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Issue Archive

Volume 116, Issue 18
November 4 2010
Issue Cover

Table of Contents

Inside blood

IMMUNOBIOLOGY
The multifaceted granulysin
Laurence Zitvogel,Guido Kroemer
View Articletitled, The multifaceted granulysin
INSIDE BLOOD
“Skulls and bones” new member: Th17
Eduardo M. Sotomayor
View Articletitled, “Skulls and bones” new member: Th17
MYELOID NEOPLASIA
Wrapping BCR-ABL: it's in the bag
Junia V. Melo,Duncan R. Hewett
View Articletitled, Wrapping BCR-ABL: it's in the bag
RED CELLS & IRON
BMP-2: a culprit for anemia in myeloma
Heinz Ludwig
View Articletitled, BMP-2: a culprit for anemia in myeloma
TRANSFUSION MEDICINE
FNAIT: the fetus pleads guilty!
Cécile Kaplan
View Articletitled, FNAIT: the fetus pleads guilty!
VASCULAR BIOLOGY
Gremlin: vexing VEGF receptor agonist
Lena Claesson-Welsh
View Articletitled, Gremlin: vexing VEGF receptor agonist

Blood Work

Waldenström macroglobulinemia with pseudo-Gaucher cells
View Articletitled, Waldenström macroglobulinemia with pseudo-Gaucher cells

Plenary paper

IMMUNOBIOLOGY
Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)
Yves Lepelletier,Raphaël Zollinger,Cristina Ghirelli,Françoise Raynaud,Réda Hadj-Slimane,Antonio Cappuccio,Olivier Hermine,Yong-Jun Liu,Vassili Soumelis
View Articletitled, Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)
Supplemental data

Review Article

X-linked lymphoproliferative syndromes: brothers or distant cousins?
Alexandra H. Filipovich,Kejian Zhang,Andrew L. Snow,Rebecca A. Marsh
View Articletitled, X-linked lymphoproliferative syndromes: brothers or distant cousins?

How I treat

How I treat Philadelphia chromosome–positive acute lymphoblastic leukemia
Adele K. Fielding
View Articletitled, How I treat Philadelphia chromosome–positive acute lymphoblastic leukemia

Clinical Trials and Observations

Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group
Clinical Trials & Observations
Norbert Schmitz,Lorenz Trümper,Marita Ziepert,Maike Nickelsen,Anthony D. Ho,Bernd Metzner,Norma Peter,Markus Loeffler,Andreas Rosenwald,Michael Pfreundschuh
View Articletitled, Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group
Supplemental data
The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis
Clinical Trials & Observations
Giovanni Palladini,Alessandra Barassi,Catherine Klersy,Rosana Pacciolla,Paolo Milani,Gabriele Sarais,Stefano Perlini,Riccardo Albertini,Paola Russo,Andrea Foli,Letizia Zenone Bragotti,Laura Obici,Remigio Moratti,Gian Vico Melzi d'Eril,Giampaolo Merlini
View Articletitled, The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis
Supplemental data
A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma
Clinical Trials & Observations
Kimberly A. Bertrand,Brenda M. Birmann,Ellen T. Chang,Donna Spiegelman,Jon C. Aster,Shumin M. Zhang,Francine Laden
View Articletitled, A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma
FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Brief Report
Susan P. Whitman,Kati Maharry,Michael D. Radmacher,Heiko Becker,Krzysztof Mrózek,Dean Margeson,Kelsi B. Holland,Yue-Zhong Wu,Sebastian Schwind,Klaus H. Metzeler,Jing Wen,Maria R. Baer,Bayard L. Powell,Thomas H. Carter,Jonathan E. Kolitz,Meir Wetzler,Joseph O. Moore,Richard M. Stone,Andrew J. Carroll,Richard A. Larson,Michael A. Caligiuri,Guido Marcucci,Clara D. Bloomfield
View Articletitled, <em>FLT3</em> internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Supplemental data

Hematopoiesis and Stem Cells

Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters
Ann C. Zovein,Kirsten A. Turlo,Ryan M. Ponec,Maureen R. Lynch,Kevin C. Chen,Jennifer J. Hofmann,Timothy C. Cox,Judith C. Gasson,M. Luisa Iruela-Arispe
View Articletitled, Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters
Supplemental data
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells
Dan Xu,Siying Wang,Wen-Mei Yu,Gordon Chan,Toshiyuki Araki,Kevin D. Bunting,Benjamin G. Neel,Cheng-Kui Qu
View Articletitled, A germline gain-of-function mutation in <em>Ptpn11</em> (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells
Supplemental data

