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Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34+ cell dose
Issue Archive
September 24 2009
In this Issue
Table of Contents
INSIDE BLOOD
PERSPECTIVE
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
Clinical Trials & Observations
Thorsten Zenz,Sonja Häbe,Tina Denzel,Julia Mohr,Dirk Winkler,Andreas Bühler,Antonio Sarno,Silja Groner,Daniel Mertens,Raymonde Busch,Michael Hallek,Hartmut Döhner,Stephan Stilgenbauer
Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34+ cell dose
Clinical Trials & Observations
Michael A. Pulsipher,Pintip Chitphakdithai,Brent R. Logan,Susan F. Leitman,Paolo Anderlini,John P. Klein,Mary M. Horowitz,John P. Miller,Roberta J. King,Dennis L. Confer
GENE THERAPY
IMMUNOBIOLOGY
Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells
Francois Romagné,Pascale André,Pieter Spee,Stefan Zahn,Nicolas Anfossi,Laurent Gauthier,Marusca Capanni,Loredana Ruggeri,Don M. Benson, Jr,Bradley W. Blaser,Mariella Della Chiesa,Alessandro Moretta,Eric Vivier,Michael A. Caligiuri,Andrea Velardi,Nicolai Wagtmann
LYMPHOID NEOPLASIA
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Lisa J. Russell,Melania Capasso,Inga Vater,Takashi Akasaka,Olivier A. Bernard,Maria Jose Calasanz,Thiruppavaii Chandrasekaran,Elise Chapiro,Stephan Gesk,Mike Griffiths,David S. Guttery,Claudia Haferlach,Lana Harder,Olaf Heidenreich,Julie Irving,Lyndal Kearney,Florence Nguyen-Khac,Lee Machado,Lynne Minto,Aneela Majid,Anthony V. Moorman,Heather Morrison,Vikki Rand,Jonathan C. Strefford,Claire Schwab,Holger Tönnies,Martin J. S. Dyer,Reiner Siebert,Christine J. Harrison
Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progression
Jui Dutta-Simmons,Yunyu Zhang,Gullu Gorgun,Moshe Gatt,Mala Mani,Teru Hideshima,Kohichi Takada,Nicole E. Carlson,Daniel E. Carrasco,Yu-Tzu Tai,Noopur Raje,Anthony G. Letai,Kenneth C. Anderson,Daniel R. Carrasco
Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
David Dornan,Fiona Bennett,Yvonne Chen,Mark Dennis,Dan Eaton,Kristi Elkins,Dorothy French,Mary Ann T. Go,Andrew Jack,Jagath R. Junutula,Hartmut Koeppen,Jeffrey Lau,Jacqueline McBride,Andy Rawstron,Xiaoyan Shi,Nancy Yu,Shang-Fan Yu,Peng Yue,Bing Zheng,Allen Ebens,Andrew G. Polson
MYELOID NEOPLASIA
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
Warren Fiskus,Yongchao Wang,Arun Sreekumar,Kathleen M. Buckley,Huidong Shi,Anand Jillella,Celalettin Ustun,Rekha Rao,Pravina Fernandez,Jianguang Chen,Ramesh Balusu,Sanjay Koul,Peter Atadja,Victor E. Marquez,Kapil N. Bhalla
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
Tamer E. Fandy,James G. Herman,Patrick Kerns,Anchalee Jiemjit,Elizabeth A. Sugar,Si-Ho Choi,Allen S. Yang,Timothy Aucott,Tianna Dauses,Rosalie Odchimar-Reissig,Jonathan Licht,Melanie J. McConnell,Chris Nasrallah,Marianne K. H. Kim,Weijia Zhang,Yezou Sun,Anthony Murgo,Igor Espinoza-Delgado,Katharine Oteiza,Ibitayo Owoeye,Lewis R. Silverman,Steven D. Gore,Hetty E. Carraway
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry
Hemant Kulkarni,Vincent C. Marconi,Weijing He,Michael L. Landrum,Jason F. Okulicz,Judith Delmar,Dickran Kazandjian,John Castiblanco,Seema S. Ahuja,Edwina J. Wright,Robin A. Weiss,Robert A. Clark,Matthew J. Dolan,Sunil K. Ahuja
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
Stefan P. Kastl,Walter S. Speidl,Katharina M. Katsaros,Christoph Kaun,Gersina Rega,Afshin Assadian,Georg W. Hagmueller,Martina Hoeth,Rainer de Martin,Yongsheng Ma,Gerald Maurer,Kurt Huber,Johann Wojta
TRANSPLANTATION
VASCULAR BIOLOGY
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Lubka T. Roumenina,Mathieu Jablonski,Christophe Hue,Jacques Blouin,Jordan D. Dimitrov,Marie-Agnes Dragon-Durey,Mathieu Cayla,Wolf H. Fridman,Marie-Alice Macher,David Ribes,Luc Moulonguet,Lionel Rostaing,Simon C. Satchell,Peter W. Mathieson,Catherine Sautes-Fridman,Chantal Loirat,Catherine H. Regnier,Lise Halbwachs-Mecarelli,Veronique Fremeaux-Bacchi
CORRESPONDENCE
ERRATUM
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Cover Image
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It is unclear how neutrophils control Aspergillus species in healthy persons. Due to their large size, Aspergillus hyphae (red) cannot be phagocytosed by neutrophils (green). Bianchi et al show in this issue that recently discovered NADPH oxidase–dependent microbicidal pathways through neutrophil extracellular traps (NETs) are efficient against Aspergillus conidia and hyphae in vitro, and that restoration of NET formation by gene therapy of NADPH oxidase–deficient X-linked chronic granulomatous disease aided clearing severe invasive Aspergillus nidulans infection in vivo, underlining the role of functional NADPH oxidase in NET formation and antifungal activity. See the article by Bianchi et al on page 2619.
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