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Issue Archive

Volume 116, Issue 25
December 16 2010
Issue Cover

Table of Contents

Inside blood

IMMUNOBIOLOGY
AIDS-related BL and CD4 count: a clue?
Sonali M. Smith
View Articletitled, AIDS-related BL and CD4 count: a clue?
INSIDE BLOOD
“Cryptic” Notch1 messages induce T-ALL
Cynthia Guidos
View Articletitled, “Cryptic” Notch1 messages induce T-ALL
PLATELETS & THROMBOPOIESIS
Notch: of mice and men?
Sebastien Malinge,John Crispino
View Articletitled, Notch: of mice and men?
THROMBOSIS & HEMOSTASIS
LDL receptor polymorphisms revisited
Niels Bovenschen
View Articletitled, LDL receptor polymorphisms revisited
TRANSPLANTATION
Exploiting arginase to prevent GVHD
William Hallett,Bryon Johnson
View Articletitled, Exploiting arginase to prevent GVHD

Plenary paper

PLENARY PAPER
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
Robin Jeannet,Jérôme Mastio,Alejandra Macias-Garcia,Attila Oravecz,Todd Ashworth,Anne-Solen Geimer Le Lay,Bernard Jost,Stéphanie Le Gras,Jacques Ghysdael,Thomas Gridley,Tasuku Honjo,Freddy Radtke,Jon C. Aster,Susan Chan,Philippe Kastner
View Articletitled, Oncogenic activation of the <em>Notch1</em> gene by deletion of its promoter in Ikaros-deficient T-ALL
Supplemental data
PLENARY PAPER
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1
Todd D. Ashworth,Warren S. Pear,Mark Y. Chiang,Stephen C. Blacklow,Jérôme Mastio,Lanwei Xu,Michelle Kelliher,Philippe Kastner,Susan Chan,Jon C. Aster
View Articletitled, Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in <em>Notch1</em>
Supplemental data

Review Article

Polycomb proteins in hematologic malignancies
Daniel Martin-Perez,Miguel A. Piris,Margarita Sanchez-Beato
View Articletitled, Polycomb proteins in hematologic malignancies

How I treat

How I treat adenovirus in hematopoietic stem cell transplant recipients
Caroline A. Lindemans,Ann M. Leen,Jaap Jan Boelens
View Articletitled, How I treat adenovirus in hematopoietic stem cell transplant recipients

Clinical Trials and Observations

IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
Clinical Trials & Observations
Susanne Schnittger,Claudia Haferlach,Madlen Ulke,Tamara Alpermann,Wolfgang Kern,Torsten Haferlach
View Articletitled, <em>IDH1</em> mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated <em>NPM1</em> status
Efficacy of tyrosine kinase inhibitors (TKIs) as third-line therapy in patients with chronic myeloid leukemia in chronic phase who have failed 2 prior lines of TKI therapy
Clinical Trials & Observations
Amr R. Ibrahim,Christos Paliompeis,Marco Bua,Dragana Milojkovic,Richard Szydlo,Jamshid S. Khorashad,Letizia Foroni,Alistair Reid,Hugues de Lavallade,Katayoun Rezvani,Francesco Dazzi,Jane F. Apperley,John M. Goldman,David Marin
View Articletitled, Efficacy of tyrosine kinase inhibitors (TKIs) as third-line therapy in patients with chronic myeloid leukemia in chronic phase who have failed 2 prior lines of TKI therapy
Racial disparities in incidence and outcome in multiple myeloma: a population-based study
Clinical Trials & Observations
Adam J. Waxman,Pamela J. Mink,Susan S. Devesa,William F. Anderson,Brendan M. Weiss,Sigurdur Y. Kristinsson,Katherine A. McGlynn,Ola Landgren
View Articletitled, Racial disparities in incidence and outcome in multiple myeloma: a population-based study
AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology?
Clinical Trials & Observations
Mercy Guech-Ongey,Edgar P. Simard,William F. Anderson,Eric A. Engels,Kishor Bhatia,Susan S. Devesa,Sam M. Mbulaiteye
View Articletitled, AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology?
Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group
Clinical Trials & Observations
Martin S. Tallman,Haesook T. Kim,Pau Montesinos,Frederick R. Appelbaum,Javier de la Serna,John M. Bennett,Guillermo Deben,Clara D. Bloomfield,Jose Gonzalez,James H. Feusner,Marcos Gonzalez,Robert Gallagher,Jose D. Gonzalez-San Miguel,Richard A. Larson,Gustavo Milone,Elisabeth Paietta,Chelo Rayon,Jacob M. Rowe,Concha Rivas,Charles A. Schiffer,Edo Vellenga,Lois Shepherd,James L. Slack,Peter H. Wiernik,Cheryl L. Willman,Miguel A. Sanz
View Articletitled, Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group
BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Clinical Trials & Observations
Sebastian Schwind,Guido Marcucci,Kati Maharry,Michael D. Radmacher,Krzysztof Mrózek,Kelsi B. Holland,Dean Margeson,Heiko Becker,Susan P. Whitman,Yue-Zhong Wu,Klaus H. Metzeler,Bayard L. Powell,Jonathan E. Kolitz,Thomas H. Carter,Joseph O. Moore,Maria R. Baer,Andrew J. Carroll,Michael A. Caligiuri,Richard A. Larson,Clara D. Bloomfield
View Articletitled, <em>BAALC</em> and <em>ERG</em> expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Supplemental data

