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Issue Archive

Volume 114, Issue 9
August 27 2009
Issue Cover

Table of Contents

INSIDE BLOOD

MYELOID NEOPLASIA
Decatenation: fixing your knots
Duncan J. Clarke
View Articletitled, Decatenation: fixing your knots
PLATELETS & THROMBOPOIESIS
The clot thickens (or not)
Steven E. McKenzie,Michael P. Reilly
View Articletitled, The clot thickens (or not)
PLATELETS & THROMBOPOIESIS
GPVI: the inside story
Alan Nurden
View Articletitled, GPVI: the inside story
TRANSFUSION MEDICINE
Processed platelet HPA1a peptides au naturel
John W. Semple
View Articletitled, Processed platelet HPA1a peptides au naturel
TRANSPLANTATION
Expanding multiviral reactive T cells from cord blood
Richard W. Childs,Christa S. Zerbe
View Articletitled, Expanding multiviral reactive T cells from cord blood
VASCULAR BIOLOGY
The antitumorigenic trifecta
Yvonne M. Mowery,Salvatore V. Pizzo
View Articletitled, The antitumorigenic trifecta

PERSPECTIVE

Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens
Shaji Kumar,Sergio Giralt,Edward A. Stadtmauer,Jean L. Harousseau,Antonio Palumbo,William Bensinger,Raymond L. Comenzo,Suzanne Lentzsch,Nikhil Munshi,Ruben Niesvizky,Jesus San Miguel,Heinz Ludwig,Leif Bergsagel,Joan Blade,Sagar Lonial,Kenneth C. Anderson,Patrizia Tosi,Pieter Sonneveld,Orhan Sezer,David Vesole,Michele Cavo,Hermann Einsele,Paul G. Richardson,Brian G. M. Durie,S. Vincent Rajkumar,on behalf of the International Myeloma Working Group (IMWG)
View Articletitled, Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens

CLINICAL TRIALS AND OBSERVATIONS

Granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)
Clinical Trials & Observations
Ivan M. Borrello,Hyam I. Levitsky,Wendy Stock,Dorie Sher,Lu Qin,Daniel J. DeAngelo,Edwin P. Alyea,Richard M. Stone,Lloyd E. Damon,Charles A. Linker,Daniel J. Maslyar,Kristen M. Hege
View Articletitled, Granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)
Supplemental data
A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia
Clinical Trials & Observations
Nina S. Kadan-Lottick,Pim Brouwers,David Breiger,Thomas Kaleita,James Dziura,Haibei Liu,Lu Chen,Megan Nicoletti,Linda Stork,Bruce Bostrom,Joseph P. Neglia
View Articletitled, A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression
Linda Marie Starnes,Antonio Sorrentino,Elvira Pelosi,Monica Ballarino,Ornella Morsilli,Mauro Biffoni,Simona Santoro,Nadia Felli,Germana Castelli,Maria Laura De Marchis,Gianfranco Mastroberardino,Marco Gabbianelli,Alessandro Fatica,Irene Bozzoni,Clara Nervi,Cesare Peschle
View Articletitled, NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression
Supplemental data
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency
Brief Report
Motohito Okabe,Makoto Otsu,Dong Hyuck Ahn,Toshihiro Kobayashi,Yohei Morita,Yukiko Wakiyama,Masafumi Onodera,Koji Eto,Hideo Ema,Hiromitsu Nakauchi
View Articletitled, Definitive proof for direct reprogramming of hematopoietic cells to pluripotency
Supplemental data

IMMUNOBIOLOGY

Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells
Yoshinori Katayama,Miho Sekai,Masakazu Hattori,Ichiro Miyoshi,Yoko Hamazaki,Nagahiro Minato
View Articletitled, Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination
Christopher A. Klebanoff,Zhiya Yu,Leroy N. Hwang,Douglas C. Palmer,Luca Gattinoni,Nicholas P. Restifo
View Articletitled, Programming tumor-reactive effector memory CD8<sup>+</sup> T cells in vitro obviates the requirement for in vivo vaccination
Supplemental data
Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development
Armelle Le Campion,Marie-Claude Gagnerault,Cédric Auffray,Chantal Bécourt,Maud Poitrasson-Rivière,Eliette Lallemand,Boris Bienvenu,Bruno Martin,Françoise Lepault,Bruno Lucas
View Articletitled, Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development
Supplemental data
TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
Jérémy Di Domizio,Ariane Blum,Maighread Gallagher-Gambarelli,Jean-Paul Molens,Laurence Chaperot,Joël Plumas
View Articletitled, TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
Supplemental data

LYMPHOID NEOPLASIA

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth
Angela Pennisi,Wen Ling,Xin Li,Sharmin Khan,John D. Shaughnessy, Jr,Bart Barlogie,Shmuel Yaccoby
View Articletitled, The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth
Supplemental data

