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Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value
Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study
Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as “AML not otherwise specified” (AML-NOS) or “AML with myelodysplasia-related changes” (AML-MRC)
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine
Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-β–deficient neutrophils in a congenital neutropenia syndrome
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait
RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management
Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
Issue Archive
October 14 2010
In this Issue
Table of Contents
Inside blood
Review Article
Clinical Trials and Observations
Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2
Clinical Trials & Observations
Marie Meeths,Miriam Entesarian,Waleed Al-Herz,Samuel C. C. Chiang,Stephanie M. Wood,Wafa Al-Ateeqi,Francisco Almazan,Jaap J. Boelens,Henrik Hasle,Marianne Ifversen,Bendik Lund,J. Merlijn van den Berg,Britt Gustafsson,Hans Hjelmqvist,Magnus Nordenskjöld,Yenan T. Bryceson,Jan-Inge Henter
Gene therapy
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors
Raul Alba,Angela C. Bradshaw,Lynda Coughlan,Laura Denby,Robert A. McDonald,Simon N. Waddington,Suzanne M. K. Buckley,Jenny A. Greig,Alan L. Parker,Ashley M. Miller,Hongjie Wang,Andre Lieber,Nico van Rooijen,John H. McVey,Stuart A. Nicklin,Andrew H. Baker
Hematopoiesis and Stem Cells
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
Zane Orinska,Niko Föger,Michael Huber,Julia Marschall,Farhad Mirghomizadeh,Xin Du,Marina Scheller,Philip Rosenstiel,Torsten Goldmann,Annalena Bollinger,Bruce A. Beutler,Silvia Bulfone-Paus
Lymphoid Neoplasia
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value
e-blood
Brian A. Walker,Paola E. Leone,Laura Chiecchio,Nicholas J. Dickens,Matthew W. Jenner,Kevin D. Boyd,David C. Johnson,David Gonzalez,Gian Paolo Dagrada,Rebecca K. M. Protheroe,Zoe J. Konn,David M. Stockley,Walter M. Gregory,Faith E. Davies,Fiona M. Ross,Gareth J. Morgan
Myeloid Neoplasia
Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study
Clinical Trials & Observations
Georg Mann,Andishe Attarbaschi,Martin Schrappe,Paola De Lorenzo,Christina Peters,Ian Hann,Giulio De Rossi,Maria Felice,Birgitte Lausen,Thierry LeBlanc,Tomasz Szczepanski,Alina Ferster,Gritta Janka-Schaub,Jeffrey Rubnitz,Lewis B. Silverman,Jan Stary,Myriam Campbell,Chi Kong Li,Ram Suppiah,Andrea Biondi,Ajay Vora,Maria Grazia Valsecchi,Rob Pieters,on behalf of the Interfant-99 Study Group
Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as “AML not otherwise specified” (AML-NOS) or “AML with myelodysplasia-related changes” (AML-MRC)
Clinical Trials & Observations
Miriam Miesner,Claudia Haferlach,Ulrike Bacher,Tamara Weiss,Katja Macijewski,Alexander Kohlmann,Hans-Ulrich Klein,Martin Dugas,Wolfgang Kern,Susanne Schnittger,Torsten Haferlach
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine
Clinical Trials & Observations
Costa Bachas,Gerrit Jan Schuurhuis,Iris H. I. M. Hollink,Zinia J. Kwidama,Bianca F. Goemans,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink,Eveline S. J. M. de Bont,Dirk Reinhardt,Ursula Creutzig,Valerie de Haas,Yehuda G. Assaraf,Gertjan J. L. Kaspers,Jacqueline Cloos
Phagocytes, Granulocytes, and Myelopoiesis
Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-β–deficient neutrophils in a congenital neutropenia syndrome
Clinical Trials & Observations
Hyun Sik Jun,Young Mok Lee,Yuk Yin Cheung,David H. McDermott,Philip M. Murphy,Suk See De Ravin,Brian C. Mansfield,Janice Y. Chou
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
Clinical Trials & Observations
David H. McDermott,Suk See De Ravin,Hyun Sik Jun,Qian Liu,Debra A. Long Priel,Pierre Noel,Clifford M. Takemoto,Teresa Ojode,Scott M. Paul,Kimberly P. Dunsmore,Dianne Hilligoss,Martha Marquesen,Jean Ulrick,Douglas B. Kuhns,Janice Y. Chou,Harry L. Malech,Philip M. Murphy
Red Cells, Iron, and Erythropoiesis
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q− polycythemia vera
Fabiana Perna,Nadia Gurvich,Ruben Hoya-Arias,Omar Abdel-Wahab,Ross L. Levine,Takashi Asai,Francesca Voza,Silvia Menendez,Lan Wang,Fan Liu,Xinyang Zhao,Stephen D. Nimer
Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait
Clinical Trials & Observations
Jeffrey J. Swensen,Archana M. Agarwal,Jose M. Esquilin,Sabina Swierczek,Ajay Perumbeti,Dottie Hussey,Margaret Lee,Clinton H. Joiner,Genevieve Pont-Kingdon,Elaine Lyon,Josef T. Prchal
Transfusion Medicine
RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management
Brief Report
Ross M. Fasano,Alessandro Monaco,Emily Riehm Meier,Philippe Pary,A. Hallie Lee-Stroka,John Otridge,Harvey G. Klein,Francesco M. Marincola,Naynesh R. Kamani,Naomi L. C. Luban,David Stroncek,Willy A. Flegel
Transplantation
Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
Clinical Trials & Observations
Vascular Biology
Nanoparticle-induced vascular blockade in human prostate cancer
Lilach Agemy,Kazuki N. Sugahara,Venkata Ramana Kotamraju,Kunal Gujraty,Olivier M. Girard,Yuko Kono,Robert F. Mattrey,Ji-Ho Park,Michael J. Sailor,Ana I. Jimenez,Carlos Cativiela,David Zanuy,Francisco J. Sayago,Carlos Aleman,Ruth Nussinov,Erkki Ruoslahti
Correspondence
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Cover Image
Cover Image
![issue cover]()
Three-dimensional reconstruction of bone marrow whole-mount tissue (1.2 mm × 1.2 mm × 100 μm) from a patient with severe aplastic anemia, showing most of the hematopoietic space occupied by adipocytes (green), with visualization also of the vascular network (CD34, red) and residual hematopoietic cell nuclei (DAPI, blue). See the article by Takaku et al on page e41.
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