Gene therapy

High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors
Claudia Cattoglio,Danilo Pellin,Ermanno Rizzi,Giulietta Maruggi,Giorgio Corti,Francesca Miselli,Daniela Sartori,Alessandro Guffanti,Clelia Di Serio,Alessandro Ambrosi,Gianluca De Bellis,Fulvio Mavilio
View Articletitled, High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors
Supplemental data

Hematopoiesis and Stem Cells

Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation
Congxiao Liu,Benny J. Chen,Divinomar DeOliveira,Gregory D. Sempowski,Nelson J. Chao,Robert W. Storms
View Articletitled, Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation
Supplemental data
Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche
Yuriko Kawamori,Yoshio Katayama,Noboru Asada,Kentaro Minagawa,Mari Sato,Atsuo Okamura,Manabu Shimoyama,Kimie Nakagawa,Toshio Okano,Mitsune Tanimoto,Shigeaki Kato,Toshimitsu Matsui
View Articletitled, Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche
Supplemental data

Immunobiology

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes
Mustapha Faroudi,Miroslav Hons,Agnieszka Zachacz,Celine Dumont,Ruth Lyck,Jens V. Stein,Victor L. J. Tybulewicz
View Articletitled, Critical roles for Rac GTPases in T-cell migration to and within lymph nodes
Supplemental data
T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool
Jennifer E. Smith-Garvin,Jeremy C. Burns,Mercy Gohil,Tao Zou,Jiyeon S. Kim,Jonathan S. Maltzman,E. John Wherry,Gary A. Koretzky,Martha S. Jordan
View Articletitled, T-cell receptor signals direct the composition and function of the memory CD8<sup>+</sup> T-cell pool
Supplemental data
Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells
Karla R. Wiehagen,Evann Corbo,Michelle Schmidt,Haina Shin,E. John Wherry,Jonathan S. Maltzman
View Articletitled, Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8<sup>+</sup> memory T cells
Supplemental data
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
Susan Moir,Clarisa M. Buckner,Jason Ho,Wei Wang,Jenny Chen,Amy J. Waldner,Jacqueline G. Posada,Lela Kardava,Marie A. O'Shea,Shyam Kottilil,Tae-Wook Chun,Michael A. Proschan,Anthony S. Fauci
View Articletitled, B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
Supplemental data
Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation
Fui G. Goh,Scott J. P. Thomson,Thomas Krausgruber,Alessandra Lanfrancotti,Richard R. Copley,Irina A. Udalova
View Articletitled, Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation
Supplemental data
Interleukin-7 treatment counteracts IFN-α therapy-induced lymphopenia and stimulates SIV-specific cytotoxic T lymphocyte responses in SIV-infected rhesus macaques
Raphaëlle Parker,Jacques Dutrieux,Stéphanie Beq,Brigitte Lemercier,Sandra Rozlan,Véronique Fabre-Mersseman,Magali Rancez,Céline Gommet,Brigitte Assouline,Iann Rancé,Annick Lim,Michel Morre,Rémi Cheynier
View Articletitled, Interleukin-7 treatment counteracts IFN-α therapy-induced lymphopenia and stimulates SIV-specific cytotoxic T lymphocyte responses in SIV-infected rhesus macaques
Supplemental data
Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation
Kengo Takeuchi,Masahiro Yokoyama,Shin Ishizawa,Yasuhito Terui,Kimie Nomura,Kousuke Marutsuka,Maki Nunomura,Noriyasu Fukushima,Takahiro Yagyuu,Hirokazu Nakamine,Futoshi Akiyama,Kazuei Hoshi,Kosei Matsue,Kiyohiko Hatake,Kazuo Oshimi
View Articletitled, Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation

Lymphoid Neoplasia

Distinct molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells
Scott H. Olejniczak,Jennifer Blickwedehl,Alan Belicha-Villanueva,Naveen Bangia,Wasif Riaz,Cory Mavis,James L. Clements,John Gibbs,Francisco J. Hernandez-Ilizaliturri,Myron S. Czuczman
View Articletitled, Distinct molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells
Mutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in mice
Jun Li,Takashi Maruyama,Pin Zhang,Joanne E. Konkel,Victoria Hoffman,Brian Zamarron,WanJun Chen
View Articletitled, Mutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in mice
Supplemental data
8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma
Jennifer B. Dennison,Mala Shanmugam,Mary L. Ayres,Jun Qian,Nancy L. Krett,L. Jeffrey Medeiros,Sattva S. Neelapu,Steven T. Rosen,Varsha Gandhi
View Articletitled, 8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
John A. Pulikkan,Philomina S. Peramangalam,Viola Dengler,Phoenix A. Ho,Claude Preudhomme,Soheil Meshinchi,Maximilian Christopeit,Oliver Nibourel,Carsten Müller-Tidow,Stefan K. Bohlander,Daniel G. Tenen,Gerhard Behre
View Articletitled, C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with <em>CEBPA</em> mutations
Supplemental data

