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Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications
Phase 2 study of BACOPP (bleomycin, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) in older patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)
Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte
First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma
Issue Archive
September 23 2010
In this Issue
Table of Contents
Inside blood
Plenary Paper
THROMBOSIS AND HEMOSTASIS
Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)
Hendrik B. Feys,Jan Roodt,Nele Vandeputte,Inge Pareyn,Seb Lamprecht,Walter J. van Rensburg,Patricia J. Anderson,Ulrich Budde,Vernon J. Louw,Philip N. Badenhorst,Hans Deckmyn,Karen Vanhoorelbeke
Perspectives
Clinical Trials and Observations
Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications
CME
Giada Bianchi,Robert A. Kyle,Colin L. Colby,Dirk R. Larson,Shaji Kumar,Jerry A. Katzmann,Angela Dispenzieri,Terry M. Therneau,James R. Cerhan,L. Joseph Melton, III,S. Vincent Rajkumar
Phase 2 study of BACOPP (bleomycin, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) in older patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)
Clinical Trials & Observations
Teresa V. Halbsguth,Lucia Nogová,Horst Mueller,Michal Sieniawski,Dennis A. Eichenauer,Thomas Schober,Hiltrud Nisters-Backes,Peter Borchmann,Volker Diehl,Andreas Engert,Andreas Josting
Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte
Clinical Trials & Observations
Bertrand Coiffier,Catherine Thieblemont,Eric Van Den Neste,Gérard Lepeu,Isabelle Plantier,Sylvie Castaigne,Sophie Lefort,Gérald Marit,Margaret Macro,Catherine Sebban,Karim Belhadj,Dominique Bordessoule,Christophe Fermé,Hervé Tilly
First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia
Clinical Trials & Observations
Farhad Ravandi,Susan O'Brien,Deborah Thomas,Stefan Faderl,Dan Jones,Rebecca Garris,Samuel Dara,Jeffrey Jorgensen,Partow Kebriaei,Richard Champlin,Gautam Borthakur,Jan Burger,Alessandra Ferrajoli,Guillermo Garcia-Manero,William Wierda,Jorge Cortes,Hagop Kantarjian
Hematopoiesis and Stem Cells
Immunobiology
Lymphoid Neoplasia
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
Sarah E. M. Herman,Amber L. Gordon,Amy J. Wagner,Nyla A. Heerema,Weiqiang Zhao,Joseph M. Flynn,Jeffrey Jones,Leslie Andritsos,Kamal D. Puri,Brian J. Lannutti,Neill A. Giese,Xiaoli Zhang,Lai Wei,John C. Byrd,Amy J. Johnson
Myeloid Neoplasia
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL–positive leukemic cells
Ruriko Tanaka,Matthew S. Squires,Shinya Kimura,Asumi Yokota,Rina Nagao,Takahiro Yamauchi,Miki Takeuchi,Hisayuki Yao,Matthias Reule,Tomoko Smyth,John F. Lyons,Neil T. Thompson,Eishi Ashihara,Oliver G. Ottmann,Taira Maekawa
A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias
Alicja M. Gruszka,Serena Lavorgna,Maria Irno Consalvo,Tiziana Ottone,Chiara Martinelli,Mario Cinquanta,Giuseppe Ossolengo,Giancarlo Pruneri,Francesco Buccisano,Mariadomenica Divona,Michele Cedrone,Emanuele Ammatuna,Adriano Venditti,Ario de Marco,Francesco Lo-Coco,Pier Giuseppe Pelicci
Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate
Xiaoyan Jiang,Donna Forrest,Franck Nicolini,Ali Turhan,Joelle Guilhot,Calvin Yip,Tessa Holyoake,Heather Jorgensen,Karen Lambie,Kyi Min Saw,Emily Pang,Ranko Vukovic,Paeta Lehn,Ashley Ringrose,Miao Yu,Ryan R. Brinkman,Clay Smith,Allen Eaves,Connie Eaves
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
Brief Report
Saman Abbas,Sanne Lugthart,François G. Kavelaars,Anita Schelen,Jasper E. Koenders,Annelieke Zeilemaker,Wim J. L. van Putten,Anita W. Rijneveld,Bob Löwenberg,Peter J. M. Valk
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Vegf regulates embryonic erythroid development through Gata1 modulation
Benjamin Drogat,Joanna Kalucka,Laura Gutiérrez,Hamida Hammad,Steven Goossens,Morvarid Farhang Ghahremani,Sonia Bartunkova,Katharina Haigh,Kim Deswarte,Omar Nyabi,Michael Naessens,Napoleone Ferrara,Ursula Klingmüller,Bart N. Lambrecht,Andras Nagy,Sjaak Philipsen,Jody J. Haigh
Thrombosis and Hemostasis
Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
Brief Report
Matthew B. Lanktree,Christopher T. Johansen,Sonia S. Anand,A. Darlene Davis,Ruby Miller,Salim Yusuf,Robert A. Hegele,on behalf of the SHARE, and SHARE-AP Investigators
Transplantation
Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma
Clinical Trials & Observations
Ian H. Gabriel,Ruhena Sergeant,Richard Szydlo,Jane F. Apperley,Hugues deLavallade,Abdullah Alsuliman,Ahmad Khoder,David Marin,Edward Kanfer,Nichola Cooper,John Davis,Donald MacDonald,Marco Bua,Letizia Foroni,Chrissy Giles,Dragana Milojkovic,Amin Rahemtulla,Katayoun Rezvani
Vascular Biology
Correspondence
Errata
Other Departments
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Cover Image
Cover Image
![issue cover]()
In preparation for platelet production, megakaryocytes undergo multiple rounds of polyploidization, a process in which they duplicate their entire genome without undergoing cellular division, to attain greater than diploid content of DNA. The cover image shows an 8N mouse bone marrow megakaryocyte during anaphase. The cell was stained for mitotic regulator, survivin (red), α-tubulin (green) to visualize mitotic microtubules, and DAPI (blue) to stain nuclei. See the letter by McCrann and Ravid on page 2192.
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