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Issue Archive

Volume 118, Issue 19
November 10 2011
Issue Cover

Table of Contents

Inside Blood

PLATELETS & THROMBOPOIESIS
Structural mix-n-match reveals molecular secrets of platelets
Bostjan Kobe
View Articletitled, Structural mix-n-match reveals molecular secrets of platelets
CLINICAL TRIALS
Anti-CD20: tales of identical twins?
Anna Schuh
View Articletitled, Anti-CD20: tales of identical twins?
THROMBOSIS & HEMOSTASIS
SHEARiO, fast lane to oxidized VWF
Peter J. Lenting
View Articletitled, SHEAR<em>i</em>O, fast lane to oxidized VWF
TRANSFUSION MEDICINE
Brewing blood
Harvey G. Klein
View Articletitled, Brewing blood

Plenary Paper

Red Cells, Iron, and Erythropoiesis
Proof of principle for transfusion of in vitro–generated red blood cells
Marie-Catherine Giarratana,Hélène Rouard,Agnès Dumont,Laurent Kiger,Innocent Safeukui,Pierre-Yves Le Pennec,Sabine François,Germain Trugnan,Thierry Peyrard,Tiffany Marie,Séverine Jolly,Nicolas Hebert,Christelle Mazurier,Nathalie Mario,Laurence Harmand,Hélène Lapillonne,Jean-Yves Devaux,Luc Douay
View Articletitled, Proof of principle for transfusion of in vitro–generated red blood cells
Supplemental data

Perspectives

Lack of clarity in the definition of treatment-related mortality: pediatric acute leukemia and adult acute promyelocytic leukemia as examples
Clinical Trials & Observations
Marie-Chantal Ethier,Esther Blanco,Thomas Lehrnbecher,Lillian Sung
View Articletitled, Lack of clarity in the definition of treatment-related mortality: pediatric acute leukemia and adult acute promyelocytic leukemia as examples
Supplemental data

Review Article

Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
Celalettin Ustun,Jeffrey S. Miller,David H. Munn,Daniel J. Weisdorf,Bruce R. Blazar
View Articletitled, Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?

Blood Consult

Blood consult: high Sokal risk chronic myeloid leukemia and suboptimal response
Clinical Trials & Observations
Lydia Roy,Cécile Tomowiak,François Guilhot
View Articletitled, <em>Blood</em> consult: high Sokal risk chronic myeloid leukemia and suboptimal response

Gene Therapy

Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes
Brief Report
Christian Hofmann,Sandra Höfflin,Angela Hückelhoven,Silke Bergmann,Ellen Harrer,Gerold Schuler,Jan Dörrie,Niels Schaft,Thomas Harrer
View Articletitled, Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes

Immunobiology

Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
Clinical Trials & Observations
Monia Ouederni,Quentin B. Vincent,Pierre Frange,Fabien Touzot,Sami Scerra,Mohamed Bejaoui,Aziz Bousfiha,Yves Levy,Barbara Lisowska-Grospierre,Danielle Canioni,Julie Bruneau,Marianne Debré,Stéphane Blanche,Laurent Abel,Jean-Laurent Casanova,Alain Fischer,Capucine Picard
View Articletitled, Major histocompatibility complex class II expression deficiency caused by a <em>RFXANK</em> founder mutation: a survey of 35 patients
Supplemental data
CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues
Vanja Sisirak,Nelly Vey,Béatrice Vanbervliet,Thomas Duhen,Isabelle Puisieux,Bernhard Homey,Edward P. Bowman,Giorgio Trinchieri,Bertrand Dubois,Dominique Kaiserlian,Sergio A. Lira,Alain Puisieux,Jean-Yves Blay,Christophe Caux,Nathalie Bendriss-Vermare
View Articletitled, CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues
Supplemental data
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
Therese Solstad,Simer Jit Bains,Johannes Landskron,Einar Martin Aandahl,Bernd Thiede,Kjetil Taskén,Knut Martin Torgersen
View Articletitled, CD147 (Basigin/Emmprin) identifies FoxP3<sup>+</sup>CD45RO<sup>+</sup>CTLA4<sup>+</sup>-activated human regulatory T cells
Supplemental data
Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis
Adriano Boasso,Caroline M. Royle,Spyridon Doumazos,Veronica N. Aquino,Mara Biasin,Luca Piacentini,Barbara Tavano,Dietmar Fuchs,Francesco Mazzotta,Sergio Lo Caputo,Gene M. Shearer,Mario Clerici,David R. Graham
View Articletitled, Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis
Supplemental data
Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors
Krista M. Heinonen,Juan Ruiz Vanegas,Sylvie Brochu,Jingdong Shan,Seppo J. Vainio,Claude Perreault
View Articletitled, Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors
Supplemental data