Immunobiology

The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress
Holger W. Auner,Christine Beham-Schmid,Niall Dillon,Pierangela Sabbattini
View Articletitled, The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress
Supplemental data
Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs
Alexei V. Tumanov,Sergei I. Grivennikov,Andrei A. Kruglov,Yuriy V. Shebzukhov,Ekaterina P. Koroleva,Yulan Piao,Chang-Yi Cui,Dmitry V. Kuprash,Sergei A. Nedospasov
View Articletitled, Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs
Supplemental data
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin
Poonam Tewary,De Yang,Gonzalo de la Rosa,Yana Li,Michael W. Finn,Alan M. Krensky,Carol Clayberger,Joost J. Oppenheim
View Articletitled, Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin
Supplemental data
Pannexin-1 hemichannel–mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
Tobias Woehrle,Linda Yip,Abdallah Elkhal,Yuka Sumi,Yu Chen,Yongli Yao,Paul A. Insel,Wolfgang G. Junger
View Articletitled, Pannexin-1 hemichannel–mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
Supplemental data
Th1-driven immune reconstitution disease in Mycobacterium avium–infected mice
Daniel L. Barber,Katrin D. Mayer-Barber,Lis R. V. Antonelli,Mark S. Wilson,Sandra White,Patricia Caspar,Sara Hieny,Irini Sereti,Alan Sher
View Articletitled, Th1-driven immune reconstitution disease in <em>Mycobacterium avium</em>–infected mice
Supplemental data
When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function
Degui Geng,Liqin Zheng,Ratika Srivastava,Nicole Asprodites,Cruz Velasco-Gonzalez,Eduardo Davila
View Articletitled, When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function
In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
Gabriel Courties,Virginia Seiffart,Jessy Presumey,Virginie Escriou,Daniel Scherman,Jochen Zwerina,Gisela Ruiz,Natalia Zietara,Jadwiga Jablonska,Siegfried Weiss,Andrea Hoffmann,Christian Jorgensen,Florence Apparailly,Gerhard Gross
View Articletitled, In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
Supplemental data
Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues
Yasuyuki Saito,Hiroko Iwamura,Tetsuya Kaneko,Hiroshi Ohnishi,Yoji Murata,Hideki Okazawa,Yoshitake Kanazawa,Miho Sato-Hashimoto,Hisae Kobayashi,Per-Arne Oldenborg,Makoto Naito,Yoriaki Kaneko,Yoshihisa Nojima,Takashi Matozaki
View Articletitled, Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues
Supplemental data
Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant
Teresa Freire,Xiaoming Zhang,Edith Dériaud,Christelle Ganneau,Sophie Vichier-Guerre,Elie Azria,Odile Launay,Richard Lo-Man,Sylvie Bay,Claude Leclerc
View Articletitled, Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant
Supplemental data

Lymphoid Neoplasia

HS1 has a central role in the trafficking and homing of leukemic B cells
Cristina Scielzo,Maria T. S. Bertilaccio,Giorgia Simonetti,Antonis Dagklis,Elisa ten Hacken,Claudia Fazi,Marta Muzio,Valeria Caiolfa,Daisuke Kitamura,Umberto Restuccia,Angela Bachi,Martina Rocchi,Maurilio Ponzoni,Paolo Ghia,Federico Caligaris-Cappio
View Articletitled, HS1 has a central role in the trafficking and homing of leukemic B cells
Supplemental data
A novel role of IL-17–producing lymphocytes in mediating lytic bone disease in multiple myeloma
Kimberly Noonan,Luigi Marchionni,Judy Anderson,Drew Pardoll,G. David Roodman,Ivan Borrello
View Articletitled, A novel role of IL-17–producing lymphocytes in mediating lytic bone disease in multiple myeloma

