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Issue Archive

Volume 117, Issue 24
June 16 2011
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Ushering in a new era for POEMS
Angela Dispenzieri
View Articletitled, Ushering in a new era for POEMS
PLATELETS & THROMBOPOIESIS
A POTEntial new gene for thrombocytopenia
Amy E. Geddis
View Articletitled, A POTEntial new gene for thrombocytopenia
TRANSPLANTATION
Chronic GVHD: a new risk score?
Gerard Socié
View Articletitled, Chronic GVHD: a new risk score?

Blood Work

Microvascular sequestration of Plasmodium falciparum
View Articletitled, Microvascular sequestration of <em>Plasmodium falciparum</em>

Perspectives

Twenty-five years of peripheral blood stem cell transplantation
Martin Körbling,Emil J Freireich
View Articletitled, Twenty-five years of peripheral blood stem cell transplantation

Review Articles

Crustacean hematopoiesis and the astakine cytokines
Xionghui Lin,Irene Söderhäll
View Articletitled, Crustacean hematopoiesis and the astakine cytokines

Clinical Trials and Observations

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia
Clinical Trials & Observations
Sai-Juan Chen,Guang-Biao Zhou,Xiao-Wei Zhang,Jian-Hua Mao,Hugues de Thé,Zhu Chen
View Articletitled, From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

Gene Therapy

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver
Ashley T. Martino,Masataka Suzuki,David M. Markusic,Irene Zolotukhin,Renee C. Ryals,Babak Moghimi,Hildegund C. J. Ertl,Daniel A. Muruve,Brendan Lee,Roland W. Herzog
View Articletitled, The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver
Supplemental data
IL-7 receptor expression identifies suicide gene–modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors
Attilio Bondanza,Lothar Hambach,Zohara Aghai,Bart Nijmeijer,Shin Kaneko,Sara Mastaglio,Marina Radrizzani,Katharina Fleischhauer,Fabio Ciceri,Claudio Bordignon,Chiara Bonini,Els Goulmy
View Articletitled, IL-7 receptor expression identifies suicide gene–modified allospecific CD8<sup>+</sup> T cells capable of self-renewal and differentiation into antileukemia effectors
Supplemental data

Hematopoiesis and Stem Cells

TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs
Lara Rossi,Aysegul V. Ergen,Margaret A. Goodell
View Articletitled, TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs
Supplemental data
The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
Sonia Rodriguez,Lin Wang,Christen Mumaw,Edward F. Srour,Cristina Lo Celso,Kei-ichi Nakayama,Nadia Carlesso
View Articletitled, The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
Supplemental data
Galectin-1–expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow
Frédéric Mourcin,Caroline Breton,Julie Tellier,Priyanka Narang,Lionel Chasson,Audrey Jorquera,Mark Coles,Claudine Schiff,Stéphane J. C. Mancini
View Articletitled, Galectin-1–expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow
Supplemental data

Immunobiology

Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ
Elzbieta Janda,Camillo Palmieri,Antonio Pisano,Marilena Pontoriero,Enrico Iaccino,Cristina Falcone,Giuseppe Fiume,Marco Gaspari,Maria Nevolo,Emanuela Di Salle,Annalisa Rossi,Annamaria De Laurentiis,Adelaide Greco,Daniele Di Napoli,Elwin Verheij,Domenico Britti,Luca Lavecchia,Ileana Quinto,Giuseppe Scala
View Articletitled, Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ
Supplemental data
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
Bastian Hoechst,Jaba Gamrekelashvili,Michael P. Manns,Tim F. Greten,Firouzeh Korangy
View Articletitled, Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
Supplemental data
Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28
Jeffrey S. Pufnock,Melinda Cigal,Lisa S. Rolczynski,Erica Andersen-Nissen,Mathias Wolfl,M. Juliana McElrath,Philip D. Greenberg
View Articletitled, Priming CD8<sup>+</sup> T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8<sup>+</sup> T cells retaining CD28
Identification of CCR9− murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs
Andreas Schlitzer,Jakob Loschko,Katrin Mair,Roger Vogelmann,Lynette Henkel,Henrik Einwächter,Matthias Schiemann,Jan-Hendrik Niess,Wolfgang Reindl,Anne Krug
View Articletitled, Identification of CCR9<sup>−</sup> murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs
Supplemental data
NKG2D receptor regulates human effector T-cell cytokine production
Amorette Barber,Charles L. Sentman
View Articletitled, NKG2D receptor regulates human effector T-cell cytokine production
Supplemental data
Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
Philippe Krebs,Karine Crozat,Daniel Popkin,Michael B. Oldstone,Bruce Beutler
View Articletitled, Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
Supplemental data
DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway
Alexandra A. Lambert,Frédéric Barabé,Caroline Gilbert,Michel J. Tremblay
View Articletitled, DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway
Inhibition of β-TrcP–dependent ubiquitination of p53 by HIV-1 Vpu promotes p53–mediated apoptosis in human T cells
Sachin Verma,Amjad Ali,Sakshi Arora,Akhil C. Banerjea
View Articletitled, Inhibition of β-TrcP–dependent ubiquitination of p53 by HIV-1 Vpu promotes p53–mediated apoptosis in human T cells
Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells
Brief Report
Marsilio Adriani,Krysten A. Jones,Toru Uchiyama,Martha R. Kirby,Christopher Silvin,Stacie M. Anderson,Fabio Candotti
View Articletitled, Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells
Supplemental data