MYELOID NEOPLASIA

BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair
Margret S. Fernandes,Mamatha M. Reddy,Jeffrey R. Gonneville,Scott C. DeRoo,Klaus Podar,James D. Griffin,David M. Weinstock,Martin Sattler
View Articletitled, BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair
Supplemental data
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling
Andrew D. Wood,Edwin Chen,Ian J. Donaldson,Shilpa Hattangadi,Karly A. Burke,Mark A. Dawson,Diego Miranda-Saavedra,Harvey F. Lodish,Anthony R. Green,Berthold Göttgens
View Articletitled, ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling
Supplemental data
Enrichment of Sca1+ hematopoietic progenitors in polycythemic mice inhibits leukemogenesis
Tatiana Usenko,You-Jun Li,Mehran Haeri,Yanmei Li,Laura M. Vecchiarelli-Federico,Xiaojun Zhao,Josef T. Prchal,Yaacov Ben-David
View Articletitled, Enrichment of Sca1<sup>+</sup> hematopoietic progenitors in polycythemic mice inhibits leukemogenesis
Supplemental data
Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines
Abire Jedidi,Caroline Marty,Charleen Oligo,Laurence Jeanson-Leh,Jean-Antoine Ribeil,Nicole Casadevall,Anne Galy,William Vainchenker,Jean-Luc Villeval
View Articletitled, Selective reduction of JAK2<sup>V617F</sup>-dependent cell growth by siRNA/shRNA and its reversal by cytokines
Metnase mediates chromosome decatenation in acute leukemia cells
Justin Wray,Elizabeth A. Williamson,Sheema Sheema,Suk-Hee Lee,Edward Libby,Cheryl L. Willman,Jac A. Nickoloff,Robert Hromas
View Articletitled, Metnase mediates chromosome decatenation in acute leukemia cells
Supplemental data
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
Brief Report
Mignon L. Loh,Debbie S. Sakai,Christian Flotho,Michelle Kang,Manfred Fliegauf,Sophie Archambeault,Charles G. Mullighan,Leslie Chen,Eva Bergstraesser,Carlos E. Bueso-Ramos,Peter D. Emanuel,Henrik Hasle,Jean-Pierre Issa,Marry M. van den Heuvel-Eibrink,Franco Locatelli,Jan Starý,Monica Trebo,Marcin Wlodarski,Marco Zecca,Kevin M. Shannon,Charlotte M. Niemeyer
View Articletitled, Mutations in <em>CBL</em> occur frequently in juvenile myelomonocytic leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon
Teresa Greenwell-Wild,Nancy Vázquez,Wenwen Jin,Zoila Rangel,Peter J. Munson,Sharon M. Wahl
View Articletitled, Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon
Supplemental data

PLATELETS AND THROMBOPOIESIS

Exposure of human megakaryocytes to high shear rates accelerates platelet production
Claire Dunois-Lardé,Claude Capron,Serge Fichelson,Thomas Bauer,Elisabeth Cramer-Bordé,Dominique Baruch
View Articletitled, Exposure of human megakaryocytes to high shear rates accelerates platelet production
Supplemental data
The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo
Marie-Pierre Gratacap,Valérie Martin,Marie-Cécile Valéra,Sophie Allart,Cédric Garcia,Pierre Sié,Christian Recher,Bernard Payrastre
View Articletitled, The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo
Supplemental data
The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding
Elisabetta Trifiro,Shirley A. Williams,Yann Cheli,Kenichi Furihata,Fabio M. Pulcinelli,Diane J. Nugent,Thomas J. Kunicki
View Articletitled, The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding
Supplemental data
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
Brief Report
Bénédicte Dumont,Dominique Lasne,Chantal Rothschild,Maxime Bouabdelli,Véronique Ollivier,Claire Oudin,Nadine Ajzenberg,Bernard Grandchamp,Martine Jandrot-Perrus
View Articletitled, Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion
William A. Anong,Taina Franco,Haiyan Chu,Tahlia L. Weis,Emily E. Devlin,David M. Bodine,Xiuli An,Narla Mohandas,Philip S. Low
View Articletitled, Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion
Supplemental data
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
Curry L. Koening,Jennifer C. Miller,Jenifer M. Nelson,Diane M. Ward,James P. Kushner,Linda K. Bockenstedt,Janis J. Weis,Jerry Kaplan,Ivana De Domenico
View Articletitled, Toll-like receptors mediate induction of hepcidin in mice infected with <em>Borrelia burgdorferi</em>
Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3
Kate Hsu,Naiwen Chi,Marjan Gucek,Jennifer E. Van Eyk,Robert N. Cole,Marie Lin,D. Brian Foster
View Articletitled, Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3
Supplemental data

