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The cover image shows the interdependence of pulmonary angioproliferative remodeling and a bone marrow myeloproliferative process in pulmonary arterial hypertension. Hypoxia-induced factors that are released by the lung endothelium promote proliferation and mobilization of bone marrow progenitors and myelofibrosis. Likewise, myeloid progenitors recruited into the lung fuel the proliferative angiopathy. The cover image is a montage of the myelopulmonary model superimposed on histopathology of bone marrow tissue section stained for reticulin (in black) from a patient with primary pulmonary hypertension. See the article by Farha et al on page 3485.