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Issue Archive

Volume 114, Issue 20
November 12 2009
Issue Cover

Table of Contents

INSIDE BLOOD

PLATELETS & THROMBOPOIESIS
Platelet CFH: in search of the source
Jan Willem N. Akkerman
View Articletitled, Platelet CFH: in search of the source
INSIDE BLOOD
Hunting for the Achilles' heel of CLL
John C. Byrd
View Articletitled, Hunting for the Achilles' heel of CLL
RED CELLS & IRON
Mining ferritin iron: 2 pathways
Elizabeth C. Theil
View Articletitled, Mining ferritin iron: 2 pathways

REVIEW ARTICLES

Acute graft-versus-host disease: from the bench to the bedside
Gerard Socié,Bruce R. Blazar
View Articletitled, Acute graft-versus-host disease: from the bench to the bedside

HOW I TREAT

How I treat mycosis fungoides and Sézary syndrome
H. Miles Prince,Sean Whittaker,Richard T. Hoppe
View Articletitled, How I treat mycosis fungoides and Sézary syndrome

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study
Clinical Trials & Observations
David A. Jacobsohn,Andrew L. Gilman,Alfred Rademaker,Brittan Browning,Michael Grimley,Leslie Lehmann,Eneida R. Nemecek,Kimberly Thormann,Kirk R. Schultz,Georgia B. Vogelsang
View Articletitled, Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study
Supplemental data
The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-up
Clinical Trials & Observations
Ravin J. Garg,Hagop Kantarjian,Susan O'Brien,Alfonso Quintás-Cardama,Stefan Faderl,Zeev Estrov,Jorge Cortes
View Articletitled, The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-up
The persistence of immunophenotypically normal residual bone marrow plasma cells at diagnosis identifies a good prognostic subgroup of symptomatic multiple myeloma patients
Brief Report
Bruno Paiva,Maria-Belén Vidriales,Gema Mateo,Jose J. Pérez,Maria Angeles Montalbán,Anna Sureda,Laura Montejano,Norma C. Gutiérrez,Alfonso García de Coca,Natalia de las Heras,Maria Victoria Mateos,Maria Consuelo López-Berges,Raimundo García-Boyero,Josefina Galende,Jose Hernández,Luis Palomera,Dolores Carrera,Rafael Martínez,Javier de la Rubia,Alejandro Martín,Yolanda González,Joan Bladé,Juan José Lahuerta,Alberto Orfao,Jesús F. San-Miguel,on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Groups
View Articletitled, The persistence of immunophenotypically normal residual bone marrow plasma cells at diagnosis identifies a good prognostic subgroup of symptomatic multiple myeloma patients

GENE THERAPY

Anti-CD3 antibodies modulate anti–factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy
Baowei Peng,Peiqing Ye,David J. Rawlings,Hans D. Ochs,Carol H. Miao
View Articletitled, Anti-CD3 antibodies modulate anti–factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration
Yasushi Kubota,Masatake Osawa,Lars Martin Jakt,Kazuaki Yoshikawa,Shin-Ichi Nishikawa
View Articletitled, Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration
Supplemental data
BMP4 regulates the hematopoietic stem cell niche
Devorah C. Goldman,Alexis S. Bailey,Dana L. Pfaffle,Azzah Al Masri,Jan L. Christian,William H. Fleming
View Articletitled, BMP4 regulates the hematopoietic stem cell niche
Supplemental data
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model
Yunglin D. Ma,Changwon Park,Haibo Zhao,Kwadwo A. Oduro, Jr,Xiaolin Tu,Fanxin Long,Paul M. Allen,Steven L. Teitelbaum,Kyunghee Choi
View Articletitled, Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model
Supplemental data

IMMUNOBIOLOGY

Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop
Kristin Hochweller,Tewfik Miloud,Jörg Striegler,Shalin Naik,Günter J. Hämmerling,Natalio Garbi
View Articletitled, Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop
Supplemental data
CD56+ human blood dendritic cells effectively promote TH1-type γδ T-cell responses
Georg Gruenbacher,Hubert Gander,Andrea Rahm,Walter Nussbaumer,Nikolaus Romani,Martin Thurnher
View Articletitled, CD56<sup>+</sup> human blood dendritic cells effectively promote T<sub>H</sub>1-type γδ T-cell responses
The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells
Morgan Taillardet,Ghina Haffar,Paul Mondière,Marie-Jeanne Asensio,Hanane Gheit,Nicolas Burdin,Thierry Defrance,Laurent Genestier
View Articletitled, The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells
Supplemental data

