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Issue Archive

Volume 115, Issue 2
January 14 2010
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
A Notch stairway to thymus?
Jean Plum
View Articletitled, A Notch stairway to thymus?
IMMUNOBIOLOGY
Monocytes tied to HIV-associated thrombosis
Liron Pantanowitz,Bruce J. Dezube
View Articletitled, Monocytes tied to HIV-associated thrombosis
PLATELETS & THROMBOPOIESIS
A bleeding disorder is born
David Varon
View Articletitled, A bleeding disorder is born
THROMBOSIS & HEMOSTASIS
aHUS: a disorder with many risk factors
Santiago Rodríguez de Córdoba
View Articletitled, aHUS: a disorder with many risk factors

PLENARY PAPERS

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
Nicholas T. Funderburg,Elizabeth Mayne,Scott F. Sieg,Robert Asaad,Wei Jiang,Magdalena Kalinowska,Angel A. Luciano,Wendy Stevens,Benigno Rodriguez,Jason M. Brenchley,Daniel C. Douek,Michael M. Lederman
View Articletitled, Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

REVIEW ARTICLES

International consensus report on the investigation and management of primary immune thrombocytopenia
Drew Provan,Roberto Stasi,Adrian C. Newland,Victor S. Blanchette,Paula Bolton-Maggs,James B. Bussel,Beng H. Chong,Douglas B. Cines,Terry B. Gernsheimer,Bertrand Godeau,John Grainger,Ian Greer,Beverley J. Hunt,Paul A. Imbach,Gordon Lyons,Robert McMillan,Francesco Rodeghiero,Miguel A. Sanz,Michael Tarantino,Shirley Watson,Joan Young,David J. Kuter
View Articletitled, International consensus report on the investigation and management of primary immune thrombocytopenia
Supplemental data

HOW I TREAT

How I treat CLL up front
John G. Gribben
View Articletitled, How I treat CLL up front

CLINICAL TRIALS AND OBSERVATIONS

Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias
Clinical Trials & Observations
Hans Beier Ommen,Susanne Schnittger,Jelena V. Jovanovic,Ingrid Beier Ommen,Henrik Hasle,Mette Østergaard,David Grimwade,Peter Hokland
View Articletitled, Strikingly different molecular relapse kinetics in <em>NPM1c</em>, <em>PML-RARA</em>, <em>RUNX1-RUNX1T1</em>, and <em>CBFB-MYH11</em> acute myeloid leukemias
Supplemental data
A population-based cytogenetic study of adults with acute lymphoblastic leukemia
Clinical Trials & Observations
Anthony V. Moorman,Lucy Chilton,Jennifer Wilkinson,Hannah M. Ensor,Nick Bown,Stephen J. Proctor
View Articletitled, A population-based cytogenetic study of adults with acute lymphoblastic leukemia
Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization
Clinical Trials & Observations
Julie Makani,Albert N. Komba,Sharon E. Cox,Julie Oruo,Khadija Mwamtemi,Jesse Kitundu,Pius Magesa,Stella Rwezaula,Elineema Meda,Josephine Mgaya,Kisali Pallangyo,Emelda Okiro,David Muturi,Charles R. Newton,Gregory Fegan,Kevin Marsh,Thomas N. Williams
View Articletitled, Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization

HEMATOPOIESIS AND STEM CELLS

MT1-MMP controls human mesenchymal stem cell trafficking and differentiation
Changlian Lu,Xiao-Yan Li,Yuexian Hu,R. Grant Rowe,Stephen J. Weiss
View Articletitled, MT1-MMP controls human mesenchymal stem cell trafficking and differentiation
Supplemental data
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene
Hiroshi Watarai,Andrei Rybouchkin,Naomi Hongo,Yuko Nagata,Sakura Sakata,Etsuko Sekine,Nyambayar Dashtsoodol,Takuya Tashiro,Shin-ichiro Fujii,Kanako Shimizu,Kenji Mori,Kyoko Masuda,Hiroshi Kawamoto,Haruhiko Koseki,Masaru Taniguchi
View Articletitled, Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant <em>Vα14-Jα18</em> TCRα gene
Supplemental data
Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4
Esther Carreras,Sean Turner,Mark Barton Frank,Nicholas Knowlton,Jeanette Osban,Michael Centola,Chae Gyu Park,Amie Simmons,José Alberola-Ila,Susan Kovats
View Articletitled, Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4
Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells
Holger Weishaupt,Mikael Sigvardsson,Joanne L. Attema
View Articletitled, Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells
Supplemental data
The AC133+CD38−, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures
Brief Report
Caryn Y. Ito,Daniel C. Kirouac,Gerard J. Madlambayan,Mei Yu,Ian Rogers,Peter W. Zandstra
View Articletitled, The AC133<sup>+</sup>CD38<sup>−</sup>, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures
Supplemental data
In vitro–differentiated T/natural killer–cell progenitors derived from human CD34+ cells mature in the thymus
Brief Report
Bob Meek,Silvie Cloosen,Chiara Borsotti,Catharina H. M. J. Van Elssen,Joris Vanderlocht,Melanie C. A. Schnijderberg,Marjolein W. M. van der Poel,Bas Leewis,Reinout Hesselink,Markus G. Manz,Yoshimoto Katsura,Hiroshi Kawamoto,Wilfred T. V. Germeraad,Gerard M. J. Bos
View Articletitled, In vitro–differentiated T/natural killer–cell progenitors derived from human CD34<sup>+</sup> cells mature in the thymus
Supplemental data
Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells
e-blood
Isao Kobayashi,Hiromasa Ono,Tadaaki Moritomo,Koichiro Kano,Teruyuki Nakanishi,Toshio Suda
View Articletitled, Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells
Supplemental data

