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Issue Archive

Volume 116, Issue 24
December 9 2010
Blood Cover Image for Volume 116, Issue 24

Table of Contents

Inside blood

CLINICAL TRIALS
Hepatitis C in the rituximab era
James M. Foran
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HEMATOPOIESIS & STEM CELLS
ABC of D's in the folate transporter
Ralph Green
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IMMUNOBIOLOGY
A gut feeling about plasmablasts
David Tarlinton
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THROMBOSIS & HEMOSTASIS
En route to personalized prophylaxis
Agnes Y. Y. Lee
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TRANSPLANTATION
CCR7 alters hematopoietic potential
Edward F. Srour
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Review Article

FLT3 as a therapeutic target in AML: still challenging after all these years
Thomas Kindler,Daniel B. Lipka,Thomas Fischer
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How I treat

How I treat elderly patients with diffuse large B-cell lymphoma
Michael Pfreundschuh
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Clinical Trials and Observations

Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
John R. Wingard,Shelly L. Carter,Thomas J. Walsh,Joanne Kurtzberg,Trudy N. Small,Lindsey R. Baden,Iris D. Gersten,Adam M. Mendizabal,Helen L. Leather,Dennis L. Confer,Richard T. Maziarz,Edward A. Stadtmauer,Javier Bolaños-Meade,Janice Brown,John F. DiPersio,Michael Boeckh,Kieren A. Marr,for The Blood and Marrow Transplant Clinical Trials Network
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Supplemental data
Hepatic toxicity and prognosis in hepatitis C virus–infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis
Clinical Trials & Observations
Daisuke Ennishi,Yoshinobu Maeda,Nozomi Niitsu,Minoru Kojima,Koji Izutsu,Jun Takizawa,Shigeru Kusumoto,Masataka Okamoto,Masahiro Yokoyama,Yasushi Takamatsu,Kazutaka Sunami,Akira Miyata,Kayoko Murayama,Akira Sakai,Morio Matsumoto,Katsuji Shinagawa,Akinobu Takaki,Keitaro Matsuo,Tomohiro Kinoshita,Mitsune Tanimoto
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Supplemental data
Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features
Clinical Trials & Observations
Shaji Kumar,Angela Dispenzieri,Jerry A. Katzmann,Dirk R. Larson,Colin L. Colby,Martha Q. Lacy,Suzanne R. Hayman,Francis K. Buadi,Nelson Leung,Steve R. Zeldenrust,Marina Ramirez-Alvarado,Raynell J. Clark,Robert A. Kyle,S. Vincent Rajkumar,Morie A. Gertz
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Adaptation to anemia in hemoglobin E-β thalassemia
Brief Report
Angela Allen,Christopher Fisher,Anuja Premawardhena,Timothy Peto,Stephen Allen,Mahinda Arambepola,Vivekanandan Thayalsutha,Nancy Olivieri,David Weatherall
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Gene therapy

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model
Ilaria Visigalli,Stefania Delai,Letterio S. Politi,Carmela Di Domenico,Federica Cerri,Emanuela Mrak,Raffaele D'Isa,Daniela Ungaro,Merel Stok,Francesca Sanvito,Elisabetta Mariani,Lidia Staszewsky,Claudia Godi,Ilaria Russo,Francesca Cecere,Ubaldo del Carro,Alessandro Rubinacci,Riccardo Brambilla,Angelo Quattrini,Paola Di Natale,Katherine Ponder,Luigi Naldini,Alessandra Biffi
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Supplemental data

Hematopoiesis and Stem Cells

Fancd2−/− mice have hematopoietic defects that can be partially corrected by resveratrol
Qing-Shuo Zhang,Laura Marquez-Loza,Laura Eaton,Andrew W. Duncan,Devorah C. Goldman,Praveen Anur,Kevin Watanabe-Smith,R. Keaney Rathbun,William H. Fleming,Grover C. Bagby,Markus Grompe
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Supplemental data
Evidence that Growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells
Cyrus Khandanpour,Ehssan Sharif-Askari,Lothar Vassen,Marie-Claude Gaudreau,Jinfang Zhu,William E. Paul,Taro Okayama,Christian Kosan,Tarik Möröy
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Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice
Brief Report
Xingkui Xue,Nancy K. Pech,W. Christopher Shelley,Edward F. Srour,Mervin C. Yoder,Mary C. Dinauer
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Supplemental data