LYMPHOID NEOPLASIA

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
Antonina V. Kurtova,Kumudha Balakrishnan,Rong Chen,Wei Ding,Susanne Schnabl,Maite P. Quiroga,Mariela Sivina,William G. Wierda,Zeev Estrov,Michael J. Keating,Medhat Shehata,Ulrich Jäger,Varsha Gandhi,Neil E. Kay,William Plunkett,Jan A. Burger
View Articletitled, Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
Supplemental data
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia
Emmanuel J. Volanakis,Richard T. Williams,Charles J. Sherr
View Articletitled, Stage-specific <em>Arf</em> tumor suppression in <em>Notch1</em>-induced T-cell acute lymphoblastic leukemia
Supplemental data
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Lesley-Ann Sutton,Efterpi Kostareli,Anastasia Hadzidimitriou,Nikos Darzentas,Athanasios Tsaftaris,Achilles Anagnostopoulos,Richard Rosenquist,Kostas Stamatopoulos
View Articletitled, Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Supplemental data
Chronic lymphocytic leukemia of Eμ-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
Thomas Enzler,Arnon P. Kater,Weizhou Zhang,George F. Widhopf, II,Han-Yu Chuang,Jason Lee,Esther Avery,Carlo M. Croce,Michael Karin,Thomas J. Kipps
View Articletitled, Chronic lymphocytic leukemia of Eμ-<em>TCL1</em> transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
Supplemental data
Generation of CD8+ T cell–mediated immunity against idiotype-negative lymphoma escapees
Bindu Varghese,Adam Widman,James Do,Behnaz Taidi,Debra K. Czerwinski,John Timmerman,Shoshana Levy,Ronald Levy
View Articletitled, Generation of CD8<sup>+</sup> T cell–mediated immunity against idiotype-negative lymphoma escapees
Gene expression–based classification and regulatory networks of pediatric acute lymphoblastic leukemia
Zhigang Li,Wei Zhang,Minyuan Wu,Shanshan Zhu,Chao Gao,Lin Sun,Ruidong Zhang,Nan Qiao,Huiling Xue,Yamei Hu,Shilai Bao,Huyong Zheng,Jing-Dong J. Han
View Articletitled, Gene expression–based classification and regulatory networks of pediatric acute lymphoblastic leukemia
Supplemental data
A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display
Sivasubramanian Baskar,Jessica M. Suschak,Ivan Samija,Ramaprasad Srinivasan,Richard W. Childs,Steven Z. Pavletic,Michael R. Bishop,Christoph Rader
View Articletitled, A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display
Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities
Brief Report
Anja Mottok,Christoph Renné,Marc Seifert,Elsie Oppermann,Wolf Bechstein,Martin-Leo Hansmann,Ralf Küppers,Andreas Bräuninger
View Articletitled, Inactivating <em>SOCS1</em> mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities

MYELOID NEOPLASIA

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways
Mohamed Rahmani,Anh Anderson,Joseph Reza Habibi,Timothy Ryan Crabtree,Mandy Mayo,Hisashi Harada,Andrea Ferreira-Gonzalez,Paul Dent,Steven Grant
View Articletitled, The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)
Masahiro Hiasa,Masahiro Abe,Ayako Nakano,Asuka Oda,Hiroe Amou,Shinsuke Kido,Kyoko Takeuchi,Kumiko Kagawa,Kenichiro Yata,Toshihiro Hashimoto,Shuji Ozaki,Kenzo Asaoka,Eiji Tanaka,Keiji Moriyama,Toshio Matsumoto
View Articletitled, GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)
Supplemental data
The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
Kathleen Szczur,Yi Zheng,Marie-Dominique Filippi
View Articletitled, The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet-associated complement factor H in healthy persons and patients with atypical HUS
Christoph Licht,Fred G. Pluthero,Ling Li,Hilary Christensen,Sandra Habbig,Bernd Hoppe,Denis F. Geary,Peter F. Zipfel,Walter H. A. Kahr
View Articletitled, Platelet-associated complement factor H in healthy persons and patients with atypical HUS

RED CELLS, IRON, AND ERYTHROPOIESIS

Specific iron chelators determine the route of ferritin degradation
Ivana De Domenico,Diane McVey Ward,Jerry Kaplan
View Articletitled, Specific iron chelators determine the route of ferritin degradation
Supplemental data