IMMUNOBIOLOGY

An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
Graziella Curtale,Franca Citarella,Claudia Carissimi,Marina Goldoni,Nicoletta Carucci,Valerio Fulci,Debora Franceschini,Francesca Meloni,Vincenzo Barnaba,Giuseppe Macino
View Articletitled, An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
Supplemental data
CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets
Jianhua Yu,Hsiaoyin C. Mao,Min Wei,Tiffany Hughes,Jianying Zhang,Il-kyoo Park,Shujun Liu,Susan McClory,Guido Marcucci,Rossana Trotta,Michael A. Caligiuri
View Articletitled, CD94 surface density identifies a functional intermediary between the CD56<sup>bright</sup> and CD56<sup>dim</sup> human NK-cell subsets
Supplemental data
Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain
Daniel Corcos,Michael J. Osborn,Louise S. Matheson,Fatima Santos,Xiangang Zou,Jennifer A. Smith,Geoff Morgan,Amanda Hutchings,Maureen Hamon,David Oxley,Marianne Brüggemann
View Articletitled, Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain
Supplemental data

LYMPHOID NEOPLASIA

The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation
Pedro Farinha,Abdulwahab Al-Tourah,Karamjit Gill,Richard Klasa,Joseph M. Connors,Randy D. Gascoyne
View Articletitled, The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation
Differential genome-wide array–based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
Meena Kanduri,Nicola Cahill,Hanna Göransson,Camilla Enström,Fergus Ryan,Anders Isaksson,Richard Rosenquist
View Articletitled, Differential genome-wide array–based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
Bing Z. Carter,Duncan H. Mak,Wendy D. Schober,Erich Koller,Clemencia Pinilla,Lyubomir T. Vassilev,John C. Reed,Michael Andreeff
View Articletitled, Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
Supplemental data
A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib
Shannon K. McWeeney,Lucy C. Pemberton,Marc M. Loriaux,Kristina Vartanian,Stephanie G. Willis,Gregory Yochum,Beth Wilmot,Yaron Turpaz,Raji Pillai,Brian J. Druker,Jennifer L. Snead,Mary MacPartlin,Stephen G. O'Brien,Junia V. Melo,Thoralf Lange,Christina A. Harrington,Michael W. N. Deininger
View Articletitled, A gene expression signature of CD34<sup>+</sup> cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib
Supplemental data
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia
Brief Report
Ashley N. Mays,Neil Osheroff,Yuanyuan Xiao,Joseph L. Wiemels,Carolyn A. Felix,Jo Ann W. Byl,Kandeepan Saravanamuttu,Andrew Peniket,Robert Corser,Cherry Chang,Christine Hoyle,Anne N. Parker,Syed K. Hasan,Francesco Lo-Coco,Ellen Solomon,David Grimwade
View Articletitled, Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia
Supplemental data
Heterozygous deletion of the PU.1 locus in human AML
Brief Report
Nicola Bonadies,Thomas Pabst,Beatrice U. Mueller
View Articletitled, Heterozygous deletion of the PU.1 locus in human AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Evidence for a cross-talk between human neutrophils and Th17 cells
Martin Pelletier,Laura Maggi,Alessandra Micheletti,Elena Lazzeri,Nicola Tamassia,Claudio Costantini,Lorenzo Cosmi,Claudio Lunardi,Francesco Annunziato,Sergio Romagnani,Marco A. Cassatella
View Articletitled, Evidence for a cross-talk between human neutrophils and Th17 cells
Supplemental data
Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
Anissa M. Jabbour,Carmel P. Daunt,Benjamin D. Green,Sandra Vogel,Lavinia Gordon,Rachel S. Lee,Natasha Silke,Richard B. Pearson,Cassandra J. Vandenberg,Priscilla N. Kelly,Stephen L. Nutt,Andreas Strasser,Christoph Borner,Paul G. Ekert
View Articletitled, Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
Supplemental data
Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
Audrey Varin,Subhankar Mukhopadhyay,Georges Herbein,Siamon Gordon
View Articletitled, Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
Supplemental data