Immunobiology

Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus
Federica Moalli,Andrea Doni,Livija Deban,Teresa Zelante,Silvia Zagarella,Barbara Bottazzi,Luigina Romani,Alberto Mantovani,Cecilia Garlanda
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Supplemental data
Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab
Henrik E. Mei,Daniela Frölich,Claudia Giesecke,Christoph Loddenkemper,Karin Reiter,Stefanie Schmidt,Eugen Feist,Capucine Daridon,Hans-Peter Tony,Andreas Radbruch,Thomas Dörner
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Supplemental data
IL-21 induces death of marginal zone B cells during chronic inflammation
Luigi Tortola,Koshika Yadava,Martin F. Bachmann,Christoph Müller,Jan Kisielow,Manfred Kopf
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Lymphoid Neoplasia

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway
Xiaoyu Jiang,Xiaoqing Lu,George McNamara,Xiaofei Liu,Elena Cubedo,Kristopher A. Sarosiek,Isidro Sánchez-García,David M. Helfman,Izidore S. Lossos
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Supplemental data
Follicular dendritic cell–dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion–mediated Bim down-regulation through induction of microRNA-181a
Tint Lwin,Jianhong Lin,Yong Sung Choi,Xinwei Zhang,Lynn C. Moscinski,Kenneth L. Wright,Eduardo M. Sotomayor,William S. Dalton,Jianguo Tao
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Supplemental data
A role for proapoptotic Bax and Bak in T-cell differentiation and transformation
Subhrajit Biswas,Qiong Shi,Lauren Matise,Susan Cleveland,Utpal Dave,Sandra Zinkel
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Supplemental data
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
Irina Velichutina,Rita Shaknovich,Huimin Geng,Nathalie A. Johnson,Randy D. Gascoyne,Ari M. Melnick,Olivier Elemento
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Supplemental data
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Lina Happo,Mark S. Cragg,Belinda Phipson,Jon M. Haga,Elisa S. Jansen,Marco J. Herold,Grant Dewson,Ewa M. Michalak,Cassandra J. Vandenberg,Gordon K. Smyth,Andreas Strasser,Suzanne Cory,Clare L. Scott
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Supplemental data
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance
Priscilla P. L. Chiu,Hong Jiang,John E. Dick
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Supplemental data
Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells
Brief Report
N. Deepa Pantulu,Christian P. Pallasch,Anna Kordelia Kurz,Ahmad Kassem,Lukas Frenzel,Sebastian Sodenkamp,Hans Michael Kvasnicka,Clemens M. Wendtner,Axel zur Hausen
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Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes
Brief Report
Ebenezer David,Jonathan L. Kaufman,Christopher R. Flowers,Katherine Schafer-Hales,Claire Torre,Jing Chen,Adam I. Marcus,Shi-Yong Sun,Lawrence H. Boise,Sagar Lonial
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Supplemental data