THROMBOSIS AND HEMOSTASIS

High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension
Timothy A. Morris,James J. Marsh,Peter G. Chiles,Marisa M. Magaña,Ni-Cheng Liang,Xavier Soler,Daniel J. DeSantis,Debby Ngo,Virgil L. Woods, Jr
View Articletitled, High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension
Supplemental data
A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury
Andre L. Samson,Rachael J. Borg,Be'eri Niego,Connie H. Y. Wong,Peter J. Crack,Tang Yongqing,Robert L. Medcalf
View Articletitled, A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury
Supplemental data
Fibrinogen α and γ genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies
Ulrike Nowak-Göttl,Hartmut Weiler,Irene Hernandez,Sabine Thedieck,Tanja Seehafer,Thomas Schulte,Monika Stoll
View Articletitled, Fibrinogen α and γ genes and factor V<sup>Leiden</sup> in children with thromboembolism: results from 2 family-based association studies

TRANSFUSION MEDICINE

Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101–positive antigen-presenting cells
Brief Report
Gholamreza Anani Sarab,Michael Moss,Robert N. Barker,Stanislaw J. Urbaniak
View Articletitled, Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101–positive antigen-presenting cells

TRANSPLANTATION

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes
Patrick J. Hanley,Conrad Russell Young Cruz,Barbara Savoldo,Ann M. Leen,Maja Stanojevic,Mariam Khalil,William Decker,Jeffrey J. Molldrem,Hao Liu,Adrian P. Gee,Cliona M. Rooney,Helen E. Heslop,Gianpietro Dotti,Malcolm K. Brenner,Elizabeth J. Shpall,Catherine M. Bollard
View Articletitled, Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

VASCULAR BIOLOGY

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement
Geerte L. Van Sluis,Tatjana M.H. Niers,Charles T. Esmon,Wikky Tigchelaar,Dick J. Richel,Harry R. Buller,Cornelis J.F. Van Noorden,C. Arnold Spek
View Articletitled, Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement
Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
Ramesh C. Nayak,Prosenjit Sen,Samit Ghosh,Ramakrishnan Gopalakrishnan,Charles T. Esmon,Usha R. Pendurthi,L. Vijaya Mohan Rao
View Articletitled, Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
Supplemental data
Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins
Tong-Young Lee,Stefan Muschal,Elke A. Pravda,Judah Folkman,Amir Abdollahi,Kashi Javaherian
View Articletitled, Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins
Supplemental data

CORRESPONDENCE

Intrathecal MTX for DLBCL: from an inappropriate prophylactic tradition to a medical error?
Pierre-Yves Dietrich
View Articletitled, Intrathecal MTX for DLBCL: from an inappropriate prophylactic tradition to a medical error?
Response:Intrathecal methotrexate and central nervous system events
Norbert Schmitz,Samira Zeynalova,Markus Loeffler,Michael Pfreundschuh,German High Grade Lymphoma Study Group
View Articletitled, Response:Intrathecal methotrexate and central nervous system events
Consistency and synergy
M. Jane Teta,Meghan E. Wagner
View Articletitled, Consistency and synergy
Response:Malignant mesothelioma after irradiation: consistency and synergy
Jacobus A. Burgers,Marieke L. De Bruin,Paul Baas,Floor van Leeuwen
View Articletitled, Response:Malignant mesothelioma after irradiation: consistency and synergy
Selective accumulation of virus-specific CD8+ T cells within the peripheral blood stem cell compartment
Sanjleena Singh,Paulien van Hauten,Kimberley Jones,Karen Grimmett,Anthony K. Mills,Maher K. Gandhi
View Articletitled, Selective accumulation of virus-specific CD8<sup>+</sup> T cells within the peripheral blood stem cell compartment
Antinuclear antibody (ANA)–positive thrombocytopenia: primary, but with a difference
Alberto M. Marmont
View Articletitled, Antinuclear antibody (ANA)–positive thrombocytopenia: primary, but with a difference
Response:Immune thrombocytopenic purpura: terminology and definitions
Francesco Rodeghiero,Marco Ruggeri,on behalf of the International Working Group
View Articletitled, Response:Immune thrombocytopenic purpura: terminology and definitions

ERRATUM

Jiang et al. Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors. Blood. 2000;95(3):846-854.
View Articletitled, Jiang et al. Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors. <em>Blood</em>. 2000;95(3):846-854.
  • Cover Image

    Cover Image

    issue cover

    When Topo IIα is inhibited without DNA damage, all cells should arrest before mitosis because chromosome decatenation is halted. However, as shown on the cover, AML cells progress through decatenation even when Topo IIα is inhibited, and fail to arrest at mitosis (indicated by a lack of red MPM-2–positive cells). This occurs because they overexpress Metnase, which enhances Topo IIα function, and promotes decatenation. This allows AML cells to progress through mitosis even when Topo IIα is inhibited. See the article by Wray et al on page 1852.

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