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INSIDE BLOOD

INSIDE BLOOD
MYELOID NEOPLASIA
MYELOID NEOPLASIA
VASCULAR BIOLOGY

REVIEW ARTICLES

CLINICAL TRIALS AND OBSERVATIONS

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

TRANSPLANTATION

VASCULAR BIOLOGY

CORRESPONDENCE

RETRACTIONS

  • Cover Image

    Cover Image

    issue cover

    Osteoclasts are the cells responsible for bone resorption and are derived from hematopoietic stem cells. The cover shows an image of an osteoclast generated on a mineralized dentine substrate by directed differentiation of human-induced pluripotent stem cells through a defined sequence of mesoderm induction, hematopoiesis specification, myeloid cell expansion, and differentiation to osteoclasts. The confocal image depicts the osteoclast associated with a resorption pit (not shown) expressing the marker protein β3 integrin (green), formation of an F-actin ring (red), and secretion the cysteine protease cathepsin K (blue), which are characteristic features of actively resorbing osteoclasts. See the article by Grigoriadis et al on page 2769.

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