Myeloid Neoplasia

Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells
Zhi-Min Gu,Ying-Li Wu,Mei-Yi Zhou,Chuan-Xu Liu,Han-Zhang Xu,Hua Yan,Yong Zhao,Ying Huang,Han-Dong Sun,Guo-Qiang Chen
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Supplemental data
Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy
Jinshui Fan,Li Li,Donald Small,Feyruz Rassool
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Supplemental data
Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists
Aditya Mandawat,Warren Fiskus,Kathleen M. Buckley,Kelly Robbins,Rekha Rao,Ramesh Balusu,Jean-Marc Navenot,Zi-Xuan Wang,Celalettin Ustun,Daniel G. Chong,Peter Atadja,Nobutaka Fujii,Stephen C. Peiper,Kapil Bhalla
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Complete characterization of the microRNAome in a patient with acute myeloid leukemia
Giridharan Ramsingh,Daniel C. Koboldt,Maria Trissal,Katherine B. Chiappinelli,Todd Wylie,Sunita Koul,Li-Wei Chang,Rakesh Nagarajan,Todd A. Fehniger,Paul Goodfellow,Vincent Magrini,Richard K. Wilson,Li Ding,Timothy J. Ley,Elaine R. Mardis,Daniel C. Link
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Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG
Cees E. van der Poel,Roos A. Karssemeijer,Peter Boross,Joke A. van der Linden,Miranda Blokland,Jan G. J. van de Winkel,Jeanette H. W. Leusen
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Supplemental data
Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity
Florence Vallelian,Christian A. Schaer,Theresa Kaempfer,Peter Gehrig,Elena Duerst,Gabriele Schoedon,Dominik J. Schaer
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Supplemental data
CCR7 impairs hematopoiesis after hematopoietic stem cell transplantation increasing susceptibility to invasive aspergillosis
Adam J. Hartigan,Lara E. Kallal,Cory M. Hogaboam
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Supplemental data

Red Cells, Iron, and Erythropoiesis

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption
Daniel Sanghoon Shin,Sang Hee Min,Laura Russell,Rongbao Zhao,Andras Fiser,I. David Goldman
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During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool
Arvind Dev,Jing Fang,Pradeep Sathyanarayana,Anamika Pradeep,Christine Emerson,Don M. Wojchowski
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Supplemental data
Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis
Hana Forejtnikovà,Maud Vieillevoye,Yael Zermati,Mireille Lambert,Rosa Maria Pellegrino,Soizic Guihard,Muriel Gaudry,Clara Camaschella,Catherine Lacombe,Antonella Roetto,Patrick Mayeux,Frédérique Verdier
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Supplemental data

Thrombosis and Hemostasis

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo
Michael W. Munks,Amy S. McKee,Megan K. MacLeod,Roger L. Powell,Jay L. Degen,Nichole A. Reisdorph,John W. Kappler,Philippa Marrack
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Supplemental data
The dominant-negative von Willebrand factor gene deletion p.P1127_C1948delinsR: molecular mechanism and modulation
Caterina Casari,Mirko Pinotti,Stefano Lancellotti,Elena Adinolfi,Alessandra Casonato,Raimondo De Cristofaro,Francesco Bernardi
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Supplemental data
Prediction of venous thromboembolism in cancer patients
Clinical Trials & Observations
Cihan Ay,Daniela Dunkler,Christine Marosi,Alexandru-Laurentiu Chiriac,Rainer Vormittag,Ralph Simanek,Peter Quehenberger,Christoph Zielinski,Ingrid Pabinger
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Transplantation

The requirement for NKG2D in NK cell–mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient
Joshua N. Beilke,Jonathan Benjamin,Lewis L. Lanier
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Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
Clinical Trials & Observations
Cristina Cunha,Mauro Di Ianni,Silvia Bozza,Gloria Giovannini,Silvia Zagarella,Teresa Zelante,Carmen D'Angelo,Antonio Pierini,Lucia Pitzurra,Franca Falzetti,Alessandra Carotti,Katia Perruccio,Jean-Paul Latgé,Fernando Rodrigues,Andrea Velardi,Franco Aversa,Luigina Romani,Agostinho Carvalho
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GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28− CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression
Weston P. Miller,Swetha Srinivasan,Angela Panoskaltsis-Mortari,Karnail Singh,Sharon Sen,Kelly Hamby,Taylor Deane,Linda Stempora,Jonathan Beus,Alexa Turner,Caleb Wheeler,Daniel C. Anderson,Prachi Sharma,Anapatricia Garcia,Elizabeth Strobert,Eric Elder,Ian Crocker,Timothy Crenshaw,M. Cecilia T. Penedo,Thea Ward,Mingqing Song,John Horan,Christian P. Larsen,Bruce R. Blazar,Leslie S. Kean
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Supplemental data

Vascular Biology

Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway
Baofeng Zhao,Changzoon Chun,Zhong Liu,Mark A. Horswill,Kallal Pramanik,George A. Wilkinson,Ramani Ramchandran,Robert Q. Miao
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Supplemental data
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