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Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network
Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Issue Archive
July 16 2009
Table of Contents
INSIDE BLOOD
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network
Clinical Trials & Observations
Amin M. Alousi,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Daniel J. Weisdorf,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Brent R. Logan,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Javier Bolaños-Meade,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Shelly Carter,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Nancy DiFronzo,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Marcelo Pasquini,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Steven C. Goldstein,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Vincent T. Ho,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Brandon Hayes-Lattin,on behalf of the Blood and Marrow Transplant Clinical Trials Network,John R. Wingard,on behalf of the Blood and Marrow Transplant Clinical Trials Network,Mary M. Horowitz,on behalf of the Blood and Marrow Transplant Clinical Trials Network,John E. Levine,on behalf of the Blood and Marrow Transplant Clinical Trials Network
Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
Brief Report
Prashant Kapoor,Shaji Kumar,Rafael Fonseca,Martha Q. Lacy,Thomas E. Witzig,Suzanne R. Hayman,Angela Dispenzieri,Francis Buadi,P. Leif Bergsagel,Morie A. Gertz,Robert J. Dalton,Joseph R. Mikhael,David Dingli,Craig B. Reeder,John A. Lust,Stephen J. Russell,Vivek Roy,Steven R. Zeldenrust,A. Keith Stewart,Robert A. Kyle,Philip R. Greipp,S. Vincent Rajkumar
Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13
Brief Report
Donna Reece,Kevin W. Song,Tommy Fu,Birgitte Roland,Hong Chang,Douglas E. Horsman,Adnan Mansoor,Christine Chen,Esther Masih-Khan,Young Trieu,Helene Bruyere,Douglas A. Stewart,Nizar J. Bahlis
GENE THERAPY
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
Laura A. Johnson,Richard A. Morgan,Mark E. Dudley,Lydie Cassard,James C. Yang,Marybeth S. Hughes,Udai S. Kammula,Richard E. Royal,Richard M. Sherry,John R. Wunderlich,Chyi-Chia R. Lee,Nicholas P. Restifo,Susan L. Schwarz,Alexandria P. Cogdill,Rachel J. Bishop,Hung Kim,Carmen C. Brewer,Susan F. Rudy,Carter VanWaes,Jeremy L. Davis,Aarti Mathur,Robert T. Ripley,Debbie A. Nathan,Carolyn M. Laurencot,Steven A. Rosenberg
IMMUNOBIOLOGY
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Nana Ueffing,Kusum K. Singh,Andrea Christians,Christoph Thorns,Alfred C. Feller,Florian Nagl,Falko Fend,Sebastian Heikaus,Alexander Marx,Rainer B. Zotz,Joachim Brade,Wolfgang A. Schulz,Klaus Schulze-Osthoff,Ingo Schmitz,Christian Schwerk
LYMPHOID NEOPLASIA
RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma
Abdel Kareem Azab,Feda Azab,Simona Blotta,Costas M. Pitsillides,Brian Thompson,Judith M. Runnels,Aldo M. Roccaro,Hai T. Ngo,Molly R. Melhem,Antonio Sacco,Xiaoying Jia,Kenneth C. Anderson,Charles P. Lin,Barrett J. Rollins,Irene M. Ghobrial
Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases
Ilaria Del Giudice,Sabina Chiaretti,Simona Tavolaro,Maria Stefania De Propris,Roberta Maggio,Francesca Mancini,Nadia Peragine,Simona Santangelo,Marilisa Marinelli,Francesca Romana Mauro,Anna Guarini,Robin Foà
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
Brief Report
Alejandro Gutierrez,Takaomi Sanda,Ruta Grebliunaite,Arkaitz Carracedo,Leonardo Salmena,Yebin Ahn,Suzanne Dahlberg,Donna Neuberg,Lisa A. Moreau,Stuart S. Winter,Richard Larson,Jianhua Zhang,Alexei Protopopov,Lynda Chin,Pier Paolo Pandolfi,Lewis B. Silverman,Stephen P. Hunger,Stephen E. Sallan,A. Thomas Look
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Brief Report
Simone M. Schoenwaelder,Yuping Yuan,Emma C. Josefsson,Michael J. White,Yu Yao,Kylie D. Mason,Lorraine A. O'Reilly,Katya J. Henley,Akiko Ono,Sarah Hsiao,Abbey Willcox,Andrew W. Roberts,David C. S. Huang,Hatem H. Salem,Benjamin T. Kile,Shaun P. Jackson
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells
Hideto Matsui,Masaru Shibata,Brian Brown,Andrea Labelle,Carol Hegadorn,Chandler Andrews,Marinee Chuah,Thierry VandenDriessche,Carol H. Miao,Christine Hough,David Lillicrap
TRANSPLANTATION
Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming
Steven L. Highfill,Ryan M. Kelly,Matthew J. O'Shaughnessy,Qing Zhou,Lily Xia,Angela Panoskaltsis-Mortari,Patricia A. Taylor,Jakub Tolar,Bruce R. Blazar
VASCULAR BIOLOGY
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Marianna Prokopi,Giordano Pula,Ursula Mayr,Cécile Devue,Joy Gallagher,Qingzhong Xiao,Chantal M. Boulanger,Nigel Westwood,Carmen Urbich,Johann Willeit,Marianne Steiner,Johannes Breuss,Qingbo Xu,Stefan Kiechl,Manuel Mayr
CORRESPONDENCE
Proportions of immature CD19+CD21− B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host disease
Zoya Kuzmina,Hildegard T. Greinix,Robert Knobler,Nina Worel,Michal Kouba,Roman Weigl,Ulrike Körmöczi,Arno Rottal,David Pohlreich,Christoph Zielinski,Winfried F. Pickl
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Cover Image
Cover Image
The Australian Common Brown Snake (Pseudonaja textilis) has one of the most toxic venoms in the world, containing neurotoxic and procoagulant components. The latter consists of a factor V and a factor Xa-like enzyme. The factor V component has unique gain-of-function properties not present in mammalian factor V. See the article by Bos et al on page 686. Photo kindly provided by Professor Christopher Pollitt, University of Queensland School of Veterinary Science, Brisbane, Australia.
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