Lymphoid Neoplasia

Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study
Clinical Trials & Observations
Raouf Ben Abdelali,Vahid Asnafi,Thibaut Leguay,Nicolas Boissel,Agnès Buzyn,Patrice Chevallier,Xavier Thomas,Stephane Lepretre,Françoise Huguet,Norbert Vey,Martine Escoffre-Barbe,Emmanuelle Tavernier,Oumedaly Reman,Nathalie Fegueux,Pascal Turlure,Philippe Rousselot,Jean-Yves Cahn,Veronique Lheritier,Yves Chalandon,Marie-Christine Béné,Elizabeth Macintyre,Hervé Dombret,Norbert Ifrah,for the Group for Research on Adult Acute Lymphoblastic Leukemia
View Articletitled, Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of <em>NOTCH1/FBXW7</em> mutations, but not of low <em>ERG/BAALC</em> expression: a GRAALL study
Supplemental data
A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma
Clinical Trials & Observations
Todd A. Fehniger,Sarah Larson,Kathryn Trinkaus,Marilyn J. Siegel,Amanda F. Cashen,Kristie A. Blum,Timothy S. Fenske,David D. Hurd,Andre Goy,Stephanie E. Schneider,Catherine R. Keppel,Nina D. Wagner-Johnston,Kenneth R. Carson,Nancy L. Bartlett
View Articletitled, A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma
Supplemental data
Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study
Brief Report
William G. Wierda,Swaminathan Padmanabhan,Geoffrey W. Chan,Ira V. Gupta,Steen Lisby,Anders Österborg,for the Hx-CD20-406 Study Investigators
View Articletitled, Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study
CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
Margot Jak,Gregor G. W. van Bochove,Eric A. Reits,Wouter W. Kallemeijn,Jacqueline M. Tromp,Pablo Umana,Christian Klein,Rene A. W. van Lier,Marinus H. J. van Oers,Eric Eldering
View Articletitled, CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
Supplemental data
Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2
Xin-Yan Pei,Yun Dai,Leena E. Youssefian,Shuang Chen,Wesley W. Bodie,Yukie Takabatake,Jessica Felthousen,Jorge A. Almenara,Lora B. Kramer,Paul Dent,Steven Grant
View Articletitled, Cytokinetically quiescent (G<sub>0</sub>/G<sub>1</sub>) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2
Supplemental data
Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia
Xiao-Jie Yan,Igor Dozmorov,Wentian Li,Sophia Yancopoulos,Cristina Sison,Michael Centola,Preetesh Jain,Steven L. Allen,Jonathan E. Kolitz,Kanti R. Rai,Nicholas Chiorazzi,Barbara Sherry
View Articletitled, Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia
Supplemental data
Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups
Xin Huang,Kushi Kushekhar,Ilja Nolte,Wierd Kooistra,Lydia Visser,Ilby Bouwman,Niels Kouprie,Rianne Veenstra,Gustaaf van Imhoff,Bianca Olver,Richard S. Houlston,Sibrand Poppema,Arjan Diepstra,Bouke Hepkema,Anke van den Berg
View Articletitled, Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups
Supplemental data
Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies
Laura E. Hogan,Julia A. Meyer,Jun Yang,Jinhua Wang,Nicholas Wong,Wenjian Yang,Gregory Condos,Stephen P. Hunger,Elizabeth Raetz,Richard Saffery,Mary V. Relling,Deepa Bhojwani,Debra J. Morrison,William L. Carroll
View Articletitled, Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies
Supplemental data

Myeloid Neoplasia

EZH2 mutational status predicts poor survival in myelofibrosis
Clinical Trials & Observations
Paola Guglielmelli,Flavia Biamonte,Joannah Score,Claire Hidalgo-Curtis,Francisco Cervantes,Margherita Maffioli,Tiziana Fanelli,Thomas Ernst,Nils Winkelman,Amy V. Jones,Katerina Zoi,Andreas Reiter,Andrew Duncombe,Laura Villani,Alberto Bosi,Giovanni Barosi,Nicholas C. P. Cross,Alessandro M. Vannucchi
View Articletitled, <em>EZH2</em> mutational status predicts poor survival in myelofibrosis
Supplemental data
Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
Benjamin Mizukawa,Junping Wei,Mahesh Shrestha,Mark Wunderlich,Fu-Sheng Chou,Andrea Griesinger,Chad E. Harris,Ashish R. Kumar,Yi Zheng,David A. Williams,James C. Mulloy
View Articletitled, Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
Blood CD34−c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
Brief Report
Sophie Georgin-Lavialle,Ludovic Lhermitte,Cédric Baude,Stéphane Barete,Julie Bruneau,Jean-Marie Launay,Marie-Olivia Chandesris,Katia Hanssens,Christian de Gennes,Gandhi Damaj,Fanny Lanternier,Mohamed Hamidou,Olivier Lortholary,Patrice Dubreuil,Frédéric Feger,Yves Lepelletier,Olivier Hermine
View Articletitled, Blood CD34<sup>−</sup>c-Kit<sup>+</sup> cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Brief Report
Thomas O'Hare,Matthew S. Zabriskie,Christopher A. Eide,Anupriya Agarwal,Lauren T. Adrian,Huihong You,Amie S. Corbin,Fei Yang,Richard D. Press,Victor M. Rivera,Julie Toplin,Stephane Wong,Michael W. Deininger,Brian J. Druker
View Articletitled, The BCR-ABL<sup>35INS</sup> insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
Manjula Karpurapu,Xuerong Wang,Jing Deng,Hyesuk Park,Lei Xiao,Ruxana T. Sadikot,Randall S. Frey,Ulrich A. Maus,Gye Young Park,Edward W. Scott,John W. Christman
View Articletitled, Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
Supplemental data