Lymphoid Neoplasia

Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients
Clinical Trials & Observations
Linda N. Dao,Curtis A. Hanson,Angela Dispenzieri,William G. Morice,Paul J. Kurtin,James D. Hoyer
View Articletitled, Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients
Combination of melphalan and dexamethasone for patients with newly diagnosed POEMS syndrome
Clinical Trials & Observations
Jian Li,Wei Zhang,Li Jiao,Ming-Hui Duan,Hong-Zhi Guan,Wei-Guo Zhu,Zhuang Tian,Dao-Bin Zhou
View Articletitled, Combination of melphalan and dexamethasone for patients with newly diagnosed POEMS syndrome
Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
Clinical Trials & Observations
William G. Wierda,Thomas J. Kipps,Jan Dürig,Laimonas Griskevicius,Stephan Stilgenbauer,Jiří Mayer,Lukáš Smolej,Georg Hess,Rasa Griniute,Francisco J. Hernandez-Ilizaliturri,Swaminathan Padmanabhan,Michele Gorczyca,Chai-Ni Chang,Geoffrey Chan,Ira Gupta,Tina G. Nielsen,Charlotte A. Russell,on behalf of the 407 Study Investigators
View Articletitled, Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
Supplemental data
Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma
Fabio Munari,Silvia Lonardi,Marco A. Cassatella,Claudio Doglioni,Maria Giulia Cangi,Amedeo Amedei,Fabio Facchetti,Yoshinobu Eishi,Massimo Rugge,Matteo Fassan,Marina de Bernard,Mario M. D'Elios,William Vermi
View Articletitled, Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
Paola Martinelli,Paola Bonetti,Cristina Sironi,Giancarlo Pruneri,Caterina Fumagalli,Paola Rafaniello Raviele,Sara Volorio,Stefano Pileri,Roberto Chiarle,Fiona Kate Elizabeth McDuff,Betsabeh Khoramian Tusi,Suzanne D. Turner,Giorgio Inghirami,Pier Giuseppe Pelicci,Emanuela Colombo
View Articletitled, The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
Supplemental data
MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression
Cécile Desjobert,Marie-Hélène Renalier,Julie Bergalet,Emilie Dejean,Nicole Joseph,Anna Kruczynski,Jean Soulier,Estelle Espinos,Fabienne Meggetto,Jérome Cavaillé,Georges Delsol,Laurence Lamant
View Articletitled, MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression
Supplemental data
Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma
Peter Kamper,Maja Ludvigsen,Knud Bendix,Stephen Hamilton-Dutoit,Gabriel A. Rabinovich,Michael Boe Møller,Jens R. Nyengaard,Bent Honoré,Francesco d'Amore
View Articletitled, Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma
Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia
Mélanie Bonnet,Marie Loosveld,Bertrand Montpellier,Jean-Marc Navarro,Benoit Quilichini,Christophe Picard,Julie Di Cristofaro,Claude Bagnis,Chantal Fossat,Lucie Hernandez,Emilie Mamessier,Sandrine Roulland,Ester Morgado,Christine Formisano-Tréziny,Willem A. Dik,Anton W. Langerak,Thomas Prebet,Norbert Vey,Gérard Michel,Jean Gabert,Jean Soulier,Elizabeth A. Macintyre,Vahid Asnafi,Dominique Payet-Bornet,Bertrand Nadel
View Articletitled, Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia
Supplemental data

Myeloid Neoplasia

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
Clinical Trials & Observations
Claire M. Lucas,Robert J. Harris,Athina Giannoudis,Mhairi Copland,Joseph R. Slupsky,Richard E. Clark
View Articletitled, Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
Supplemental data
Recombinant interferon-α may retard progression of early primary myelofibrosis: a preliminary report
Brief Report
Richard T. Silver,Katherine Vandris,Joshua J. Goldman
View Articletitled, Recombinant interferon-α may retard progression of early primary myelofibrosis: a preliminary report

Phagocytes, Granulocytes, and Myelopoiesis

RUNX1 regulates corepressor interactions of PU.1
Zhenbo Hu,Xiaorong Gu,Kristine Baraoidan,Vinzon Ibanez,Arun Sharma,ShriHari Kadkol,Reinhold Munker,Steven Ackerman,Giuseppina Nucifora,Yogen Saunthararajah
View Articletitled, RUNX1 regulates corepressor interactions of PU.1
Supplemental data

Platelets and Thrombopoiesis

Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families
Patrizia Noris,Silverio Perrotta,Marco Seri,Alessandro Pecci,Chiara Gnan,Giuseppe Loffredo,Nuria Pujol-Moix,Marco Zecca,Francesca Scognamiglio,Daniela De Rocco,Francesca Punzo,Federica Melazzini,Saverio Scianguetta,Maddalena Casale,Caterina Marconi,Tommaso Pippucci,Giovanni Amendola,Lucia D. Notarangelo,Catherine Klersy,Elisa Civaschi,Carlo L. Balduini,Anna Savoia
View Articletitled, Mutations in <em>ANKRD26</em> are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families

