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Issue Archive

Volume 114, Issue 18
October 29 2009
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Donors, donors, and more donors
Paolo Anderlini
View Articletitled, Donors, donors, and more donors
CLINICAL TRIALS
TPO-mimetics and myelofibrosis? A reticulin question!
Michele P. Lambert
View Articletitled, TPO-mimetics and myelofibrosis? A reticulin question!
IMMUNOBIOLOGY
HIV infection: TRAILing the killers
Andrea Cerutti
View Articletitled, HIV infection: TRAILing the killers
INSIDE BLOOD
Turning up the heat on myeloma
Frits van Rhee
View Articletitled, Turning up the heat on myeloma

REVIEW ARTICLES

Epigenetic mechanisms of regulation of Foxp3 expression
Girdhari Lal,Jonathan S. Bromberg
View Articletitled, Epigenetic mechanisms of regulation of Foxp3 expression

HOW I TREAT

How I treat hypereosinophilic syndromes
Amy D. Klion
View Articletitled, How I treat hypereosinophilic syndromes

CLINICAL TRIALS AND OBSERVATIONS

A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults
Clinical Trials & Observations
Pablo Bartolucci,Tony El Murr,Françoise Roudot-Thoraval,Anoosha Habibi,Aline Santin,Bertrand Renaud,Violaine Noël,Marc Michel,Dora Bachir,Frédéric Galactéros,Bertrand Godeau
View Articletitled, A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults
Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
Clinical Trials & Observations
David J. Kuter,Ghulam J. Mufti,Barbara J. Bain,Robert P. Hasserjian,Wende Davis,Mark Rutstein
View Articletitled, Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors
Clinical Trials & Observations
Kristina Hölig,Michael Kramer,Frank Kroschinsky,Martin Bornhäuser,Thilo Mengling,Alexander H. Schmidt,Claudia Rutt,Gerhard Ehninger
View Articletitled, Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors
Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol
Clinical Trials & Observations
Marieke H. van der Linden,Maria Grazia Valsecchi,Paola De Lorenzo,Anja Möricke,Gritta Janka,Thierry M. Leblanc,Maria Felice,Andrea Biondi,Myriam Campbell,Ian Hann,Jeffrey E. Rubnitz,Jan Stary,Tomasz Szczepanski,Ajay Vora,Alina Ferster,Liisa Hovi,Lewis B. Silverman,Rob Pieters
View Articletitled, Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol
Supplemental data
Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies
Brief Report
Animesh Pardanani,Ken-Hong Lim,Terra L. Lasho,Christy Finke,Rebecca F. McClure,Chin-Yang Li,Ayalew Tefferi
View Articletitled, Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies
Supplemental data

HEMATOPOIESIS AND STEM CELLS

On the adaptation of endosteal stem cell niche function in response to stress
Yi Jiang,Halvard Bonig,Tatiana Ulyanova,KaiHsin Chang,Thalia Papayannopoulou
View Articletitled, On the adaptation of endosteal stem cell niche function in response to stress
Supplemental data
Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model
Xiaoxia Hu,Hongmei Shen,Chen Tian,Hui Yu,Guoguang Zheng,Richard XuFeng,Zhenyu Ju,Jing Xu,Jianmin Wang,Tao Cheng
View Articletitled, Kinetics of normal hematopoietic stem and progenitor cells in a <em>Notch1</em>-induced leukemia model
Supplemental data