Platelets and Thrombopoiesis

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
Sonia Poirault-Chassac,Emmanuelle Six,Cyril Catelain,Mélanie Lavergne,Jean-Luc Villeval,William Vainchenker,Evelyne Lauret
View Articletitled, Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
Supplemental data

Red Cells, Iron, and Erythropoiesis

Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin
Paul J. Schmidt,Nancy C. Andrews,Mark D. Fleming
View Articletitled, Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin
Supplemental data
Sequence variation at multiple loci influences red cell hemoglobin concentration
e-blood
Luanne L. Peters,Jordan A. Shavit,Amy J. Lambert,Shirng-Wern Tsaih,Qian Li,Zhiguang Su,Magalie S. Leduc,Beverly Paigen,Gary A. Churchill,David Ginsburg,Carlo Brugnara
View Articletitled, Sequence variation at multiple loci influences red cell hemoglobin concentration
Supplemental data

Thrombosis and Hemostasis

Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
Nicola Martinelli,Domenico Girelli,Barbara Lunghi,Mirko Pinotti,Giovanna Marchetti,Giovanni Malerba,Pier Franco Pignatti,Roberto Corrocher,Oliviero Olivieri,Francesco Bernardi
View Articletitled, Polymorphisms at <em>LDLR</em> locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
Supplemental data
Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
Chunlei Zheng,Hui-hui Liu,Shuguang Yuan,Jiahai Zhou,Bin Zhang
View Articletitled, Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
Supplemental data
Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D
Kenneth M. Wannemacher,Li Zhu,Hong Jiang,Karen P. Fong,Timothy J. Stalker,Dooyoung Lee,Anh N. Tran,Keith B. Neeves,Sean Maloney,Atsushi Kumanogoh,Hitoshi Kikutani,Daniel A. Hammer,Scott L. Diamond,Lawrence F. Brass
View Articletitled, Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D
Supplemental data
Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model
Petr Klement,Leslie R. Berry,Peng Liao,Henry Wood,Paul Tressel,Lesley J. Smith,Nihal Haque,Jeffery I. Weitz,Jack Hirsh,Nethnapha Paredes,Anthony K.C. Chan
View Articletitled, Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model
Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice
Sarah M. Nordstrom,Brian A. Holliday,Brandon C. Sos,James W. Smyth,Robert E. Levy,Jonathan W. Dukes,Susan T. Lord,Ethan J. Weiss
View Articletitled, Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice
Supplemental data
Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery
Brief Report
Yesim Dargaud,Anne Lienhart,Claude Negrier
View Articletitled, Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery

Transplantation

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13
Steven L. Highfill,Paulo C. Rodriguez,Qing Zhou,Christine A. Goetz,Brent H. Koehn,Rachelle Veenstra,Patricia A. Taylor,Angela Panoskaltsis-Mortari,Jonathan S. Serody,David H. Munn,Jakub Tolar,Augusto C. Ochoa,Bruce R. Blazar
View Articletitled, Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13
Supplemental data
Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells
Brief Report
Raewyn Broady,Jie Yu,Vickie Chow,Adisak Tantiworawit,Christine Kang,Kyra Berg,Magdalena Martinka,Mehran Ghoreishi,Jan Dutz,Megan K. Levings
View Articletitled, Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells
Supplemental data

Vascular Biology

Membrane-type MMPs are indispensable for placental labyrinth formation and development
Ludmila Szabova,Mee-Young Son,Joanne Shi,Marek Sramko,Susan S. Yamada,William D. Swaim,Patricia Zerfas,Stacie Kahan,Kenn Holmbeck
View Articletitled, Membrane-type MMPs are indispensable for placental labyrinth formation and development
Supplemental data
Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways
Sang-Wook Park,Young Jun Koh,Jongwook Jeon,Yun-Hee Cho,Mi-Jin Jang,Yujung Kang,Min-Jeong Kim,Chulhee Choi,Yee Sook Cho,Hyung-Min Chung,Gou Young Koh,Yong-Mahn Han
View Articletitled, Efficient differentiation of human pluripotent stem cells into functional CD34<sup>+</sup> progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways
Supplemental data
A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting
Hui Jin,Barbara Garmy-Susini,Christie J. Avraamides,Konstantin Stoletov,Richard L. Klemke,Judith A. Varner
View Articletitled, A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    The cover image shows hESC-derived cells expressing endothelial specific markers. When hESC-derived CD34+ cells were cultured in endothelial growth medium, endothelial specific markers such as VE-cadherin (red) and von Willebrand factor (vWF, green) were shown to be expressed at cell-cell junctions or around the nuclei (blue), respectively. These cells could recapitulate functional vasculogenesis in vitro and in vivo. See the article by Park et al on page 5762.

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