Table of Contents
In this issue of Blood, Kreutzman and colleagues describe the existence of clonal cytotoxic T and NK cells in over 80% (15 of 18) of patients with CML at diagnosis which persisted during treatment with the tyrosine kinase inhibitors, imatinib and dasatinib.1 Furthermore, they discovered that this clonal lymphocytosis expands further after therapy with dasatinib but not imatinib.
In this issue of Blood, Richardson et al report on a landmark treatment regimen for newly diagnosed myeloma patients that for the first time combines lenalidomide and bortezomib. This effort required a team approach comprising 2 competing pharmaceutical companies (joining forces to study this promising regimen) and multiple academic medical centers.1
Warfarin and other vitamin K antagonists are very effective for the treatment and prevention of both arterial and venous thromboembolism. Recombinant factor VIIa may not be as effective as previously thought for the urgent reversal of warfarin.
In this issue of Blood, Pawlinski and colleagues identify myeloid cells and an unidentified nonhematopoietic cell(s) as the source of TF responsible for intravascular coagulation in a mouse model of endotoxemia, excluding a role for EC, VSMC, and platelet cell TF expression.1
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
Clinical Trials and Observations
Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Hematopoiesis and Stem Cells
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates
Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group
Clinical Trials & Observations
Platelets and Thrombopoiesis
Thrombosis and Hemostasis
The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non–mast cell lineage disease (SM-AHNMD)
Angiogenesis is a physiologic process involving the growth of new blood vessels from preexisting ones. Angiogenesis is fundamental for organ growth, development, and wound healing, but is also associated with different diseases, such as cancer and retinopathy. This image represents a 3-dimensional reconstruction of a tissue macrophage interacting with a growing blood vessel in the brain. Michelangelo's masterpiece, shown in the background, depicts God's plan of creation, which is realized when God's finger extends toward Adam's hand. In a visually similar manner, the macrophage, labeled in green by a specific antibody, seems to contact a filopodial extension from the blood vessel, which is labeled in red with a lectin stain. See the article by Fantin et al on page 829.
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