IMMUNOBIOLOGY

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
Qing Zhou,Christoph Bucher,Meghan E. Munger,Steven L. Highfill,Jakub Tolar,David H. Munn,Bruce L. Levine,Megan Riddle,Carl H. June,Daniel A. Vallera,Brenda J. Weigel,Bruce R. Blazar
View Articletitled, Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
Supplemental data
Obesity accelerates thymic aging
Hyunwon Yang,Yun-Hee Youm,Bolormaa Vandanmagsar,Jennifer Rood,K. Ganesh Kumar,Andrew A. Butler,Vishwa Deep Dixit
View Articletitled, Obesity accelerates thymic aging
Supplemental data
Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation
Florian Göbel,Sabine Taschner,Jennifer Jurkin,Sabine Konradi,Christine Vaculik,Susanne Richter,Doris Kneidinger,Christina Mühlbacher,Christian Bieglmayer,Adelheid Elbe-Bürger,Herbert Strobl
View Articletitled, Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation
Supplemental data
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer–cell subsets associated with high levels of HIV-1 viremia
Enrico Brunetta,Manuela Fogli,Stefania Varchetta,Luisa Bozzo,Kelly L. Hudspeth,Emanuela Marcenaro,Alessandro Moretta,Domenico Mavilio
View Articletitled, The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer–cell subsets associated with high levels of HIV-1 viremia
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts
Yongzhi Cui,Hua Zhang,Joanna Meadors,Rita Poon,Martin Guimond,Crystal L. Mackall
View Articletitled, Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts
Supplemental data
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface
Andrew Zloza,Jason M. Schenkel,Allan R. Tenorio,Jeffrey A. Martinson,Paul M. Jeziorczak,Lena Al-Harthi
View Articletitled, Potent HIV-specific responses are enriched in a unique subset of CD8<sup>+</sup> T cells that coexpresses CD4 on its surface
Supplemental data
Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients
Georg Stary,Irene Klein,Sabine Kohlhofer,Frieder Koszik,Thomas Scherzer,Leonhard Müllauer,Heribert Quendler,Norbert Kohrgruber,Georg Stingl
View Articletitled, Plasmacytoid dendritic cells express TRAIL and induce CD4<sup>+</sup> T-cell apoptosis in HIV-1 viremic patients
Supplemental data

LYMPHOID NEOPLASIA

CD20-targeted tetrameric interferon-α, a novel and potent immunocytokine for the therapy of B-cell lymphomas
Edmund A. Rossi,David M. Goldenberg,Thomas M. Cardillo,Rhona Stein,Chien-Hsing Chang
View Articletitled, CD20-targeted tetrameric interferon-α, a novel and potent immunocytokine for the therapy of B-cell lymphomas
Supplemental data
Karyotype-specific microRNA signature in chronic lymphocytic leukemia
Rosa Visone,Laura Z. Rassenti,Angelo Veronese,Cristian Taccioli,Stefan Costinean,Baltazar D. Aguda,Stefano Volinia,Manuela Ferracin,Jeff Palatini,Veronica Balatti,Hansjuerg Alder,Massimo Negrini,Thomas J. Kipps,Carlo M. Croce
View Articletitled, Karyotype-specific microRNA signature in chronic lymphocytic leukemia
Supplemental data
Myeloma cell line–derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma
Jianfei Qian,Sungyoul Hong,Siqing Wang,Liang Zhang,Luhong Sun,Michael Wang,Jing Yang,Larry W. Kwak,Jian Hou,Qing Yi
View Articletitled, Myeloma cell line–derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma
Supplemental data
C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells
Rekha Pal,Martin Janz,Deborah L. Galson,Margarete Gries,Shirong Li,Korinna Jöhrens,Ioannis Anagnostopoulos,Bernd Dörken,Markus Y. Mapara,Lisa Borghesi,Lela Kardava,G. David Roodman,Christine Milcarek,Suzanne Lentzsch
View Articletitled, C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells
Supplemental data

MYELOID NEOPLASIA

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
Britta Will,Masahiro Kawahara,Julia P. Luciano,Ingmar Bruns,Samir Parekh,Connie L. Erickson-Miller,Manuel A. Aivado,Amit Verma,Ulrich Steidl
View Articletitled, Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts
Rifca Le Dieu,David C. Taussig,Alan G. Ramsay,Richard Mitter,Faridah Miraki-Moud,Rewas Fatah,Abigail M. Lee,T. Andrew Lister,John G. Gribben
View Articletitled, Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
Jeffrey M. Beekman,Liesbeth P. Verhagen,Niels Geijsen,Paul J. Coffer
View Articletitled, Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume
Lionel Blanc,Jing Liu,Michel Vidal,Joel Anne Chasis,Xiuli An,Narla Mohandas
View Articletitled, The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume
Supplemental data
Amelioration of Sardinian β0 thalassemia by genetic modifiers
Brief Report
Renzo Galanello,Serena Sanna,Lucia Perseu,Maria Carla Sollaino,Stefania Satta,Maria Eliana Lai,Susanna Barella,Manuela Uda,Gianluca Usala,Goncalo R. Abecasis,Antonio Cao
View Articletitled, Amelioration of Sardinian β<sup>0</sup> thalassemia by genetic modifiers