Platelets and Thrombopoiesis

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera
Paul A. McEwan,Wenjun Yang,Katherine H. Carr,Xi Mo,Xiaofeng Zheng,Renhao Li,Jonas Emsley
View Articletitled, Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera
Supplemental data

Red Cells, Iron, and Erythropoiesis

Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome
Joanna F. Flatt,Hélène Guizouarn,Nicholas M. Burton,Franck Borgese,Richard J. Tomlinson,Robert J. Forsyth,Stephen A. Baldwin,Bari E. Levinson,Philippe Quittet,Patricia Aguilar-Martinez,Jean Delaunay,Gordon W. Stewart,Lesley J. Bruce
View Articletitled, Stomatin-deficient cryohydrocytosis results from mutations in <em>SLC2A1</em>: a novel form of GLUT1 deficiency syndrome
Supplemental data
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
Victor R. Gordeuk,Galina Y. Miasnikova,Adelina I. Sergueeva,Xiaomei Niu,Mehdi Nouraie,Daniel J. Okhotin,Lydia A. Polyakova,Tatiana Ammosova,Sergei Nekhai,Tomas Ganz,Josef T. Prchal
View Articletitled, Chuvash polycythemia <em>VHL<sup>R200W</sup></em> mutation is associated with down-regulation of hepcidin expression

Thrombosis and Hemostasis

Shear stress–induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region
Xiaoyun Fu,Junmei Chen,Ryan Gallagher,Ying Zheng,Dominic W. Chung,José A. López
View Articletitled, Shear stress–induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region
Supplemental data
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
Alexey S. Revenko,Dacao Gao,Jeff R. Crosby,Gourab Bhattacharjee,Chenguang Zhao,Chris May,David Gailani,Brett P. Monia,A. Robert MacLeod
View Articletitled, Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
Supplemental data
Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain
Tim Ganderton,Jason W. H. Wong,Christina Schroeder,Philip J. Hogg
View Articletitled, Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain
Supplemental data

Transplantation

Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation
Holbrook E. Kohrt,Antonia Müller,Jeanette Baker,Matthew J. Goldstein,Evan Newell,Suparna Dutt,Debra Czerwinski,Robert Lowsky,Samuel Strober
View Articletitled, Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation
Supplemental data
Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell–stimulated T cells yet preserves immunity to recall antigen
Brian C. Betts,Omar Abdel-Wahab,Shane A. Curran,Erin T. St Angelo,Priya Koppikar,Glenn Heller,Ross L. Levine,James W. Young
View Articletitled, Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell–stimulated T cells yet preserves immunity to recall antigen
Supplemental data
Anti–IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses
Brief Report
Brian C. Betts,Erin T. St Angelo,Michael Kennedy,James W. Young
View Articletitled, Anti–IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses
HLA-targeted flow cytometric sorting of blood cells allows separation of pure and viable microchimeric cell populations
e-blood
Jos J. M. Drabbels,Carin van de Keur,Berit M. Kemps,Arend Mulder,Sicco A. Scherjon,Frans H. J. Claas,Michael Eikmans
View Articletitled, HLA-targeted flow cytometric sorting of blood cells allows separation of pure and viable microchimeric cell populations

Vascular Biology

Latent KSHV infection increases the vascular permeability of human endothelial cells
Christophe Guilluy,Zhigang Zhang,Prasanna M. Bhende,Lisa Sharek,Ling Wang,Keith Burridge,Blossom Damania
View Articletitled, Latent KSHV infection increases the vascular permeability of human endothelial cells
Supplemental data
PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway
Yushan Zhang,Yehia Daaka
View Articletitled, PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway
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