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Inside blood

HEMATOPOIESIS & STEM CELLS
CLINICAL TRIALS
IMMUNOBIOLOGY
INSIDE BLOOD
TRANSFUSION MEDICINE
VASCULAR BIOLOGY

Review Article

Clinical Trials and Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Thrombosis and Hemostasis

Transfusion Medicine

Transplantation

Vascular Biology

  • Cover Image

    Cover Image

    issue cover

    The structure of IRS-2. The picture shows the overall 3-dimensional structure of IRS-2, which is the first example of a parasitic serpin. IRS-2 expression is up-regulated in tick salivary glands upon attachment to the vertebrate host, and the protein inhibits host platelet aggregation and acute inflammation. IRS-2 targets specifically human cathepsin G and chymase, which is a novel mechanism of action for an exogenous protein. The molecular, cellular, and structural aspects of IRS-2 interference with the host defense mechanisms, as well as its potential future pharmaceutical applications, are detailed in the article by Chmelar et al on page 736.

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