anandharaman Veerapathran,Joseph Pidala,Francisca Beato,Xue-Zhong Yu,Claudio Anasetti
View Articletitled, Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
Supplemental data
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation
Clinical Trials & Observations
Eva Rettinger,Andre M. Willasch,Hermann Kreyenberg,Arndt Borkhardt,Wolfgang Holter,Bernhard Kremens,Brigitte Strahm,Wilhelm Woessmann,Christine Mauz-Koerholz,Bernd Gruhn,Stefan Burdach,Michael H. Albert,Paul-Gerhardt Schlegel,Thomas Klingebiel,Peter Bader
View Articletitled, Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation
Supplemental data
Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients
Clinical Trials & Observations
Filippo Milano,Steven A. Pergam,Hu Xie,Wendy M. Leisenring,Jonathan A. Gutman,Ivy Riffkin,Victor Chow,Michael J. Boeckh,Colleen Delaney
View Articletitled, Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients
Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias
Brief Report
Franck Emmanuel Nicolini,Grzegorz W. Basak,Simona Soverini,Giovanni Martinelli,Michael J. Mauro,Martin C. Müller,Andreas Hochhaus,Charles Chuah,Inge H. Dufva,Giovanna Rege-Cambrin,Giuseppe Saglio,Mauricette Michallet,Hélène Labussière,Stéphane Morisset,Sandrine Hayette,Gabriel Etienne,Eduardo Olavarria,Wei Zhou,Senaka Peter,Jane F. Apperley,Jorge Cortes
View Articletitled, Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias

Vascular Biology

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation
Nikhlesh K. Singh,Venkatesh Kundumani-Sridharan,Gadiparthi N. Rao
View Articletitled, 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation
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