Myeloid Neoplasia

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
Carsten Müller-Tidow,Hans-Ulrich Klein,Antje Hascher,Fabienne Isken,Lara Tickenbrock,Nils Thoennissen,Shuchi Agrawal-Singh,Petra Tschanter,Christine Disselhoff,Yipeng Wang,Anke Becker,Christian Thiede,Gerhard Ehninger,Udo zur Stadt,Steffen Koschmieder,Matthias Seidl,Frank U. Müller,Wilhelm Schmitz,Peter Schlenke,Michael McClelland,Wolfgang E. Berdel,Martin Dugas,Hubert Serve,on behalf of the Study Alliance Leukemia
View Articletitled, Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
Supplemental data
Bag1 directly routes immature BCR-ABL for proteasomal degradation
Fujiko Tsukahara,Yoshiro Maru
View Articletitled, Bag1 directly routes immature BCR-ABL for proteasomal degradation
Supplemental data
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
Sumaiya Sharmeen,Marko Skrtic,Mahadeo A. Sukhai,Rose Hurren,Marcela Gronda,Xiaoming Wang,Sonali B. Fonseca,Hong Sun,Tabitha E. Wood,Richard Ward,Mark D. Minden,Robert A. Batey,Alessandro Datti,Jeff Wrana,Shana O. Kelley,Aaron D. Schimmer
View Articletitled, The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
Supplemental data
A protease-resistant PML-RARα has increased leukemogenic potential in a murine model of acute promyelocytic leukemia
Geoffrey L. Uy,Andrew A. Lane,John S. Welch,Nicole R. Grieselhuber,Jacqueline E. Payton,Timothy J. Ley
View Articletitled, A protease-resistant PML-RARα has increased leukemogenic potential in a murine model of acute promyelocytic leukemia
Supplemental data

Platelets and Thrombopoiesis

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy
Pingguo Chen,Conglei Li,Sean Lang,Guangheng Zhu,Adili Reheman,Christopher M. Spring,John Freedman,Heyu Ni
View Articletitled, Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

Red Cells, Iron, and Erythropoiesis

Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease
Brief Report
John J. Strouse,Megan E. Reller,David G. Bundy,Martha Amoako,Maria Cancio,Rachel N. Han,Alexandra Valsamakis,James F. Casella
View Articletitled, Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease
Supplemental data
Down-regulation of hepcidin resulting from long-term treatment with an anti–IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
Clinical Trials & Observations
Soken-Nakazawa J. Song,Naohisa Tomosugi,Hiroshi Kawabata,Takayuki Ishikawa,Teppei Nishikawa,Kazuyuki Yoshizaki
View Articletitled, Down-regulation of hepcidin resulting from long-term treatment with an anti–IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
Supplemental data
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
Ken Maes,Elizabeta Nemeth,G. David Roodman,Alissa Huston,Flavia Esteve,Cesar Freytes,Natalie Callander,Eirini Katodritou,Lisa Tussing-Humphreys,Seth Rivera,Karin Vanderkerken,Alan Lichtenstein,Tomas Ganz
View Articletitled, In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
Supplemental data

Thrombosis and Hemostasis

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease
Maha Othman,Yvette Chirinian,Christine Brown,Colleen Notley,Nicholas Hickson,Daniel Hampshire,Suzanne Buckley,Simon Waddington,Alan L. Parker,Andrew Baker,Paula James,David Lillicrap
View Articletitled, Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease
Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice
Jing Huang,David G. Motto,David R. Bundle,J. Evan Sadler
View Articletitled, Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice
Supplemental data

Transplantation

Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis
Clinical Trials & Observations
Haefaa Alchalby,Anita Badbaran,Tatjana Zabelina,Guido Kobbe,Joachim Hahn,Daniel Wolff,Martin Bornhäuser,Christian Thiede,Herrad Baurmann,Wolfgang Bethge,York Hildebrandt,Ulrike Bacher,Boris Fehse,Axel R. Zander,Nicolaus Kröger
View Articletitled, Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis

Vascular Biology

Low-dose radiation augments vasculogenesis signaling through HIF-1–dependent and –independent SDF-1 induction
Oren Z. Lerman,Matthew R. Greives,Sunil P. Singh,Vishal D. Thanik,Christopher C. Chang,Natalie Seiser,Daniel J. Brown,Denis Knobel,Robert J. Schneider,Silvia C. Formenti,Pierre B. Saadeh,Jamie P. Levine
View Articletitled, Low-dose radiation augments vasculogenesis signaling through HIF-1–dependent and –independent SDF-1 induction
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
Brief Report
Stefania Mitola,Cosetta Ravelli,Emanuela Moroni,Valentina Salvi,Daria Leali,Kurt Ballmer-Hofer,Luca Zammataro,Marco Presta
View Articletitled, Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
Supplemental data

Correspondence

Coenzyme Q is effective on anemia in a patient with sideroblastic anemia and mitochondrial myopathy
Claude Bachmeyer,Jean-Pierre Ferroir,Bruno Eymard,Micheline Maïer-Redelsperger,Anne-Sophie Lebre,Robert Girot
View Articletitled, Coenzyme Q is effective on anemia in a patient with sideroblastic anemia and mitochondrial myopathy
CD21low B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells
Mirzokhid Rakhmanov,Sylvia Gutenberger,Baerbel Keller,Michael Schlesier,Hans-Hartmut Peter,Klaus Warnatz
View Articletitled, CD21<sup>low</sup> B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells
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