PLATELETS AND THROMBOPOIESIS

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis
Andrew D. Mumford,Ban B. Dawood,Martina E. Daly,Sherina L. Murden,Michael D. Williams,Majd B. Protty,Jennifer C. Spalton,Mark Wheatley,Stuart J. Mundell,Steve P. Watson
View Articletitled, A novel thromboxane A<sub>2</sub> receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

THROMBOSIS AND HEMOSTASIS

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13
Tao Wu,Jiangguo Lin,Miguel A. Cruz,Jing-fei Dong,Cheng Zhu
View Articletitled, Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13
Supplemental data
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
Iain Moore,Lisa Strain,Isabel Pappworth,David Kavanagh,Paul N. Barlow,Andrew P. Herbert,Christoph Q. Schmidt,Scott J. Staniforth,Lucy V. Holmes,Roy Ward,Lynn Morgan,Timothy H. J. Goodship,Kevin J. Marchbank
View Articletitled, Association of factor H autoantibodies with deletions of <em>CFHR1</em>, <em>CFHR3</em>, <em>CFHR4</em>, and with mutations in <em>CFH</em>, <em>CFI</em>, <em>CD46</em>, and <em>C3</em> in patients with atypical hemolytic uremic syndrome
Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome
Jildou Hoekstra,Ana H. C. Guimarães,Frank W. G. Leebeek,Sarwa Darwish Murad,Joyce J. M. C. Malfliet,Aurelie Plessier,Manuel Hernandez-Guerra,Philippe Langlet,Elwyn Elias,Jonel Trebicka,Massimo Primignani,Juan-Carlos Garcia-Pagan,Dominique C. Valla,Dingeman C. Rijken,Harry L. A. Janssen,for the European Network for Vascular Disorders of the Liver (EN-Vie)
View Articletitled, Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome
Supplemental data

TRANSPLANTATION

Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy
Sujith Samarasinghe,Christoph Mancao,Martin Pule,Niga Nawroly,Helen Karlsson,Jennifer Brewin,Peter Openshaw,H. Bobby Gaspar,Paul Veys,Persis J. Amrolia
View Articletitled, Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy
Supplemental data
Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment
Amanda Waterstrat,Ying Liang,Carol F. Swiderski,Brent J. Shelton,Gary Van Zant
View Articletitled, Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment
Supplemental data

VASCULAR BIOLOGY

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1
Michael J. Flister,Andrew Wilber,Kelly L. Hall,Caname Iwata,Kohei Miyazono,Riccardo E. Nisato,Michael S. Pepper,David C. Zawieja,Sophia Ran
View Articletitled, Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1
Supplemental data

CORRESPONDENCE

Toxicity of laromustine plus high-dose cytarabine in patients with relapsed acute myeloid leukemia
Albert Deisseroth,Ann Farrell,Robert Justice,Robert Kane,Rajeshwari Sridhara,Huanyu Chen,Kun He,Richard Pazdur
View Articletitled, Toxicity of laromustine plus high-dose cytarabine in patients with relapsed acute myeloid leukemia
Activated cryptic granulocyte-macrophage colony-stimulating factor autoantibodies in intravenous immunoglobulin preparations
Renée Bazin,Isabelle St-Amour,André Laroche,Réal Lemieux
View Articletitled, Activated cryptic granulocyte-macrophage colony-stimulating factor autoantibodies in intravenous immunoglobulin preparations
Response: Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons
Kanji Uchida,Brenna Carey,Takuji Suzuki,Koh Nakata,Bruce Trapnell
View Articletitled, Response: Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons
Are neutralizing anti–GM-CSF autoantibodies present in all healthy persons?
Anthony Meager,Isabelle Cludts,Robin Thorpe,Meenu Wadhwa
View Articletitled, Are neutralizing anti–GM-CSF autoantibodies present in all healthy persons?
Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease
Jakub Tolar,Mary Eapen,Paul J. Orchard,Bruce R. Blazar
View Articletitled, Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease
Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients
Richard Kolesnick,Marcel van den Brink,Glenn Heller,Jimmy A. Rotolo
View Articletitled, Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients
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