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Thrombopoietin production in murine bone marrow in response to systemic G-CSF. The cover image shows staining of bone marrow sections from C57/BL6 mice 2 hours after intravenous injection of recombinant human G-CSF. The blue color shows cell nuclei, while the brown color shows the production of thrombopoietin. The light brown cell with large, multilobular nuclei is a megakaryocyte (MGK). Please note the punctate, intense brown color in cells from G-CSF–treated mice, which are close to the MGK. This result shows a very rapid production of thrombopoietin in response to systemic G-CSF, which can trigger the secretion of CXCR2 ligands from MGK that, in turn, induce increased motility of neutrophils in the bone marrow. See the article by Köhler et al on page 4349.