Red Cells, Iron, and Erythropoiesis

Genetic predictors for stroke in children with sickle cell anemia
Brief Report
Jonathan M. Flanagan,Denise M. Frohlich,Thad A. Howard,William H. Schultz,Catherine Driscoll,Ramamoorthy Nagasubramanian,Nicole A. Mortier,Amy C. Kimble,Banu Aygun,Robert J. Adams,Ronald W. Helms,Russell E. Ware
View Articletitled, Genetic predictors for stroke in children with sickle cell anemia

Thrombosis and Hemostasis

Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue
Josefin Ahnström,Helena M. Andersson,Kevin Canis,Eva Norstrøm,Yao Yu,Björn Dahlbäck,Maria Panico,Howard R. Morris,James T. B. Crawley,David A. Lane
View Articletitled, Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue
Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction
Shirley Uitte de Willige,Megan Miedzak,Angela M. Carter,Ton Lisman,Frits R. Rosendaal,Peter J. Grant,Helen Philippou,Robert A. S. Ariëns
View Articletitled, Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction

Transfusion Medicine

Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model
Yitang Li,Amit Prasad,Yonghui Jia,Saurabh Ghosh Roy,Fabien Loison,Subhanjan Mondal,Paulina Kocjan,Leslie E. Silberstein,Sheng Ding,Hongbo R. Luo
View Articletitled, Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model
Supplemental data

Transplantation

Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis
Clinical Trials & Observations
Mukta Arora,John P. Klein,Daniel J. Weisdorf,Anna Hassebroek,Mary E. D. Flowers,Corey S. Cutler,Alvaro Urbano-Ispizua,Joseph H. Antin,Brian J. Bolwell,Michael Boyiadzis,Jean-Yves Cahn,Mitchell S. Cairo,Luis Isola,David A. Jacobsohn,Madan Jagasia,Thomas R. Klumpp,Stephanie J. Lee,Effie W. Petersdorf,Stella Santarone,Robert Peter Gale,Harry C. Schouten,Stephen Spellman,John R. Wingard,Mary M. Horowitz,Steven Z. Pavletic
View Articletitled, Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis
Long-term follow-up of a comparison of nonmyeloablative allografting with autografting for newly diagnosed myeloma
Clinical Trials & Observations
Luisa Giaccone,Barry Storer,Francesca Patriarca,Marcello Rotta,Roberto Sorasio,Bernardino Allione,Fabrizio Carnevale-Schianca,Moreno Festuccia,Lucia Brunello,Paola Omedè,Sara Bringhen,Massimo Aglietta,Alessandro Levis,Nicola Mordini,Andrea Gallamini,Renato Fanin,Massimo Massaia,Antonio Palumbo,Giovannino Ciccone,Rainer Storb,Ted A. Gooley,Mario Boccadoro,Benedetto Bruno
View Articletitled, Long-term follow-up of a comparison of nonmyeloablative allografting with autografting for newly diagnosed myeloma

Vascular Biology

Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment
Brandoch D. Cook,Susanna Liu,Todd Evans
View Articletitled, <em>Smad1</em> signaling restricts hematopoietic potential after promoting hemangioblast commitment
Supplemental data
The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow
Ivan B. Lobov,Eunice Cheung,Rajeev Wudali,Jingtai Cao,Gabor Halasz,Yi Wei,Aris Economides,Hsin C. Lin,Nicholas Papadopoulos,George D. Yancopoulos,Stanley J. Wiegand
View Articletitled, The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow
Supplemental data

Errata

Nichol D, Shawber C, Fitch MJ, et al. Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood. 2010;116(26):6133–6143.
View Articletitled, Nichol D, Shawber C, Fitch MJ, et al. Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. <em>Blood</em>. 2010;116(26):<span class="related-article">6133–6143</span>.
Demarest RM, Dahmane N, Capobianco AJ. Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia. Blood. 2011;117(10):2901–2909.
View Articletitled, Demarest RM, Dahmane N, Capobianco AJ. Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia. <em>Blood</em>. 2011;117(10):<span class="related-article">2901–2909</span>.
Li H, Malani N, Hamilton SR, et al. Assessing the potential for AAV vector genotoxicity in a murine model. Blood. 2011;117(12):3311–3319.
View Articletitled, Li H, Malani N, Hamilton SR, et al. Assessing the potential for AAV vector genotoxicity in a murine model. <em>Blood</em>. 2011;117(12):<span class="related-article">3311–3319</span>.

Retraction

Elsheikh E, Uzunel M, He Z, Holgersson J, Nowak G, Sumitran-Holgersson S. Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity. Blood. 2005;106(7):2347–2355.
View Articletitled, Elsheikh E, Uzunel M, He Z, Holgersson J, Nowak G, Sumitran-Holgersson S. Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity. <em>Blood.</em> 2005;106(7):<span class="related-article">2347–2355</span>.
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