THROMBOSIS AND HEMOSTASIS

The therapeutic effect of bone marrow–derived liver cells in the phenotypic correction of murine hemophilia A
Neelam Yadav,Sumod Kanjirakkuzhiyil,Suresh Kumar,Manish Jain,Ashutosh Halder,Renu Saxena,Asok Mukhopadhyay
View Articletitled, The therapeutic effect of bone marrow–derived liver cells in the phenotypic correction of murine hemophilia A
Supplemental data
Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model
Brief Report
Denise E. Sabatino,Christian Furlan Freguia,Raffaella Toso,Andrey Santos,Elizabeth P. Merricks,Haig H. Kazazian, Jr,Timothy C. Nichols,Rodney M. Camire,Valder R. Arruda
View Articletitled, Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model
Supplemental data

TRANSPLANTATION

Bone marrow as an alternative site for islet transplantation
Elisa Cantarelli,Raffaella Melzi,Alessia Mercalli,Valeria Sordi,Giuliana Ferrari,Carsten Werner Lederer,Emanuela Mrak,Alessandro Rubinacci,Maurilio Ponzoni,Giovanni Sitia,Luca G. Guidotti,Ezio Bonifacio,Lorenzo Piemonti
View Articletitled, Bone marrow as an alternative site for islet transplantation
Supplemental data
Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease
Niklas Beyersdorf,Xin Ding,Thomas Hünig,Thomas Kerkau
View Articletitled, Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease
Supplemental data

VASCULAR BIOLOGY

Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes
Heinz Läubli,Katharina-Susanne Spanaus,Lubor Borsig
View Articletitled, Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes
Supplemental data
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis
Robert C. Doebele,Frank T. Schulze-Hoepfner,Jia Hong,Alexandre Chlenski,Benjamin D. Zeitlin,Kushboo Goel,Suzana Gomes,Yuru Liu,Mark K. Abe,Jacques E. Nor,Mark W. Lingen,Marsha Rich Rosner
View Articletitled, A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis
Supplemental data

CORRESPONDENCE

The role of cytogenetic abnormalities in acute myeloid leukemia with NPM1 mutations and no FLT3 internal tandem duplication
Jean Baptiste Micol,Nicolas Boissel,Aline Renneville,Sylvie Castaigne,Claude Gardin,Claude Preudhomme,Hervé Dombret
View Articletitled, The role of cytogenetic abnormalities in acute myeloid leukemia with <em>NPM1</em> mutations and no <em>FLT3</em> internal tandem duplication
Response: NPM1-mutated AML is an entity irrespective of whether or not chromosomal aberrations are present
Claudia Haferlach,Marco Vignetti,Torsten Haferlach,Brunangelo Falini
View Articletitled, Response: <em>NPM1</em>-mutated AML is an entity irrespective of whether or not chromosomal aberrations are present
Elevated fibrinogen γ′ ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome
Elim Y. L. Cheung,Hans L. Vos,Marieke J. H. A. Kruip,Heleen M. den Hertog,J. Wouter Jukema,Moniek P. M. de Maat
View Articletitled, Elevated fibrinogen γ′ ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome
Response: Elevated fibrinogen γ′ ratios and clinical outcomes
Ulrike Nowak-Göttl,Hartmut Weiler,Monika Stoll
View Articletitled, Response: Elevated fibrinogen γ′ ratios and clinical outcomes
Allogeneic transplantation for children and adolescents with Hodgkin lymphoma
Norbert Schmitz,Anna Sureda,Giorgio Dini,Alexander Claviez,on behalf of the Lymphoma and Pediatric Diseases Working Parties
View Articletitled, Allogeneic transplantation for children and adolescents with Hodgkin lymphoma

ERRATA

van de Vosse et al. Antisense-mediated exon skipping to correct IL-12Rβ1 deficiency in T cells. Blood. 2009;113(19):4548–4555.
View Articletitled, van de Vosse et al. Antisense-mediated exon skipping to correct IL-12Rβ1 deficiency in T cells. <em>Blood</em>. 2009;113(19):<span class="related-article">4548–4555</span>.
  • Cover Image

    Cover Image

    issue cover

    Iron chelators trap iron being released from ferritin protein nanocages in the cytoplasm or dissolved from degraded ferritin/hemosiderin in lysosomes. Ferritin protein in the cytoplasm is degraded by proteosomes while ferritin in lysosomes is degraded by lysosomal hydrolases. De Domenico et al show that the chelator desferrioxamine targets ferritin/hemosiderin iron in lysosomes, while the chelators deferriprone and desferasirox target ferritin iron in the cytoplasm. Thus, the 2 different cell compartments where ferritin iron is mined are selectively targeted by the oral or injectable iron chelators in current use. Professional illustration by A. Y. Chen. See the commentary by Theil on page 4325 and the article by De Domenico et al on p 4546.

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