THROMBOSIS AND HEMOSTASIS

Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity
Henriët Meems,Alexander B. Meijer,David B. Cullinan,Koen Mertens,Gary E. Gilbert
View Articletitled, Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity

TRANSPLANTATION

The human alloreactive CD4+ T-cell repertoire is biased to a Th17 response and the frequency is inversely related to the number of HLA class II mismatches
Nicolle H. R. Litjens,Jacqueline van de Wetering,Nicole M. van Besouw,Michiel G. H. Betjes
View Articletitled, The human alloreactive CD4<sup>+</sup> T-cell repertoire is biased to a Th17 response and the frequency is inversely related to the number of HLA class II mismatches
Supplemental data
Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors
Brief Report
John Koreth,Kristen E. Stevenson,Haesook T. Kim,Michael Garcia,Vincent T. Ho,Philippe Armand,Corey Cutler,Jerome Ritz,Joseph H. Antin,Robert J. Soiffer,Edwin P. Alyea, III
View Articletitled, Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors
Supplemental data

VASCULAR BIOLOGY

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib
Johann Kern,Gerold Untergasser,Christoph Zenzmaier,Bettina Sarg,Guenther Gastl,Eberhard Gunsilius,Michael Steurer
View Articletitled, GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib
Supplemental data

CORRESPONDENCE

Granzyme A is a proinflammatory protease
Julián Pardo,Markus M. Simon,Christopher J. Froelich
View Articletitled, Granzyme A is a proinflammatory protease
Response: Granzyme A: cell death–inducing protease, proinflammatory agent, or both?
Denis Martinvalet,Michael Walch,Danielle K. Jensen,Jerome Thiery,Judy Lieberman
View Articletitled, Response: Granzyme A: cell death–inducing protease, proinflammatory agent, or both?
Clonotypic B cells in classic Hodgkin lymphoma
Ralf Küppers
View Articletitled, Clonotypic B cells in classic Hodgkin lymphoma
Response: Hodgkin lymphoma stem cells
Richard J. Jones,Christopher D. Gocke,Richard F. Ambinder,William Matsui
View Articletitled, Response: Hodgkin lymphoma stem cells
Is the recommended daily iron intake for women too low?
D. Hugh Rushton,Robin Dover,Michael J. Norris,Jeremy J. H. Gilkes
View Articletitled, Is the recommended daily iron intake for women too low?

ERRATA

Tremblay et al. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008;112(5):2062–2070.
View Articletitled, Tremblay et al. HES1 is a novel interactor of the Fanconi anemia core complex. <em>Blood</em>. 2008;112(5):<span class="related-article">2062–2070</span>.
Klibi et al. Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. Blood. 2009;113(9):1957–1966.
View Articletitled, Klibi et al. Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. <em>Blood</em>. 2009;113(9):<span class="related-article">1957–1966</span>.
Schmitz et al. Response: Intrathecal methotrexate and central nervous system events. Blood. 2009;114(9):1999–2000.
View Articletitled, Schmitz et al. Response: Intrathecal methotrexate and central nervous system events. <em>Blood</em>. 2009;114(9):<span class="related-article">1999–2000</span>.
  • Cover Image

    Cover Image

    issue cover

    IL-5 selectively drives the differentiation of eosinophils from hematopoietic progenitor cells. IL-5–specific signaling pathways were explored via modulation of syntenin, an IL-5Rα–binding adapter protein, in human hematopoietic progenitor cells. Cytospins of CD34+ cells transduced with syntenin and stained by May-Grünwald-Giemsa revealed enhanced IL-5–induced eosinophil numbers as shown in this photograph. See the article by Beekman et al on page 3917.

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