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Issue Archive

Volume 117, Issue 22
June 2 2011
Blood Cover Image for Volume 117, Issue 22

Table of Contents

Inside Blood

VASCULAR BIOLOGY
Sema 3A resists retinal revascularization
Elia J. Duh
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CLINICAL TRIALS
For disease in need, a Friend indeed
Owen A. O'Connor
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HEMATOPOIESIS & STEM CELLS
“Let”-ing go with clonal expansion?
Linda M. Resar,Robert A. Brodsky
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INSIDE BLOOD
When differentiation goes viral
Courtney M. Shirley,Richard F. Ambinder
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PLATELETS & THROMBOPOIESIS
Megakaryocyte TLR2: immunity bullet?
Pasquale Pignatelli,Roberto Carnevale
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Blood Work

Refractory anemia with ring sideroblasts masked by iron deficiency anemia
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Perspectives

Revisiting the differentiation paradigm in acute promyelocytic leukemia
Julien Ablain,Hugues de The
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Review Articles

Malignant hematologic diseases in adolescents and young adults
Clinical Trials & Observations
William A. Wood,Stephanie J. Lee
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Do reactive oxygen species play a role in myeloid leukemias?
Paul Spencer Hole,Richard Lawrence Darley,Alex Tonks
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Hematopoiesis and Stem Cells

3′UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice
Kazuhiko Ikeda,Philip J. Mason,Monica Bessler
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Supplemental data
Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation
Ronan Quéré,Göran Karlsson,Falk Hertwig,Marianne Rissler,Beata Lindqvist,Thoas Fioretos,Peter Vandenberghe,Marilyn L. Slovak,Jörg Cammenga,Stefan Karlsson
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Supplemental data

Immunobiology

Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
Clinical Trials & Observations
Jeffrey I. Cohen,Elaine S. Jaffe,Janet K. Dale,Stefania Pittaluga,Helen E. Heslop,Cliona M. Rooney,Stephen Gottschalk,Catherine M. Bollard,V. Koneti Rao,Adriana Marques,Peter D. Burbelo,Siu-Ping Turk,Rachael Fulton,Alan S. Wayne,Richard F. Little,Mitchell S. Cairo,Nader K. El-Mallawany,Daniel Fowler,Claude Sportes,Michael R. Bishop,Wyndham Wilson,Stephen E. Straus
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Supplemental data
CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection
Rodolfo Silva,Susan Moir,Lela Kardava,Karen Debell,Venkateswara R. Simhadri,Sara Ferrando-Martínez,Manuel Leal,José Peña,John E. Coligan,Francisco Borrego
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Supplemental data
Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans
Claudia Stuehler,Nina Khanna,Silvia Bozza,Teresa Zelante,Silvia Moretti,Michaela Kruhm,Sarah Lurati,Barbara Conrad,Eike Worschech,Stefan Stevanović,Sven Krappmann,Hermann Einsele,Jean-Paul Latgé,Juergen Loeffler,Luigina Romani,Max S. Topp
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Supplemental data
Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations
Brief Report
Taco W. Kuijpers,Hanna IJspeert,Ester M. M. van Leeuwen,Machiel H. Jansen,Mette D. Hazenberg,Kees C. Weijer,Rene A. W. van Lier,Mirjam van der Burg
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Supplemental data

Lymphoid Neoplasia

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
Clinical Trials & Observations
Richard L. Piekarz,Robin Frye,H. Miles Prince,Mark H. Kirschbaum,Jasmine Zain,Steven L. Allen,Elaine S. Jaffe,Alexander Ling,Maria Turner,Cody J. Peer,William D. Figg,Seth M. Steinberg,Sonali Smith,David Joske,Ian Lewis,Laura Hutchins,Michael Craig,A. Tito Fojo,John J. Wright,Susan E. Bates
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Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair
Hicham H. Baydoun,Joanna Pancewicz,Christophe Nicot
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Down-regulation of BLIMP1α by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas
Katerina Vrzalikova,Martina Vockerodt,Sarah Leonard,Andrew Bell,Wenbin Wei,Alexandra Schrader,Kenneth L. Wright,Dieter Kube,Martin Rowe,Ciaran B. Woodman,Paul G. Murray
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Supplemental data

Myeloid Neoplasia

Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML
Simon Haefliger,Christiane Klebig,Kerstin Schaubitzer,Julian Schardt,Nikolai Timchenko,Beatrice U. Mueller,Thomas Pabst
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Supplemental data
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A
Arelis Salas,Suriyan Ponnusamy,Can E. Senkal,Marisa Meyers-Needham,Shanmugam Panneer Selvam,Sahar A. Saddoughi,Elif Apohan,R. David Sentelle,Charles Smith,Christopher R. Gault,Lina M. Obeid,Hesham M. El-Shewy,Joshua Oaks,Ramasamy Santhanam,Guido Marcucci,Yusuf Baran,Sandeep Mahajan,Daniel Fernandes,Robert Stuart,Danilo Perrotti,Besim Ogretmen
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Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils
Barbara Geering,Ursina Gurzeler,Elena Federzoni,Thomas Kaufmann,Hans-Uwe Simon
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Platelets and Thrombopoiesis

Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients
Brief Report
Alessandra Carobbio,Juergen Thiele,Francesco Passamonti,Elisa Rumi,Marco Ruggeri,Francesco Rodeghiero,Maria Luigia Randi,Irene Bertozzi,Alessandro M. Vannucchi,Elisabetta Antonioli,Heinz Gisslinger,Veronika Buxhofer-Ausch,Guido Finazzi,Naseema Gangat,Ayalew Tefferi,Tiziano Barbui
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Supplemental data
Regulatory effects of TLR2 on megakaryocytic cell function
Lea M. Beaulieu,Elaine Lin,Kristine M. Morin,Kahraman Tanriverdi,Jane E. Freedman
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Supplemental data
Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro
José Perdomo,Feng Yan,Zohra Ahmadi,Xing-Mai Jiang,Roland Stocker,Beng H. Chong
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Supplemental data

Red Cells, Iron, and Erythropoiesis

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
Elizabeth R. Macari,Christopher H. Lowrey
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Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3
Emanuela Ferru,Katie Giger,Antonella Pantaleo,Estela Campanella,Jesse Grey,Ken Ritchie,Rosa Vono,Francesco Turrini,Philip S. Low
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Supplemental data

Thrombosis and Hemostasis

Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis
Clinical Trials & Observations
Nicholas L. Smith,Kenneth M. Rice,Edwin G. Bovill,Mary Cushman,Joshua C. Bis,Barbara McKnight,Thomas Lumley,Nicole L. Glazer,Astrid van Hylckama Vlieg,Weihong Tang,Abbas Dehghan,David P. Strachan,Christopher J. O'Donnell,Jerome I. Rotter,Susan R. Heckbert,Bruce M. Psaty,Frits R. Rosendaal
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Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation
Cathy Paddock,Betsy L. Lytle,Francis C. Peterson,Trudy Holyst,Peter J. Newman,Brian F. Volkman,Debra K. Newman
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Supplemental data

Transplantation

Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation
Clinical Trials & Observations
Stefan Schwartz,Maria Vergoulidou,Eckart Schreier,Christoph Loddenkemper,Mark Reinwald,Martin Schmidt-Hieber,Willy A. Flegel,Eckhard Thiel,Thomas Schneider
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Vascular Biology

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A
Jean-Sébastien Joyal,Nicholas Sitaras,François Binet,Jose Carlos Rivera,Andreas Stahl,Karine Zaniolo,Zhuo Shao,Anna Polosa,Tang Zhu,David Hamel,Mikheil Djavari,Dario Kunik,Jean-Claude Honoré,Emilie Picard,Alexandra Zabeida,Daya R. Varma,Gilles Hickson,Joseph Mancini,Michael Klagsbrun,Santiago Costantino,Christian Beauséjour,Pierre Lachapelle,Lois E. H. Smith,Sylvain Chemtob,Przemyslaw Sapieha
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Supplemental data
Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1–dependent signaling pathway
Bin Ren,James Hale,Sowmya Srikanthan,Roy L. Silverstein
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Correspondence

A novel mechanism of transplacental cancer transmission: natural killer/T-cell lymphoma in the paratesticular region is of maternal origin
Hiroshi Yagasaki,Haruhiko Ohashi,Masahumi Ito,Sumiko Kobayashi,Maiko Kato,Hiroyuki Shichino,Motoaki Chin,Hideo Mugishima
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Supplemental data
Fanconi anemia (FA)–associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA
Stefan Meyer,Claire Bristow,Mark Wappett,Stuart Pepper,Anthony D. Whetton,Helmut Hanenberg,Heidemarie Neitzel,Marcin W. Wlodarski,Wolfram Ebell,Holger Tönnies
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Supplemental data
Doubts concerning the recently reported human neutrophil lifespan of 5.4 days
Paul S. Tofts,Timothy Chevassut,Marica Cutajar,Nicholas G. Dowell,A. Michael Peters
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Deuterium and neutrophil kinetics
Kelvin W. Li,Scott M. Turner,Claire L. Emson,Marc K. Hellerstein,David C. Dale
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Response: The in vivo half-life of human neutrophils
Janesh Pillay,Ineke den Braber,Nienke Vrisekoop,Lydia M. Kwast,Rob J. de Boer,Jose A. M. Borghans,Kiki Tesselaar,Leo Koenderman
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Anemia in congenital nephrotic syndrome: role of urinary copper and ceruloplasmin loss
Olivier Niel,Marie-Christine Thouret,Etienne Bérard
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All Issues

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